DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and SLCO6A1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001275931.1	Gene:	SLCO6A1 / 133482	HGNCID:	23613	Length:	719	Species:	Homo sapiens

Alignment Length:	752	Identity:	178/752 - (23%)
Similarity:	296/752 - (39%)	Gaps:	180/752 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99
            :.||..|.:|...|.:.:....|::...:|.:::.:.....:....:||..::::.:::.|.::.
Human   106 RCFMIFYCILLICQGVVFGLIDVSIGDFQKEYQLKTIEKLALEKSYDISSGLVAIFIAFYGDRKK 170

  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTERL 164
                :.|           .|...|:.|.|            |||       .:|.:|:....:..
Human   171 ----VIW-----------FVASSFLIGLG------------SLL-------CAFPSINEENKQSK 201

  Fly   165 CGVDKTEDDCDDL------------FSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNT 217
            .|:   ||.|:::            |....|....|.|.|.|:.....|.||.|::|:|....:.
Human   202 VGI---EDICEEIKVVSGCQSSGISFQSKYLSFFILGQTVQGIAGMPLYILGITFIDENVATHSA 263

  Fly   218 PLMLAVAMALRMIGPVVGFFFGF----ISLNTFIDPTKTPLIDSKDPRWLGAWWL--------GW 270
            .:.|.:|....|||..:|:..|.    :..|| ...|.| .:::..|.||..||:        .|
Human   264 GIYLGIAECTSMIGYALGYVLGAPLVKVPENT-TSATNT-TVNNGSPEWLWTWWINFLFAAVVAW 326

  Fly   271 VILGTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTI 335
            ..|..|.|        ||..:|  .::|..:.            ||::.....||...
Human   327 CTLIPLSC--------FPNNMP--GSTRIKAR------------KRKQLHFFDSRLKD------- 362

  Fly   336 GAAAGANADLPKLKDFPRALMRLLRNKLLIFNILS-AVFY--ILGASGFMTFLTKYMEVQFHKDA 397
             ...|.|     :||...||..|::|.:||...|| |..|  |:|||   .||..|:|.||....
Human   363 -LKLGTN-----IKDLCAALWILMKNPVLICLALSKATEYLVIIGAS---EFLPIYLENQFILTP 418

  Fly   398 QSATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYC-PNTFS 461
            ..||.:.|.:.|.|..:|.:..|:::|..:.|...::.:.::...||::..:...|:.| |..|:
Human   419 TVATTLAGLVLIPGGALGQLLGGVIVSTLEMSCKALMRFIMVTSVISLILLVFIIFVRCNPVQFA 483

  Fly   462 -----MTQAGQL-NLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATS--KLYEDC 518
                 ....|:| |||:.||..|.|....|:.:|.. .|..:||.|.|||....|.:  |:|.:|
Human   484 GINEDYDGTGKLGNLTAPCNEKCRCSSSIYSSICGR-DDIEYFSPCFAGCTYSKAQNQKKMYYNC 547

  Fly   519 SCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDS 583
            ||:                                  ..|:...|..|||.|
Human   548 SCI----------------------------------KEGLITADAEGDFID------------- 565

  Fly   584 VIRPGICTKNCNW--SFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLL 646
             .|||.|...|..  .|.||..:::|.|  |.|| |..||...|.|..:.:|.|.|::.:::.:.
Human   566 -ARPGKCDAKCYKLPLFIAFIFSTLIFS--GFSG-VPIVLAMTRVVPDKLRSLALGVSYVILRIF 626

  Fly   647 ALIPGPIIFGRLIDSTCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWY-Y 709
            ..||||.||....:::|::. ...|...|.|.:|::|:..:.|..:..|.....::|..:.:: |
Human   627 GTIPGPSIFKMSGETSCILRDVNKCGHTGRCWIYNKTKMAFLLVGICFLCKLCTIIFTTIAFFIY 691

  Fly   710 GRNLDIYGDKEAKEEERANRKDQPI-TPLLAKKSEQE 745
            .|.|:          |..:..|..: .|.:.||.|.:
Human   692 KRRLN----------ENTDFPDVTVKNPKVKKKEETD 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	166/686 (24%)
		MFS	40..>280	CDD:119392	54/263 (21%)
		DUF4064	364..447	CDD:290013	27/85 (32%)
		KAZAL_SLC21	470..521	CDD:238650	20/52 (38%)
SLCO6A1	NP_001275931.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		OATP	107..665	CDD:281175	166/686 (24%)
		MFS	109..>330	CDD:119392	52/259 (20%)
		KAZAL_SLC21	498..551	CDD:238650	21/87 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810