DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Ea and Slco2b1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_006229783.1	Gene:	Slco2b1 / 140860	RGDID:	621391	Length:	693	Species:	Rattus norvegicus

Alignment Length:	722	Identity:	185/722 - (25%)
Similarity:	309/722 - (42%)	Gaps:	163/722 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIG 95
            :...|.|:..:.:|...|.|...|...:::|:||||.:.|||:|::.:.||:..|.|.|.:||.|
  Rat    47 FQNIKFFVLCHSILQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLAAFNEVGNISLILFVSYFG 111

  Fly    96 GQRNRPRWIAWGIVFCGLSCYILVLPHFI---YGAGHEVLQ-FTKEYQDSLLNGTTGSDHSFQNI 156
            .:.:|||.|..|.:...::..::.|||||   |...|...: .:::::.||...||.:..|..:.
  Rat   112 SRVHRPRMIGCGAILVAVAGLLMALPHFISEPYRYDHSSPEDRSQDFEASLCLPTTMAPASALSN 176

  Fly   157 SSVKTERLCGVDKTEDDCDDLFSYVPLV-LIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLM 220
            .|..:       :||.      .::.:| ::|.:|.:||:|.......|.:|:||....:|:||.
  Rat   177 DSCSS-------RTET------KHLTMVGIMFTAQTLLGIGGVPIQPFGISYIDDFAHHSNSPLY 228

  Fly   221 LAVAMALRMIGPVVGFFFGFISLNTFIDPTKTP----LIDSKDPRWLGAWWLGWVILGTLMCLFS 281
            |.:..|:.|:||.:.:..|.:.|..::|..:.|    .:.:|||||:||||||::|...|:.|.:
  Rat   229 LGILFAITMMGPGLAYGLGSLMLRLYVDIDRMPEGGINLTTKDPRWVGAWWLGFLISAGLVVLAA 293

  Fly   282 GLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGA----- 341
            .....||:::||                .|.||...:.:     .:..|::.:.|....:
  Rat   294 SPYFFFPREMPK----------------EKYELHFRQKV-----LAGGASIGSKGEELSSQHEPL 337

  Fly   342 --NADLPK----------LKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFH 394
              .|.||:          :|.|||.|:|.||:.:.:..:||.|......:|..|||.|::|.||.
  Rat   338 KKQAGLPQIAPDLTVVQFIKVFPRVLLRTLRHPIFLLVVLSQVCTSSMVAGTATFLPKFLERQFS 402

  Fly   395 KDAQSATIIVG----PISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLY 455
            ..|..|.:::|    |::|:|:|||    |::       |.::.:..:....:.:||.:....|.
  Rat   403 ITASFANLLLGCLTIPLAIVGIVVG----GVL-------VKRLHLSPMQCSALCLLGSLLCLLLS 456

  Fly   456 CPNTF---------SMT-----QAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCR 506
            .|..|         .:|     |.|. :|...|:..|||:...:.|||.......:.:.|||||.
  Rat   457 LPLFFIGCSTHHIAGITQDLGAQPGP-SLFPGCSEPCSCQSDDFNPVCDTSAYVEYTTPCHAGCT 520

  Fly   507 G------YNATSKLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDN 565
            |      .:.:...|.:||||..                                         |
  Rat   521 GRVVQEALDKSQVFYTNCSCVAG-----------------------------------------N 544

  Fly   566 GDFDDQLLSRTRRSTSDSVIRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHE 630
            |                 .|..|.|...|:.....|.:...:.:...|.....:.::..|.|..|
  Rat   545 G-----------------TISAGSCESACSRLVLPFILLISLGAAVASITHTPSFMLILRGVKKE 592

  Fly   631 DKSFAQGLALMMISLLALIPGPIIFGRLIDSTCLVWTKTCNGNGNCQLYDQTRFRYSLNFLSCLL 695
            ||:.|.|:..|::.:||.:|.|:|.|..||:||:.|..||.....|:.||....|.
  Rat   593 DKTLAVGMQFMLLRVLAWMPSPVIHGSAIDTTCVHWALTCGRRAVCRYYDHDLLRN--------- 648

  Fly   696 TFMGLLF 702
            .|:||.|
  Rat   649 RFIGLQF 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	179/697 (26%)
		MFS	40..>280	CDD:119392	76/248 (31%)
		DUF4064	364..447	CDD:290013	22/86 (26%)
		KAZAL_SLC21	470..521	CDD:238650	17/56 (30%)
Slco2b1	XP_006229783.1	OATP	52..646	CDD:281175	179/697 (26%)
		MFS	58..>301	CDD:119392	78/255 (31%)
		KAZAL_SLC21	484..541	CDD:238650	17/56 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339161
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750