Protein Alignment Oatp33Ea and slco4c1

DIOPT Version :10

• Sequence 1: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: XP_002933490.4
• Gene: slco4c1 / 100485817
• XenbaseID: XB-GENE-983309
• Length: 783
• Species: Xenopus tropicalis
• Alignment Length: 711
• Identity: 192/711 - (27%)
• Similarity: 317/711 - (44%)
• Gaps: 133/711 - (18%)

  Fly    18 CGMANWHPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFI-VTLTTLEKRFKIPSQTTGIILSGNE 81
            ||..::.|..:|.....|.::.:|.||..:|..:....: |.::|:||||.:.|..||:|.:..:
 Frog   157 CGWGSFTPSCVQCCNNPKGYLVMYSLLAVMQGTAVNGLVNVVISTIEKRFDLNSSLTGLIAASYD 221

  Fly    82 ISQIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHF---IYGAGHEVLQFTKEYQDSLL 143
            |:..:|||.:|:.|.:.::|||:|:..:..||...:..:|:|   ||..|::|..|.:
 Frog   222 IAFCLLSLFVSFYGQRGHKPRWLAFSALMIGLGSLVFSIPNFFSGIYEYGNKVSDFCE------- 279

  Fly   144 NGTTGSDHSFQNISSVKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYL 208
              .:|:..|.||.|:..::                ||. |.:..|.|.::|||.|..|:||..|.
 Frog   280 --VSGNSSSLQNCSAGSSQ----------------SYF-LYVFVLGQLLMGVGGTPLYTLGTAYF 325

  Fly   209 DDNTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTK--TPLIDSKDPRWLGAWWLGWV 271
            ||:.....:.|.:.:|..:.::||.:|:..|...||.:||..|  :..|...|||||||||:|::
 Frog   326 DDSLPPHKSSLYIGIAYGMSVVGPAIGYLVGGQLLNIYIDIDKGQSVNITETDPRWLGAWWIGFL 390

  Fly   272 ILGTLMCLFSGLIGLFPKQLP---KVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALD 333
            |.|.:..|.......|||.||   |:.:.|.:.    |.....|.:...:||..|
 Frog   391 ICGLVTWLLIAPFSCFPKHLPGTEKMQSERISQ----AHNNGSESIVESKNLGKS---------- 441

  Fly   334 TIGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQ 398
                          .||||.||:.|::|.:||....::.|.....:.|..||.|::|.||...:.
 Frog   442 --------------FKDFPLALLLLVKNPVLISLTFASCFDAFITTAFAAFLPKFIENQFSLTSS 492

  Fly   399 SATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYCPN----- 458
            .:.|:.|.:.|....:|.:..|:::||.|.....::.:::|:..||:.....:.|..|.|
 Frog   493 FSAILGGGVLIPAAAIGQVLGGVIVSKCKFDCKNIIKFSIIITVISLALASVFIFARCGNDPFAG 557

  Fly   459 -TFSMTQAGQL-NLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRG--YNATSKLYEDCS 519
             :......|:: .|.:.||.||||....|.|||.. ....:||:|:|||..  ||...|:|.:||
 Frog   558 VSVQYNGTGKIGELDAPCNSNCSCARFFYDPVCGS-DGVQYFSSCYAGCTSVEYNDKGKIYGNCS 621

  Fly   520 CVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSV 584
            |:.:                                        ..|:|...:.|:..:
 Frog   622 CIAS----------------------------------------HTGEFGVNVTSQAEQ------ 640

  Fly   585 IRPGICTKNCN--WSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLA 647
               |.|...||  .:|..|....::.::..::.....:|   |.|..:.:|||.|:...:|.||.
 Frog   641 ---GKCEAKCNNLITFMVFFFFVVVATFMTATPITMAIL---RCVPDKQRSFALGVQWSLIRLLG 699

  Fly   648 LIPGPIIFGRLIDSTCLVWT-KTCNGNGNCQLYDQTRFRYSLNFLSC-----LLTFMGLLF 702
            .|||||:||.:|||:|::|. ..|...|.|..|..:....:|.|:|.     .:.|:.:.|
 Frog   700 SIPGPIVFGVVIDSSCILWNINECGVEGACWTYKNSEMSLNLVFISAACKVLTIAFLSIAF 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	182/668 (27%)
slco4c1	XP_002933490.4	MFS_SLCO4C_OATP4C	173..677	CDD:341021	158/610 (26%)