DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and slco1f2

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	NP_001121745.2	Gene:	slco1f2 / 100190901	ZFINID:	ZDB-GENE-080305-3	Length:	662	Species:	Danio rerio

Alignment Length:	761	Identity:	194/761 - (25%)
Similarity:	320/761 - (42%)	Gaps:	181/761 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PPWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLSL 89
            ||.|      |:|:.........::|:..|...|:|.:|:||:|||.|.|||..|.|:..:::..
Zfish    24 PPRL------KIFIAALAFCYFSKSMTASYTKSTITQIERRFEIPSSTVGIIDGGFEMGNMLVIT 82

  Fly    90 ILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYG-------AGHEVLQFTKEYQDSLLNGTT 147
            ::||:|.:.:||:.|..|::..|:...::..||||.|       |.|     |.:..:..:..|.
Zfish    83 LVSYVGAKFHRPKIIGAGVLLMGIGTLLMASPHFIMGRYKYGTAATH-----TNDAGNFTVISTC 142

  Fly   148 GSDHSFQNISSVKT--ERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDD 210
            .||       |.||  :...|..|.|.:...|:     |::.|...:||:|......||.:::||
Zfish   143 SSD-------SQKTLQQPFSGCRKEEAESSPLW-----VIVVLGNTMLGIGEASIIPLGMSFVDD 195

  Fly   211 NTKKTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFID--------PTKTPLIDSKDPRWLGAWW 267
            ..:..|:...:.....::.|||:.||..|.:..|.::|        .|.||    :|.||:||||
Zfish   196 YARPENSAFYIGCLNTIKGIGPIFGFVLGSLCANLYVDIGLVNKESVTITP----QDSRWVGAWW 256

  Fly   268 LGWVILGTLMCLFSGLIGLFPKQLPKVNASRTNSHLPLALRQTKEELKREENLSLSSRFSSNAAL 332
            ||:|:.|.|..|.:......||.||:      ||.:.| |..|.::.|...:|:
Zfish   257 LGYVVSGLLTVLAAFPFWFLPKALPE------NSQISL-LDNTPQQHKTTPSLT----------- 303

  Fly   333 DTIGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDA 397
                         ..:|||.....|||.||:.|..:..::......:..:|:..||:|.||.:.|
Zfish   304 -------------EIVKDFAPTFKRLLTNKIYILYLAYSIVAFNDFAILVTYTPKYLEQQFGQSA 355

  Fly   398 QSATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGG-ISILGQISYAFLYCPNTFS 461
            ..|..::|...:..:.:|:..||:::.:.|        |.::... :::|..::..||..| .|:
Zfish   356 SKANFLIGVTCVPAVALGVFLSGLMMKRFK--------WGLLASARVNLLTIVATVFLTVP-FFA 411

  Fly   462 MT-------------------QAGQLNLTSNCNMNCSCEGISYTPVCHEPTDTTFFSACHAGCRG 507
            ::                   |....::..:||.:|.|..:.:.|||.| ...|:.|.|||||..
Zfish   412 LSCENLDIAGVTVPYQGSTEVQGVTSDVLPSCNADCGCPDLHWDPVCGE-NGVTYISPCHAGCSS 475

  Fly   508 YNAT--SKLYEDCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDD 570
            ....  :|.:.||.|:.:                                 .|:.:
Zfish   476 TQGAGRNKTFHDCGCIQS---------------------------------WGLSV--------- 498

  Fly   571 QLLSRTRRSTSDSVIRPGICTK--NCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKS 633
                    ..|.:|:  |.|::  |||...:.:.....:..:..|.|.|....::.|.|..|.||
Zfish   499 --------GNSSAVL--GQCSQNPNCNRMMYLYLGLQSLALFVYSLGAVPLFTMSLRIVDPELKS 553

  Fly   634 FAQGLALMMISLLALIPGPIIFGRLIDSTCLVW--TKTCNGNGNCQLYDQTRFRY-------SLN 689
            .:.|:.|:.|.:|..||.||.||.|:||:||.|  .|:| |.|.|::||...||:       .|.
Zfish   554 LSVGVLLLSIRVLGGIPAPIYFGALVDSSCLKWGQRKSC-GRGACRIYDIETFRFLFQGLTNCLR 617

  Fly   690 FLSCLLTFMGLLFDYLVWYYGRNLDIYGDKEAKEEERANR--KDQP 733
            .|:|     .||:...:|...:   |..||:..|:....|  .|.|
Zfish   618 VLAC-----SLLWIATIWIKRK---IQNDKQISEDMELQRGPSDDP 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	175/690 (25%)
		MFS	40..>280	CDD:119392	75/256 (29%)
		DUF4064	364..447	CDD:290013	15/83 (18%)
		KAZAL_SLC21	470..521	CDD:238650	18/52 (35%)
slco1f2	NP_001121745.2	OATP	29..605	CDD:281175	175/690 (25%)
		MFS	31..>413	CDD:119392	115/442 (26%)
		KAZAL_SLC21	440..492	CDD:238650	19/52 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D434101at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920