Protein Alignment Oatp33Ea and Slco1a4

DIOPT Version :9

• Sequence 1: NP_001260417.1
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: NP_571981.1
• Gene: Slco1a4 / 170698
• RGDID: 621389
• Length: 661
• Species: Rattus norvegicus
• Alignment Length: 743
• Identity: 182/743 - (24%)
• Similarity: 295/743 - (39%)
• Gaps: 139/743 - (18%)

  Fly    31 YATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIG 95
            :|..|||:.........:::|..|....||.:|::|.||:...|:|....||..::|.:.:||.|
  Rat    16 FAKIKMFLLALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSIVGLINGSFEIGNLLLIIFVSYFG 80

  Fly    96 GQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSF--QNISS 158
            .:.:||..|..|....||.|:::.||||:.|      |:  ||:..|......|:..|  :|.|.
  Rat    81 TKLHRPIMIGVGCAVMGLGCFLISLPHFLMG------QY--EYETILPTSNVSSNSFFCVENRSQ 137

  Fly   159 VKTERLCGVDKTED--DCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLML 221
            .       ::.|:|  :|......:..:.:.:...:.|:|.|....||.:|::|..|..|:||.:
  Rat   138 T-------LNPTQDPSECVKEMKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYI 195

  Fly   222 AVAMALRMIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSG 282
            .:......|||::|........|.::|    .|....|...|.||:||||:|:::...:..|.|.
  Rat   196 GILETGMTIGPLIGLLLASSCANIYVDIESVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSF 260

  Fly   283 LIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPK 347
            ....|||.|||............|..:...:..:||...::
  Rat   261 PFFFFPKTLPKEGLQENVDGTENAKEKKHRKKAKEEKRGIT------------------------ 301

  Fly   348 LKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGM 412
             |||...:..|..|.:.:..||.:|..........||:.||:|.|:.|.......::|...:..:
  Rat   302 -KDFFVFMKSLSCNPIYMLFILISVLQFNAFINSFTFMPKYLEQQYGKSTAEVVFLMGLYMLPPI 365

  Fly   413 VVGLIGSGMVLSKKKPSVSK---VLMWNVIVGGISILGQISYAFLYCPNTFSMTQAG-------- 466
            .:|.:..|:::.|.|.:|.|   :..|..:  ...:|..:||. :.|.|   ...||
  Rat   366 CLGYLIGGLIMKKFKVTVKKAAHLAFWLCL--SEYLLSFLSYV-MTCDN---FPVAGLTTSYEGV 424

  Fly   467 --QL----NLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGY--NATSKLYEDCSCVVN 523
              ||    .:.::||..|:|...::.|||.: ....:.|||.|||...  ..|:.::::|||:
  Rat   425 QHQLYVENKVLADCNTRCNCSTNTWDPVCGD-NGLAYMSACLAGCEKSVGTGTNMVFQNCSCI-- 486

  Fly   524 DPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPG 588
                                                                  :|:.:|....|
  Rat   487 ------------------------------------------------------QSSGNSSAVLG 497

  Fly   589 ICTK--NCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPG 651
            :|.|  :|......|.|.::...:..|...:...:|..|.:..|:||...||....|.:||.||.
  Rat   498 LCNKGPDCANKLQYFLIIAIFGCFIYSLAGIPGYMVLLRCIKSEEKSLGVGLHAFCIRILAGIPA 562

  Fly   652 PIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGRNLDI 715
            ||.||.|||.|||.| |..|...|.|::||...||.....|...|.....:..:.:....|....
  Rat   563 PIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRLYLGLPAALRGASFVPAFFILRLTRTFQF 627

  Fly   716 YGDKEAKEEERANRKDQPITPLLAKKSE 743
            .||.|:.:.:.|..|      |..|:||
  Rat   628 PGDIESSKTDHAEMK------LTLKESE 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	166/677 (25%)
		MFS	40..>280	CDD:119392	66/247 (27%)
		DUF4064	364..447	CDD:290013	18/85 (21%)
		KAZAL_SLC21	470..521	CDD:238650	16/52 (31%)
Slco1a4	NP_571981.1	oat	1..623	CDD:273279	172/709 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820