Protein Alignment Oatp33Ea and slco2b1

DIOPT Version :10

• Sequence 1: NP_609568.3
• Gene: Oatp33Ea / 34660
• FlyBaseID: FBgn0032433
• Length: 745
• Species: Drosophila melanogaster
• Sequence 2: XP_031751477.1
• Gene: slco2b1 / 100125037
• XenbaseID: XB-GENE-6046634
• Length: 663
• Species: Xenopus tropicalis
• Alignment Length: 745
• Identity: 201/745 - (26%)
• Similarity: 325/745 - (43%)
• Gaps: 142/745 - (19%)

  Fly    24 HPPWLQKYATTKMFMGVYGLLGTIQAMSYMYFIVTLTTLEKRFKIPSQTTGIILSGNEISQIMLS 88
            ||     :...|:|:..:|.|...|.:...|...:::|:||||.|.|||:||:.|.|||...:|.
 Frog    30 HP-----FNNIKVFVLCHGFLQLSQLLLSGYLRSSISTIEKRFGISSQTSGILSSFNEIGNTVLI 89

  Fly    89 LILSYIGGQRNRPRWIAWGIVFCGLSCYILVLPHFIYGAGHEVLQFTKEYQDSLLNGT-----TG 148
            :.:||.|.:.:|||:|..|.:....:.:::.|||||.|.    .::.|.....|.|.|     .|
 Frog    90 VFVSYFGSRVHRPRFIGCGAIIVCAAGFLMSLPHFIMGP----YEYDKSVASLLSNVTDICQPNG 150

  Fly   149 SDHSFQNISSVKTERLCGVDKTEDDCDDLFSYVPLVLIFLSQFVLGVGNTLYYSLGQTYLDDNTK 213
            ...|..|...|:     ||.|...:.        |.::||.|.:||:|:......|.:|:||...
 Frog   151 PIKSSDNDQCVE-----GVQKANKNV--------LFILFLGQILLGIGSVPIQPFGISYIDDFAS 202

  Fly   214 KTNTPLMLAVAMALRMIGPVVGFFFGFISLNTFIDPTK--------TPLIDSKDPRWLGAWWLGW 270
            |.|:||.:.:..|:.::||.|.|..|...|..::|..|        ||    |||||:||||||:
 Frog   203 KRNSPLYIGILFAVTVMGPGVAFILGSAMLRFYVDIDKLSADEITLTP----KDPRWIGAWWLGY 263

  Fly   271 VILGTLMCLFSGLIGLFPKQLPKVNAS-RTNSHLPLALRQTKEELKREENLSLSSRFSSNAALDT 334
            ::.|:::.:.|....:||:::||...| :.....|..:.:.|.:.:..|.|:| |:|
 Frog   264 LVAGSVVAIASIPYFIFPREMPKQGPSEKPEEPKPSLMDEIKSKTEENEKLTL-SQF-------- 319

  Fly   335 IGAAAGANADLPKLKDFPRALMRLLRNKLLIFNILSAVFYILGASGFMTFLTKYMEVQFHKDAQS 399
                         :|.||:.|.|.::|.:.|..:|:.........|..||:.|::|.||...|..
 Frog   320 -------------IKVFPKVLFRTVKNPVFILIVLAQGNMSAMVCGLATFMAKFLERQFSITASL 371

  Fly   400 ATIIVGPISIMGMVVGLIGSGMVLSKKKPSVSKVLMWNVIVGGISILGQISYAFLYC-------P 457
            |.:::|..:|...:.|::..|:::.:.:.:..:..:..||...|.|...|...||.|       |
 Frog   372 ANLLIGSANIPAAMSGIVLGGIIMKRHRLTPKQSALMCVIGLIICIFTAIPLVFLGCSTQQFASP 436

  Fly   458 NTFSMTQAGQLNLTSNCNMNCSCEGISYTPVCHEPTD-TTFFSACHAGCR----GYNATSKL-YE 516
            .......:|.....|.|:..|.|...::.|||  .|| ..:.|.|:|||.    |.:.|..| |.
 Frog   437 RMDHQGSSGIWQNVSECSGGCQCSSAAFNPVC--GTDGVEYISPCYAGCGAVQFGESPTEVLNYT 499

  Fly   517 DCSCVVNDPAPKSAAQRLLNLLQPTPEPELDTTTYFDEYLSGVPLLDDNGDFDDQLLSRTRRSTS 581
            .|:|:   ||..||
 Frog   500 RCTCI---PAAGSA--------------------------------------------------- 510

  Fly   582 DSVIRPGICTKNCNWSFWAFSITSMIVSWFGSSGRVGNVLVNYRAVAHEDKSFAQGLALMMISLL 646
                :||.|...|......|.:.|.:.....|..:..:.::..|:|...|||.|.|:..|::.:|
 Frog   511 ----KPGSCGTVCGQLLVPFMVLSCLAGGLASMAQTPSFMLILRSVKPTDKSLAIGIQFMLLRIL 571

  Fly   647 ALIPGPIIFGRLIDSTCLVWTKTCNGNGNCQLYDQTRFRYSLNFLSCLLTFMGLLFDYLVWYYGR 711
            |.:|||:::|.:|||||::|.:.|....:||.||....|.....|..|....||:|...|::..|
 Frog   572 AWLPGPVMYGSVIDSTCILWGQKCGKKTSCQYYDNNLLRQRFIGLQILFEIGGLIFFTAVFFVLR 636

  Fly   712 NLDIYGDKEAKEEERANRKDQPITPLLAKK 741
            .      :|....|::.| :.|.|..|.::
 Frog   637 R------REKVSAEKSMR-ENPETHALTQE 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp33Ea	NP_609568.3	OATP	36..684	CDD:460821	184/674 (27%)
slco2b1	XP_031751477.1	MFS	35..550	CDD:475125	160/617 (26%)