DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and Slco2a1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_201571.2	Gene:	Slco2a1 / 24059	MGIID:	1346021	Length:	643	Species:	Mus musculus

Alignment Length:	734	Identity:	194/734 - (26%)
Similarity:	319/734 - (43%)	Gaps:	165/734 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99
            |:|:..:|||...|.:...||..:|||:||||.:.|.::|:|.|.||||..:|.:.:||.|.:.|
Mouse    32 KVFVLCHGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVN 96

  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTERL 164
            |||.|..|.:......::|.||||:          ::.||  ..:.|.|:...||  :.:..:.|
Mouse    97 RPRMIGIGGLLLAAGAFVLTLPHFL----------SEPYQ--YASTTAGNSSHFQ--TDLCQKHL 147

  Fly   165 CG---------VDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLM 220
            .|         |..|:.:...::|     |:.::|.:.|||.......|.:|:||..:.||:||.
Mouse   148 PGLLPSKCHSTVPDTQKETSSMWS-----LMVVAQLLAGVGTVPIQPFGISYVDDFAEPTNSPLY 207

  Fly   221 LAVAMALRMIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFS 281
            :::..|:.:.||..|:..|.:.|..|:|    .|.|..:...||||:||||||.:|....:.:.|
Mouse   208 ISILFAIAVFGPAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLISSGFLIVTS 272

  Fly   282 GLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLP 346
            .....||:.:     ||......:|    :|.:|.||:.|..|      .:|.|
Mouse   273 LPFFFFPRAM-----SRGAERSVIA----EETMKMEEDKSRGS------LMDFI----------- 311

  Fly   347 KLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMG 411
              |.|||..:|||.|.|.:..:||...:....:|..|||.|::|.|:...|..|.:::|.:::..
Mouse   312 --KRFPRIFLRLLMNPLFMLVVLSQCTFSSVIAGLSTFLNKFLEKQYDASAAYANLLIGAVNLPA 374

  Fly   412 MVVGLIGSGMVLSK------KKPSVSKVLMWNVIVGGISILGQISYAFLYCPNTFSMTQAGQLNL 470
            ..:|::..|:::.:      ..|.|:..:|      .|||:......|:.| :|.::.:....:.
Mouse   375 AALGMLFGGILMKRFVFPLQTIPRVAATIM------TISIILCAPLFFMGC-STPAVAEVYPPST 432

  Fly   471 TSN-------CNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATS-----KLYEDCSCVVN 523
            .|:       |..:|.|....:.|||.: ....:.|.|||||...|.:|     .:|.:||||..
Mouse   433 PSSIHPQPPACRRDCLCPDSVFHPVCGD-NGVEYLSPCHAGCSSLNVSSAASKQPIYLNCSCVTG 496

  Fly   524 DPA-------PKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTS 581
            ..|       |.|.||.||        |.:    :...:::.:..:..|
Mouse   497 GSASAKTGSCPTSCAQLLL--------PSI----FLISFVALIACVSHN---------------- 533

  Fly   582 DSVIRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLL 646
                                .:..|::                |.|..::||||.|:..:::.||
Mouse   534 --------------------PLYMMVL----------------RVVNQDEKSFAIGVQFLLMRLL 562

  Fly   647 ALIPGPIIFGRLIDSTCLVWTKTCNG-NGNCQLYDQTRFRYSLNFLSCLLTFMG-LLFDYLVWYY 709
            |.:|.|.::|.||||:|:.|...|:| .|.|..||....|.....|..:...:| ||..::.|..
Mouse   563 AWLPSPSLYGLLIDSSCIRWNYLCSGRRGACAYYDNDALRNRYLGLQVIYKVLGTLLLFFISWRV 627

  Fly   710 GRNLDIYGDKEAKEEERAN 728
            .:|      :|...:|.|:
Mouse   628 KKN------REYSLQENAS 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	183/686 (27%)
		MFS	40..>280	CDD:119392	81/252 (32%)
		DUF4064	364..447	CDD:290013	20/88 (23%)
		KAZAL_SLC21	470..521	CDD:238650	18/62 (29%)
Slco2a1	NP_201571.2	oat	1..629	CDD:273279	190/715 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		MFS	<166..>425	CDD:119392	81/298 (27%)
		KAZAL_SLC21	441..494	CDD:238650	17/53 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835537
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750