DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and Slco4a1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001342147.1	Gene:	Slco4a1 / 108115	MGIID:	1351866	Length:	723	Species:	Mus musculus

Alignment Length:	755	Identity:	195/755 - (25%)
Similarity:	322/755 - (42%)	Gaps:	145/755 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PGHYLCGMANWHPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVT-LTTLEKRFKIPSQTTGII 76
            |.:.|||...:.|..||.:.|.|.|:........:|.|:...||.| :|::|:||.:.|..:|:|
Mouse    80 PQNSLCGWQAFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLI 144

  Fly    77 LSGNEISQIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDS 141
            .|..:|:..:....:||.||..::|||:.||::..|:...:..||||..|      ::..|..:.
Mouse   145 ASSYDIAACLCLTFVSYFGGNGHKPRWLGWGVLVLGIGSLVFALPHFTAG------RYEVEMDEG 203

  Fly   142 LLNGTTGSDHSFQNISSVKTERLCGVDKTEDDCDD----LFSYVPLVLIFLSQFVLGVGNTLYYS 202
            |..||                  |..:::..:|.|    |.:|  .::..|.|.:.|||.|..|:
Mouse   204 LGTGT------------------CLTNQSHVECKDSASGLSNY--RLIFMLGQLLHGVGATPLYT 248

  Fly   203 LGQTYLDDNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTPLIDSKDPRWLGAWW 267
            ||.||||:|.|.:.:|:.:|:.....::||..|:..|...||.:.:..:...:.:..|.|:||||
Mouse   249 LGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWW 313

  Fly   268 LGWVILGTLMCLFSGLIGL----FPKQLPKVNASRTNSHLPLALRQTK-EELKREENLSLSSRFS 327
            :|:  |||.:..|  ||.:    :|:|||       .|...:.:|..: ::||.....::|:
Mouse   314 IGF--LGTGIAAF--LIAIPILGYPRQLP-------GSQRYVVMRAAETQQLKDHSRGAVSN--- 364

  Fly   328 SNAALDTIGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQ 392
                     .|.|..     ::|.|.::..||||...|...|:........:|..||..|:.|.|
Mouse   365 ---------PAFGKT-----VRDLPLSIWLLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQ 415

  Fly   393 FHKDAQSATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFL-YC 456
            |...|..|..:.|.:.:.....|.:..|.:::|.|...|.::.:.:.....|:|.  .:.|| :|
Mouse   416 FSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLA--FFVFLMHC 478

  Fly   457 PNTF----------SMTQAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNAT 511
            ||..          |:...|||:|.:.||....|:...|:|:|.. ..|.::|.|:|||.....|
Mouse   479 PNVHMAGVTTGYVGSLLPKGQLDLKAACNAIYCCQPKHYSPLCGS-DGTMYYSPCYAGCPADAET 542

  Fly   512 ----SKLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQL 572
                .|:|..|||::.
Mouse   543 DLGGQKVYRGCSCILE------------------------------------------------- 558

  Fly   573 LSRTRRSTSDSVIRPGICTKNC-NWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQ 636
                :.|:.......|.|...| :..|....:..:|:..|.||  :..:....|.|:...:|||.
Mouse   559 ----KASSGWGNATAGKCASTCQSKPFLLVLVFVVIIFTFLSS--IPALTATLRCVSDRQRSFAL 617

  Fly   637 GLALMMISLLALIPGPIIFGRLIDSTCLVWTKTCNGNGNCQLYD-QTRFRYSLNFLSCLLTF--M 698
            |:..:::..|..|||||.||.:||..||:|...|...|:|.:|: :...||   .|...|||  :
Mouse   618 GIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYENEAMSRY---MLIAGLTFKVL 679

  Fly   699 GLLFDYLVWYYGRNLDIYGD-KEAKEEERANRKDQPITPL 737
            |.||....::..::..:..| .||....:::..|.|...|
Mouse   680 GFLFFVAAYFLYKSPSVSSDGLEASLPSQSSASDSPTEQL 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	171/674 (25%)
		MFS	40..>280	CDD:119392	71/244 (29%)
		DUF4064	364..447	CDD:290013	18/82 (22%)
		KAZAL_SLC21	470..521	CDD:238650	18/54 (33%)
Slco4a1	NP_001342147.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..64
		OATP	103..665	CDD:308646	171/673 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..723		5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810