DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and Slco6b1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_596903.1	Gene:	Slco6b1 / 170925	RGDID:	620278	Length:	748	Species:	Rattus norvegicus

Alignment Length:	744	Identity:	169/744 - (22%)
Similarity:	281/744 - (37%)	Gaps:	163/744 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GMANWHPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEIS 83
            |:.:...|.||::.....|:..:.:|...|.:.:....:::...|:.|.:......::.:..::|
  Rat   127 GLGSLVVPSLQRFNNINFFLISFCILTLAQGIVFGLTDLSIGNFERDFYLSHPEKILLTTAYDLS 191

  Fly    84 QIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTG 148
            .:::.:|:::.||:..|.||:|......||...|..||:..|...|.|
  Rat   192 SLLVVIIVAHYGGRGRRSRWVATAAFLVGLGSIIGALPYLKYEVIHPV----------------- 239

  Fly   149 SDHSFQNISSVKTERLCGVD--KTEDDCDDLFSYVPLVLIFLS---QFVLGVGNTLYYSLGQTYL 208
                      .:|..||..:  :|..:|:.:..: ...:|:||   |...|..:...|.||.||:
  Rat   240 ----------EETGELCKDEEQRTMPNCEKIIPF-KSEIIYLSVIGQCFQGFASMPMYVLGMTYI 293

  Fly   209 DDNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTPLIDSKDPRWLGAWWLG---- 269
            .||.......:.|.:|.|..::|..:|:..|..:|...::.:....::.....|...|:||
  Rat   294 YDNISSYLAGIYLGIADASFVLGYGLGYAVGSPNLRPSLNHSSEEKVNDNFLWWQFNWFLGFFSA 358

  Fly   270 ----WVILGTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEE----LKREENLSLSSRF 326
                |..:..|:|        ||.:||..|          .||..||.    .|:.::|.....|
  Rat   359 TLLAWFTVFPLLC--------FPHRLPGSN----------KLRVWKENEPFFYKKYKDLKYGYSF 405

  Fly   327 SSNAALDTIGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEV 391
                                  :|..|||..|::|.||:...:......|...|...||.||:|.
  Rat   406 ----------------------QDLLRALWYLVKNPLLMCYSMCKATESLALIGATEFLPKYLEN 448

  Fly   392 QFHKDAQSATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYC 456
            ||.....||.::.|.|.|.|..:|....|.::||.|.|....:.:..:...||:|..:..||:.|
  Rat   449 QFLLSPSSAALLTGIILIPGGAIGNFLGGFIVSKMKMSCKTQMRFITVTSVISLLLFVLNAFVKC 513

  Fly   457 PN------TFSMTQAGQL-NLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGC---RGYNAT 511
            ..      ......:|.| |||:.||.:|.|...:|..:|.. .:..:||.|.|||   :..|..
  Rat   514 ERVKFAGINSDYEGSGTLGNLTAPCNAHCGCTSHTYYAICGR-DEIEYFSPCFAGCLNSKELNYE 577

  Fly   512 SKLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRT 576
            ..|| :|||:.:                                  |:...|...|..|..|
  Rat   578 KTLY-NCSCIKH----------------------------------GLANADSENDPIDAFL--- 604

  Fly   577 RRSTSDSVIRPGICTKNCNW--SFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLA 639
                       |.|...|..  .|:||..:|::   |.||..:...|:..|.:.....|....:.
  Rat   605 -----------GKCNTKCYALPLFFAFFFSSIV---FSSSASIPITLIILRTLPTSLHSLGLAVT 655

  Fly   640 LMMISLLALIPGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFR-------YSLNFLSCLLT 696
            ..::.:...||||::|.....|:|..| ...|...|:|.:|::.:..       .|...:|.||:
  Rat   656 YTILRIFGSIPGPLLFRIASSSSCSYWDINKCGLRGHCWIYNKFKMMSILMGLCISCKLISTLLS 720

  Fly   697 FMGLLFDYLVWYYGRNLDIYGDKEAKEEE 725
            .:.|| .|.|...|..    |.|:.||.:
  Rat   721 LLALL-KYNVLRVGSE----GVKKTKESK 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	152/677 (22%)
		MFS	40..>280	CDD:119392	51/252 (20%)
		DUF4064	364..447	CDD:290013	24/82 (29%)
		KAZAL_SLC21	470..521	CDD:238650	19/53 (36%)
Slco6b1	NP_596903.1	OATP	144..701	CDD:281175	152/677 (22%)
		MFS	146..>510	CDD:119392	95/431 (22%)
		KAZAL_SLC21	534..587	CDD:238650	20/54 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810