DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Ea and F47E1.4

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_509532.1	Gene:	F47E1.4 / 181146	WormBaseID:	WBGene00018568	Length:	728	Species:	Caenorhabditis elegans

Alignment Length:	817	Identity:	191/817 - (23%)
Similarity:	316/817 - (38%)	Gaps:	215/817 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRNR 100
            :|:.::.::..::::...|....|.::|::|::.|..:|:::|..|...|...:|:||.|.:.||
Worm     6 IFIVLFVVVFFLESIGASYIYTALQSIERQFQMSSGISGLLVSATECGYIPCVVIMSYFGSKGNR 70

  Fly   101 PRWIAWGIVFCGLSCYILVLPHFIYGAGHE----------------------------------- 130
            .|||..|::...::..:|..|:|::....:
Worm    71 SRWIGGGVLLMSITYLMLGTPNFLFPTRQQKTNGLNISESLRPTPSQLLPNSTLKDLLSYPLMED 135

  Fly   131 ---------VLQFTKE------------YQDSLLNGTTG---------------------SDHSF 153
                     :|..|.:            .|.|..|.|.|                     |.:|.
Worm   136 QLPSSTYQFLLNLTDDKTPIEQTQTEPTEQGSNPNVTFGIDGYLMKGILIEADNLVKNNYSQNSI 200

  Fly   154 QNISSVKTERLCGVDKTEDD--------------CDDLFSYV-----------------PLVLIF 187
            :.:.|:...|  .|:::.||              |..|.:::                 |.::.|
Worm   201 KQLLSMFIHR--RVNRSIDDIQKMKTKAVVPFTVCGKLTNFLRASIENSKCRAGSSNIWPFLVFF 263

  Fly   188 LSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKT 252
            :|.|.||||.|:.::||...||||.||.:.|:......::|::||:.|:..|..| |.|....:.
Worm   264 VSLFFLGVGRTIPWNLGIPLLDDNIKKKHLPMYFGAIASIRVLGPICGYLIGSFS-NQFYYTLQA 327

  Fly   253 PL-IDSKDPRWLGAWWLGWVILGTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKR 316
            |. :...:..|:||||||::::|.|....|.|:..||:        ..||.|.|      .|::.
Worm   328 PSGLTPVNQGWIGAWWLGFLLIGALSMFPSLLLFFFPQ--------GKNSTLQL------REIRE 378

  Fly   317 EENLSLSSRFSSNAALDTIGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGF 381
            .:|                |.|:.:.....|:|:|..:...:|..|:....:|..|..|....|:
Worm   379 NKN----------------GRASESKPIKMKIKEFVISCKSVLGTKIFTGCLLGRVCDIFAFKGY 427

  Fly   382 MTFLTKYMEVQFHKDAQSATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISIL 446
            :.||.||:|.||..........:....:.|..:|:...|.:..|.:.:..:..:..:||..::|.
Worm   428 VVFLPKYLETQFGIPQYLVHRYMSMFGVFGFGLGIALGGFITKKFRLTGRQTALLMMIVSVLNIT 492

  Fly   447 GQISYAFLYC---PNTFSM-TQAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRG 507
            ...|..|:.|   .|:..: ::....|.|:.||..||||.....||| ....|.:||.||||||
Worm   493 VYSSKIFIGCNLIVNSIGLNSRELNYNFTNECNSQCSCENAHLYPVC-SADGTAYFSPCHAGCR- 555

  Fly   508 YNATS------KLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNG 566
             .||.      ..:..|.||
Worm   556 -EATQFGSDPVIGFASCECV--------------------------------------------- 574

  Fly   567 DFDDQLLSRTRRSTSDSVIRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHED 631
                          ...|:....|...|.:|...|..|.::.|:......|.::|:..|:|....
Worm   575 --------------ESGVVSKSFCQNKCQFSSILFLATVLLGSFVAGVAVVPDMLILLRSVDVGS 625

  Fly   632 KSFAQGLALMMISLLALIPGPIIFGRLIDSTCLVWTKTCNG-NGNCQLYDQTRFRYSLNFLSCLL 695
            :|.:.||..|.|||...:|..||:|.:||:.|.||.||||| ||:|.:||....|..::.|...:
Worm   626 RSLSMGLQGMAISLFGTLPSSIIWGLVIDTACRVWDKTCNGANGSCSIYDSDHLRIWMHLLYVGV 690

  Fly   696 TFMGLLFDYLVWYYGRNLDIYGDKEAKEEERANRKDQ 732
            .|:.||.|..||....||.|..|..|...|..:..|:
Worm   691 RFISLLSDIYVWKNAGNLKIMDDPVADNIEALSNPDK 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	176/767 (23%)
		MFS	40..>280	CDD:119392	74/348 (21%)
		DUF4064	364..447	CDD:290013	18/82 (22%)
		KAZAL_SLC21	470..521	CDD:238650	22/56 (39%)
F47E1.4	NP_509532.1	oat	95..707	CDD:273279	161/706 (23%)
F47E1.4	NP_509532.1	KAZAL_SLC21	520..575	CDD:238650	24/116 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158587
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28658
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.720