DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and SLCO2B1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_016872646.1	Gene:	SLCO2B1 / 11309	HGNCID:	10962	Length:	711	Species:	Homo sapiens

Alignment Length:	735	Identity:	196/735 - (26%)
Similarity:	313/735 - (42%)	Gaps:	143/735 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99
            |:|:..:.||...|.|...|...:::|:||||.:.|||:|::.|.||:....|.:.:||.|.:.:
Human    51 KLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVH 115

  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQF--------TKEYQDSLLNGTT---GSDHSF 153
            |||.|.:|.:...|:..::.|||||    .|..::        .::::.||...||   .|..|.
Human   116 RPRMIGYGAILVALAGLLMTLPHFI----SEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSN 176

  Fly   154 QNISS-VKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNT 217
            .|.|| .:|:.|..|.                ::|::|.:||||.......|.:|:||....:|:
Human   177 GNCSSYTETQHLSVVG----------------IMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNS 225

  Fly   218 PLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTP----LIDSKDPRWLGAWWLGWVILGTLMC 278
            ||.|.:..|:.|:||.:.|..|.:.|..::|..:.|    .:..|||||:||||||::|....:.
Human   226 PLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVA 290

  Fly   279 LFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANA 343
            |.:.....|||::||...........||:..:... |.:::.|..|...|....|.:...|....
Human   291 LAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPAR-KGKDSPSKQSPGESTKKQDGLVQIAPNLT 354

  Fly   344 DLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPIS 408
            .:..:|.|||.|::.||:.:.:..:||.|.....|:|..|||.|::|.||...|..|.:::|.:|
Human   355 VIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLS 419

  Fly   409 IMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPNTFSMTQAGQ------ 467
            ...::||::..|::       |.::.:..|..|.:.:||.:...|...|..|....:.|
Human   420 FPSVIVGIVVGGVL-------VKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITH 477

  Fly   468 -------LNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSKL------YEDCS 519
                   |.|:.:|...|||....:.|||...|...:.:.|||||..:.....|      |.:||
Human   478 QTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCS 542

  Fly   520 CVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSV 584
            |||                                  .|.|:|
Human   543 CVV----------------------------------EGNPVL---------------------- 551

  Fly   585 IRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALI 649
              .|.|...|:.....|.:...:.|.........:.::..|.|..|||:.|.|:..|.:.:||.:
Human   552 --AGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWM 614

  Fly   650 PGPIIFGRLIDSTCLVWTKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDY---------L 705
            |.|:|.|..||:||:.|..:|.....|:.|:....|.         .|:||.|.:         |
Human   615 PSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRN---------RFIGLQFFFKTGSVICFAL 670

  Fly   706 VWYYGRNLDIYGDKEAKEEE 725
            |....|.    .||||:.:|
Human   671 VLAVLRQ----QDKEARTKE 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	182/682 (27%)
		MFS	40..>280	CDD:119392	80/255 (31%)
		DUF4064	364..447	CDD:290013	22/82 (27%)
		KAZAL_SLC21	470..521	CDD:238650	18/56 (32%)
SLCO2B1	XP_016872646.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145470
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750