DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp33Ea and Slco3a1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_076397.2	Gene:	Slco3a1 / 108116	MGIID:	1351867	Length:	710	Species:	Mus musculus

Alignment Length:	688	Identity:	188/688 - (27%)
Similarity:	294/688 - (42%)	Gaps:	130/688 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRNRPRWIAWGIV 109
            ||:.|    |.:..|||||:||.:.|...|:|.|..||..:.|.|.:||.|.:.:|||.|..|.:
Mouse    54 GTVGA----YLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGI 114

  Fly   110 FCGLSCYILVLPHFI-----YGAGHEVLQFTKEYQDSLLNGTTGSDHSFQNISSVKTERLCGVDK 169
            ...|...:..||.|:     |.||.  :::..|.:|......:.||.              |.|
Mouse   115 VMALGALLSALPEFLTHQYKYEAGE--IRWGAEGRDVCATNGSSSDE--------------GPD- 162

  Fly   170 TEDDCDDLF------SYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMALR 228
                 .||.      :.:..:|:..:|.:||:|.|....||.:|:||:.::.::.|.:.:...:.
Mouse   163 -----PDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTML 222

  Fly   229 MIGPVVGFFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLIGLFPK 289
            :.||..||..|......::|    .|....|...||||:||||.|:::.|.|:...|.|:..||:
Mouse   223 VFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQ 287

  Fly   290 QLPKVNASRTNSH---LPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPKLKDF 351
            .||..:.....|.   ||      :.|.:|.:        .||..|........:.:...:|:..
Mouse   288 SLPPHSDPGMESEQAMLP------EREYERPK--------PSNGVLRHPLEPDSSASCFQQLRVI 338

  Fly   352 PRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVVGL 416
            |:....||.|.:....:|:|...|...:||..||.||:|.||:....||..::|..:|....:|:
Mouse   339 PKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGI 403

  Fly   417 IGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPN----------TFSMTQAGQLNLT 471
            ...|:::.|...|....:...::|..:|....:|:.||.|..          ..:..:...|:..
Mouse   404 FLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVRYGNNSARGSALDPY 468

  Fly   472 SNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSKLYEDCSCVVNDPAPKSAAQRLLN 536
            |.||.||.|:..|:|||| .....|:.|||.|||...|.|.     |:|:...| |::|
Mouse   469 SPCNNNCECQTDSFTPVC-GADGITYLSACFAGCNSTNLTG-----CACLTTVP-PENA------ 520

  Fly   537 LLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGIC-TKNCNWSFWA 600
                                                          ||: ||.| :..|..:|..
Mouse   521 ----------------------------------------------SVV-PGKCPSPGCQEAFLT 538

  Fly   601 FSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGRLIDSTCLV 665
            |.....:.|..|:..:..:|::..|.|:.|.||:|.|:..:::.||..||.|:|||..||||||.
Mouse   539 FLCVMCVCSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLF 603

  Fly   666 WTKTCNGNGNCQLYDQTRFRY-SLNFLSCLLTFMGLLF 702
            |:..|...|.|.|||...:|| .::....|.:|..:|:
Mouse   604 WSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILY 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	183/667 (27%)
		MFS	40..>280	CDD:119392	73/249 (29%)
		DUF4064	364..447	CDD:290013	22/82 (27%)
		KAZAL_SLC21	470..521	CDD:238650	21/50 (42%)
Slco3a1	NP_076397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
Slco3a1	NP_076397.2	MFS_SLCO3_OATP3	39..563	CDD:340960	155/608 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750