DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and F47E1.2

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_509531.1	Gene:	F47E1.2 / 181145	WormBaseID:	WBGene00018566	Length:	744	Species:	Caenorhabditis elegans

Alignment Length:	827	Identity:	185/827 - (22%)
Similarity:	329/827 - (39%)	Gaps:	216/827 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRNR 100
            :|:|::..:..::|:...|....:..:|::|::.|:|:|.::|.::...|...:.:::.|.:.||
Worm     6 IFLGLFSFVFFLEAIGGSYINSAVQNIERQFQMSSRTSGFMISASDFGYIPCVVFIAHFGSKGNR 70

  Fly   101 PRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFT------------------------------ 135
            .|||..|.:...::..:|..|:|::..||..:..|
Worm    71 ARWIGAGAILVSITYLMLASPNFLFPQGHHDINTTEVSAKLKPTAGQLASNSTLKQLLSYQLIRD 135

  Fly   136 --------------------KEYQ--------------------------------DSLLNGTTG 148
                                :|||                                ::|:...|.
Worm   136 RMPHDTYMSLINLEDDTTPIEEYQPIGRPPKIGQGQSGNSTYTIDGWLFNEALVAAENLIANNTS 200

  Fly   149 SD----------HSFQNISSVKTERL----------CG--------VDKTEDDCDDLFSYVPLVL 185
            .:          |...|.|:...:::          ||        |.|.....:...:..|.::
Worm   201 QNTLRSSLSLFIHRRTNTSTKDIQKIRISAAAPFTFCGKLTNSLRAVIKDSKCKEQTSNSYPFLV 265

  Fly   186 IFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTF---I 247
            .|.|..:||:|.|:.:|||...||||.||.:.|.......::|::||:.|:..|.. .|.|   :
Worm   266 FFFSLLLLGIGRTVPWSLGVPLLDDNIKKKSLPAYFGAISSIRVLGPICGYMIGSF-CNKFYYTL 329

  Fly   248 DPTK--TPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQT 310
            :|..  ||    .||.|:||||:|::.:|::....|.::..||:       .:......:.||..
Worm   330 NPPNGLTP----ADPTWIGAWWMGFLFIGSIALFPSTMLFFFPQ-------GKEGDGSAVQLRDV 383

  Fly   311 -KEELKR--EENLSLSSRFSSNAALDTIGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAV 372
             ||:||:  :|:.:::.                      |||||.::..::|..|:.:.::|..|
Worm   384 HKEKLKKSVDEDRTITM----------------------KLKDFAKSCKKVLSTKIYMGSVLGRV 426

  Fly   373 FYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWN 437
            ..:|...|::.||.||:|..|..........:....:.|..:|:...|.|..|.|.:..:..|:.
Worm   427 CDVLAFKGYIVFLPKYLENHFGIPQYLVHRYMAMFGVFGFGLGVATGGYVTKKLKLNGRRAAMFV 491

  Fly   438 VIVGGISILGQISYAFLYCPNTF----SMTQAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFF 498
            :::..:::.......|:.|.:..    |..:....|.|..||..||||.....||| :.|...:|
Worm   492 MLMSTLNVCLYSGKIFIGCESIVNSIGSNNRQTNYNFTRECNSQCSCENARLYPVC-DQTGFAYF 555

  Fly   499 SACHAGCRGYNATSKLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLD 563
            |.||||||                             ..:|...:|.||.|:.
Worm   556 SPCHAGCR-----------------------------EAMQYGSDPVLDFTSC------------ 579

  Fly   564 DNGDFDDQLLSRTRRSTSDSVIRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVA 628
                          :.....|:....|...|..|...|.:|.:..|:....|.|..:|:..|:|.
Worm   580 --------------QCAPGGVVSKKFCENTCKTSSVIFFLTVLPGSFVAGLGVVPAMLILLRSVP 630

  Fly   629 HEDKSFAQGLALMMISLLALIPGPIIFGRLIDSTCLVWTKTCNG-NGNCQLYDQTRFRYSLNFLS 692
            .|.:|.:.||..|.:||...:|.||::|.:||:.||||.|.||| .|:|.:|...|.|..::.|.
Worm   631 PETRSLSLGLQGMAVSLFGTLPSPILWGLVIDAACLVWDKACNGARGSCSIYHPDRLRVWMHLLY 695

  Fly   693 CLLTFMGLLFDYLVWYYGRNLDIYGDKEAKEEERANR---KDQPITP 736
            .::..:.|:.|..||.:.:||:|..:..::|::...|   |.|.:.|
Worm   696 VVIRTVALITDVYVWKHAKNLNIMDEPVSEEKDNIRRNSIKMQAVQP 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	170/770 (22%)
		MFS	40..>280	CDD:119392	70/354 (20%)
		DUF4064	364..447	CDD:290013	17/82 (21%)
		KAZAL_SLC21	470..521	CDD:238650	19/50 (38%)
F47E1.2	NP_509531.1	MFS	8..>92	CDD:119392	18/83 (22%)
		oat	95..715	CDD:273279	156/709 (22%)
		MFS	<274..>503	CDD:304372	66/262 (25%)
		KAZAL_SLC21	528..583	CDD:238650	24/110 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158588
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750