Protein Alignment Oatp33Ea and Slco2b1

DIOPT Version :10

• Sequence 1: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: XP_011239939.1
• Gene: Slco2b1 / 101488
• MGIID: 1351872
• Length: 697
• Species: Mus musculus
• Alignment Length: 719
• Identity: 179/719 - (24%)
• Similarity: 290/719 - (40%)
• Gaps: 165/719 - (22%)

  Fly    35 KMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRN 99
            |.|:..:.||...|.|...|...:::|:||||.:.||.:|::.:.||:..:.|.|.:||.|.:.:
Mouse    55 KFFVLCHSLLQLTQLMISGYLKSSISTVEKRFGLSSQISGLLAAFNEVGNVSLILFVSYFGSRVH 119

  Fly   100 RPRWIAWGIVFCGLSCYILVLPHFI---YGAGHE-------------VLQFTKEYQDSLLNGTTG 148
            |||.|.:|.:....:..::.|||||   |...|.             .|..|.....:|.||:..
Mouse   120 RPRMIGYGALLVATAGLLMALPHFISEPYRYDHSSSDNRSLDFEASLCLPTTMAPASALSNGSCS 184

  Fly   149 SDHSFQNISSVKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTK 213
            |....::::.|.                        ::|.:|.:||:|.......|.:|:||...
Mouse   185 SHTETKHLTMVG------------------------IMFAAQTLLGIGGVPIQPFGISYIDDFAH 225

  Fly   214 KTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTKTP----LIDSKDPRWLGAWWLGWVILG 274
            .:|:||.:.:...:..:||.:.:..|.:.|..::|..:.|    .:..|||||:||||||::|..
Mouse   226 HSNSPLYIGILFGITTMGPGLAYGLGSLMLRLYVDIDRMPEGGINLTPKDPRWVGAWWLGFLISS 290

  Fly   275 TLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEE--LKREENLSLSSRFSSNAAL----D 333
            .|:.|.|.....||:::||                .|.|  .:|:...|.:|..|....|    :
Mouse   291 GLVVLASSPYFFFPREMPK----------------EKHEFHFRRKVLASAASTASKGEDLSSQHE 339

  Fly   334 TIGAAAGANADLPKL------KDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQ 392
            .:...||.....|.|      |.|||.|:|.||:.:.:..:||.|......:|..|||.|::|.|
Mouse   340 PLKKQAGLAQIAPDLTLVQFVKVFPRVLLRNLRHPIFLLVVLSQVCTSSMVAGMATFLPKFLERQ 404

  Fly   393 FHKDAQSATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCP 457
            |...|..|.:::|.::|..::||::..|::       |.::.:..|....:.:||.:.......|
Mouse   405 FSITASFANMLLGCLTIPLVIVGIMMGGVL-------VKRLHLSPVQCSALCLLGSLLCLLFSVP 462

  Fly   458 NTFSMTQAGQL-------------NLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRG-- 507
            ..|......|:             :|...|:..|||:...:.|||.......:.:.|||||.|
Mouse   463 LFFIGCSTHQIAGITQDLGAQPGPSLFPGCSEPCSCQSDDFNPVCDTSAYVEYTTPCHAGCTGRV 527

  Fly   508 -YNATSK---LYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDF 568
             ..|..|   .|.:||||..                                         ||
Mouse   528 VQEALGKSQVFYTNCSCVAG-----------------------------------------NG-- 549

  Fly   569 DDQLLSRTRRSTSDSVIRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKS 633
                           .:..|.|...|:.....|.:...:.:...|.....:.::..|.|..|||:
Mouse   550 ---------------TVPAGSCESACSRLVLPFIVLFSLGAGLASITHTPSFMLILRGVKKEDKT 599

  Fly   634 FAQGLALMMISLLALIPGPIIFGRLIDSTCLVWTKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFM 698
            .|.|:..|::.:||.:|.|:|.|..||:||:.|..||.....|:.||....|.         .|:
Mouse   600 LAVGMQFMLLRVLAWMPSPVIHGSAIDTTCVHWALTCGRRAVCRYYDHDLLRN---------RFI 655

  Fly   699 GLLF 702
            ||.|
Mouse   656 GLQF 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	173/698 (25%)
Slco2b1	XP_011239939.1	MFS	54..591	CDD:475125	150/640 (23%)