DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp33Ea and slco2b1

DIOPT Version :9

Sequence 1:	NP_001260417.1	Gene:	Oatp33Ea / 34660	FlyBaseID:	FBgn0032433	Length:	745	Species:	Drosophila melanogaster
Sequence 2:	XP_031751477.1	Gene:	slco2b1 / 100125037	XenbaseID:	XB-GENE-6046634	Length:	663	Species:	Xenopus tropicalis

Alignment Length:	745	Identity:	201/745 - (26%)
Similarity:	325/745 - (43%)	Gaps:	142/745 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 HPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLS 88
            ||     :...|:|:..:|.|...|.:...|...:::|:||||.|.|||:||:.|.|||...:|.
Frog    30 HP-----FNNIKVFVLCHGFLQLSQLLLSGYLRSSISTIEKRFGISSQTSGILSSFNEIGNTVLI 89

  Fly    89 LILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGT-----TG 148
            :.:||.|.:.:|||:|..|.:....:.:::.|||||.|.    .::.|.....|.|.|     .|
Frog    90 VFVSYFGSRVHRPRFIGCGAIIVCAAGFLMSLPHFIMGP----YEYDKSVASLLSNVTDICQPNG 150

  Fly   149 SDHSFQNISSVKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTK 213
            ...|..|...|:     ||.|...:.        |.::||.|.:||:|:......|.:|:||...
Frog   151 PIKSSDNDQCVE-----GVQKANKNV--------LFILFLGQILLGIGSVPIQPFGISYIDDFAS 202

  Fly   214 KTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTK--------TPLIDSKDPRWLGAWWLGW 270
            |.|:||.:.:..|:.::||.|.|..|...|..::|..|        ||    |||||:||||||:
Frog   203 KRNSPLYIGILFAVTVMGPGVAFILGSAMLRFYVDIDKLSADEITLTP----KDPRWIGAWWLGY 263

  Fly   271 VILGTLMCLFSGLIGLFPKQLPKVNAS-RTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDT 334
            ::.|:::.:.|....:||:::||...| :.....|..:.:.|.:.:..|.|:| |:|
Frog   264 LVAGSVVAIASIPYFIFPREMPKQGPSEKPEEPKPSLMDEIKSKTEENEKLTL-SQF-------- 319

  Fly   335 IGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQS 399
                         :|.||:.|.|.::|.:.|..:|:.........|..||:.|::|.||...|..
Frog   320 -------------IKVFPKVLFRTVKNPVFILIVLAQGNMSAMVCGLATFMAKFLERQFSITASL 371

  Fly   400 ATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYC-------P 457
            |.:::|..:|...:.|::..|:::.:.:.:..:..:..||...|.|...|...||.|       |
Frog   372 ANLLIGSANIPAAMSGIVLGGIIMKRHRLTPKQSALMCVIGLIICIFTAIPLVFLGCSTQQFASP 436

  Fly   458 NTFSMTQAGQLNLTSNCNMNCSCEGISYTPVCHEPTD-TTFFSACHAGCR----GYNATSKL-YE 516
            .......:|.....|.|:..|.|...::.|||  .|| ..:.|.|:|||.    |.:.|..| |.
Frog   437 RMDHQGSSGIWQNVSECSGGCQCSSAAFNPVC--GTDGVEYISPCYAGCGAVQFGESPTEVLNYT 499

  Fly   517 DCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTS 581
            .|:|:   ||..||
Frog   500 RCTCI---PAAGSA--------------------------------------------------- 510

  Fly   582 DSVIRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLL 646
                :||.|...|......|.:.|.:.....|..:..:.::..|:|...|||.|.|:..|::.:|
Frog   511 ----KPGSCGTVCGQLLVPFMVLSCLAGGLASMAQTPSFMLILRSVKPTDKSLAIGIQFMLLRIL 571

  Fly   647 ALIPGPIIFGRLIDSTCLVWTKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGR 711
            |.:|||:::|.:|||||::|.:.|....:||.||....|.....|..|....||:|...|::..|
Frog   572 AWLPGPVMYGSVIDSTCILWGQKCGKKTSCQYYDNNLLRQRFIGLQILFEIGGLIFFTAVFFVLR 636

  Fly   712 NLDIYGDKEAKEEERANRKDQPITPLLAKK 741
            .      :|....|::.| :.|.|..|.::
Frog   637 R------REKVSAEKSMR-ENPETHALTQE 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_001260417.1	OATP	36..684	CDD:281175	184/674 (27%)
		MFS	40..>280	CDD:119392	83/252 (33%)
		DUF4064	364..447	CDD:290013	19/82 (23%)
		KAZAL_SLC21	470..521	CDD:238650	19/56 (34%)
slco2b1	XP_031751477.1	MFS	35..550	CDD:421695	160/617 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1029129at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010