Protein Alignment Oatp33Ea and slco1e1

DIOPT Version :10

• Sequence 1: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: XP_009299376.2
• Gene: slco1e1 / 100332946
• ZFINID: ZDB-GENE-100818-2
• Length: 695
• Species: Danio rerio
• Alignment Length: 761
• Identity: 194/761 - (25%)
• Similarity: 308/761 - (40%)
• Gaps: 174/761 - (22%)

  Fly     1 MAEVKRRDPNRPPGHY-LCGMANWHPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVTL----- 59
            |:|....|..:|.... ||..   ..|...:.::.|:|:|         |:|:.||..||
Zfish     1 MSEPTIEDNGKPTSQQELCSP---EAPEEPRCSSLKIFIG---------ALSFAYFSKTLCGTYM 53

  Fly    60 ----TTLEKRFKIPSQTTGIILSGNEISQIMLSLILSYIGGQRNRPRWIAWGIVFCGLSCYILVL 120
                |.:|:||.:.|...|::....|:..::...::|:.|.:.:|||.|       |:.|:::.:
Zfish    54 KSAITQIERRFDLSSSAVGLVDGSFEMGNLLFVAVVSHFGARLHRPRLI-------GMGCFLMAI 111

  Fly   121 PHFIYGAGHEVLQFTKEYQ-DSLLNG--------------TTGSDHSFQNISSVKTERLCGVDKT 170
            ...:.|..|   .|...|: |:.:.|              |..|:||.|:|     :...|.|..
Zfish   112 GSALTGLPH---VFMGRYKFDTAVQGFANETVVIAPCQYPTNPSEHSIQHI-----DNTTGTDCV 168

  Fly   171 EDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTKKTNTPLMLAVAMALRMIGPVVG 235
            :|....::.||     ||...:.|:|.|....||.:|:||..|..|:...::....:.::||:.|
Zfish   169 KDPGSSMWIYV-----FLGNALRGIGETPVTPLGISYIDDFAKAENSAFYISCLQTIMLLGPMFG 228

  Fly   236 FFFGFISLNTFID----PTKTPLIDSKDPRWLGAWWLGWVILGTLMCLFSGLIGLFPKQLPKVNA 296
            |..|.:....::|    ...:..|..:|.||:||||||:.:....:.|........|:.|||
Zfish   229 FLLGSMCAKLYVDIGFVSVDSVSITPQDARWVGAWWLGFFVSSAFLVLSGVPFWFLPRSLPK--- 290

  Fly   297 SRTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDTIGAAAGANADLPKLKDFPRALMRLLRN 361
                        |.:||.:.......:...|......|:..|..|...||.||       |||..
Zfish   291 ------------QGEEEKEIYNTDDANKEHSVLQTTHTMTLADIAKGFLPSLK-------RLLCT 336

  Fly   362 KLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQSATIIVGPISIMGMVVGLIGSGMVLSKK 426
            ......:...|.......|.:||..||||.||.:.|..|..::|.:.:..:.||:...|:::.|.
Zfish   337 PAYFLLLCGIVLKFNSFIGLLTFKAKYMEQQFGQSASRANFLIGVLILPVVAVGIFLGGLLMKKY 401

  Fly   427 KPSV-------------SKVLMW--------NVIVGGISILGQISYAFLYCPNTFSMTQAGQLNL 470
            |.||             :.:|:.        ||.|.|::    :||      |......:.|.:|
Zfish   402 KLSVVAGAQLSFITSFTAFLLLLLHFGTKCDNVPVAGLT----VSY------NGTPYMPSDQRSL 456

  Fly   471 TSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRGYNATSK--LYEDCSCVVNDPAPKSAAQR 533
            .|.||.:|||....:.|||.: :..|:.|.|.|||.......|  ::.:||||
Zfish   457 ESQCNQDCSCSTSEWDPVCSD-SGITYMSPCLAGCTASTGQGKNTVFHNCSCV------------ 508

  Fly   534 LLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTSDSVIRPGICTKN--CNW 596
                |.|:|.                    :.|           ||.|     .|.|.:.  |..
Zfish   509 ----LSPSPA--------------------EGG-----------RSVS-----LGQCPQGSACAR 533

  Fly   597 SFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLLALIPGPIIFGRLIDS 661
            ||.::...|::.|:..|.|.....::..|.:|.|.||.|.|:..:::..|..||.||.||.|||:
Zfish   534 SFTSYMAVSVLSSFINSLGTTPGYMIIIRCIAPELKSLALGIQTLVMRTLGGIPAPIYFGALIDT 598

  Fly   662 TCLVW-TKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLV 706
            |||.| .|.|.|.|.|::||...:|  :.|||......|..:.:::
Zfish   599 TCLKWGLKKCGGRGACRIYDSNMYR--VIFLSLTTALSGCSYFFII 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	181/701 (26%)
slco1e1	XP_009299376.2	None