DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Ea and Y32F6B.1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_505689.2	Gene:	Y32F6B.1 / 179463	WormBaseID:	WBGene00012531	Length:	760	Species:	Caenorhabditis elegans

Alignment Length:	820	Identity:	199/820 - (24%)
Similarity:	326/820 - (39%)	Gaps:	218/820 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 FMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRNRP 101
            |..|:|.:..::::...|....:..:||:|:|||:.:|.::|..:.:.|.:.:..||.||:.||.
Worm     9 FFIVFGTVYFLESIGGFYMTSAVVFIEKQFQIPSRLSGTMVSAGDFAYIPVVIFTSYFGGKGNRA 73

  Fly   102 RWIAWGIVFCGLSCYILVLPHFIYG------AGHEVLQFTKEYQDSLLNGTTGS----------- 149
            |||..|.:...::.:::...:|::.      ..|.......:....::||...|
Worm    74 RWIGAGCILIAIANFMIASSNFLFPVEQANVTTHIPSALAHQIDRDIVNGDVNSTEHLWLEQIHP 138

  Fly   150 --DHSFQNISSV----KTERL------CGVDKTEDDCDDLFSYV--------------------- 181
              |...|.:.:.    |::.|      |...|..:.|.:|..|:
Worm   139 LIDPKNQVVMNYEGDEKSDLLQKYVEYCHYHKGSEICKNLEKYIAEKFPITDAKMSNVRAMVALP 203

  Fly   182 --------------------------PLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLM 220
                                      |.::||....|||||.|:.:|||...:|||.||.|.||.
Worm   204 YGFCHSMLNFVRAQHYACKKDQSTLGPFMMIFGGLLVLGVGRTMPFSLGLPLMDDNVKKQNLPLY 268

  Fly   221 LAVAMALRMIGPVVGFFFGFISLNTFID--PTK--TPLIDSKDPRWLGAWWLGWVILGTLMCLFS 281
            .:....::::|||:|...|......::|  |.:  |||    ||.|:|.||||::|.|||:...|
Worm   269 FSFMFFVKILGPVIGLLVGGQLNKLYVDFNPPQGLTPL----DPMWIGCWWLGFLIFGTLLFGPS 329

  Fly   282 GLIGLFPKQLPKVNASRTNSHLPLALRQTKEE------LKREENLSLSSRFSSNAALDTIGAAAG 340
            .::..||.....:||              .||      :|..:.|:|..|   :...|..|.|..
Worm   330 LVLYFFPSDDLDINA--------------PEEFDDDGKVKPRKRLNLVDR---HIKKDEQGNALM 377

  Fly   341 ANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVG 405
            ....:.|:.||...:..|::||:.:..:...:..:|...|:..|..||:|:||..........:.
Worm   378 PETIMDKINDFKATIANLVKNKIFVGAMFGRIIDVLAFKGYFVFQAKYLELQFGVPQYRIQRYIA 442

  Fly   406 PISIMGMVVGLIGSGMVLSKKKPSVSKVLMW--------------NVIVGGISILGQISYAFLYC 456
            ...|:|...|:|...:.:...|....|...|              |..||..|::|||
Worm   443 STGIVGFACGVILGSLSMKFLKLQGRKAAAWVAVCSLVAALISFANGTVGCKSVIGQI------- 500

  Fly   457 PNTFSMTQAGQLNLT----SNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGC----RGYN---- 509
                    ..|:.:.    ..|..:|.||.....||| :.:.:.::|.|||||    :.|:
Worm   501 --------GDQIKINGPVFDGCRDDCMCEQTPLYPVC-DVSGSAYYSPCHAGCAMGWKNYSIFDN 556

  Fly   510 --AT--SKLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDD 570
              ||  :.::|:|:||.|..
Worm   557 TKATVDTLIFENCACVDNKV--------------------------------------------- 576

  Fly   571 QLLSRTRRSTSDSVIRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFA 635
                   :..|.|..|    |:.|...|..|.:.....:.||..|.|..:|:..|||..|.:|.:
Worm   577 -------KEVSRSYCR----TEECEERFGRFFMHQAFGAVFGGLGVVPGMLIVLRAVPPEHRSVS 630

  Fly   636 QGLALMMISLLALIPGPIIFGRLIDSTCLVWTKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGL 700
            .|....::||||.:|.|||:|::||.:||:|.|:|:.:|:|.:||....|..|:.:...|....|
Worm   631 LGFNGFLVSLLATLPSPIIWGKIIDMSCLLWKKSCDSSGSCSVYDTDELRVRLHVIYGCLRIFSL 695

  Fly   701 LFDYLVWYYGRNLDIY-----GDKEAKEEE----RANRKD 731
            :.|..|||:.|.|.:.     .||:.||||    .:.||:
Worm   696 ISDVWVWYWARGLKLIEEETPEDKDKKEEETEKLHSKRKE 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	181/762 (24%)
		MFS	40..>280	CDD:119392	78/319 (24%)
		DUF4064	364..447	CDD:290013	19/96 (20%)
		KAZAL_SLC21	470..521	CDD:238650	18/66 (27%)
Y32F6B.1	NP_505689.2	oat	4..706	CDD:273279	189/789 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158586
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28658
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4773
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3798
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.720