DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eRF3 and TEF2

DIOPT Version :9

Sequence 1:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_009676.1	Gene:	TEF2 / 852415	SGDID:	S000000322	Length:	458	Species:	Saccharomyces cerevisiae

Alignment Length:	450	Identity:	171/450 - (38%)
Similarity:	262/450 - (58%)	Gaps:	35/450 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 KREHVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRESWYLSWALDTNQEERD 256
            ::.|:|||.|||||:||||..|.::...|.:||||:||:|:||.|..:.|:..:|.||..:.||:
Yeast     4 EKSHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERE 68

  Fly   257 KGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQT 321
            :|.|:::....|||.:...|::|||||:.|:.|||.|.:|||.|:|:|:...||||.|..:.|||
Yeast    69 RGITIDIALWKFETPKYQVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGVGEFEAGISKDGQT 133

  Fly   322 REHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNPAKDLTFMPCSGLS 386
            ||||:||.|.||:.|:|.|||||  :|.||::|:.|...:...::||:|:|| |.:.|:|.||.:
Yeast   134 REHALLAFTLGVRQLIVAVNKMD--SVKWDESRFQEIVKETSNFIKKVGYNP-KTVPFVPISGWN 195

  Fly   387 GYGLKDQIPE--TLCPWY------------RGPAFIPFIDELPSLNRKSDGPFIMPIVDKYK--D 435
            |    |.:.|  |..|||            :|...:..||.:...:|.:|.|..:|:.|.||  .
Yeast   196 G----DNMIEATTNAPWYKGWEKETKAGVVKGKTLLEAIDAIEQPSRPTDKPLRLPLQDVYKIGG 256

  Fly   436 MGTVVMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSPG 500
            :|||.:|:||:|..:.|..:...|......|..:.....::....||:||...:|.:..:::..|
Yeast   257 IGTVPVGRVETGVIKPGMVVTFAPAGVTTEVKSVEMHHEQLEQGVPGDNVGFNVKNVSVKEIRRG 321

  Fly   501 FVLCDAAN-PIKTGKIFDAQVVILEHKSIICAGYSAVM-----HIHCAAEEVTVKALICLVDKKS 559
            .|..||.| |.|....|:|.|::|.|...|.||||.|:     ||.|..:|:..|.     |::|
Yeast   322 NVCGDAKNDPPKGCASFNATVIVLNHPGQISAGYSPVLDCHTAHIACRFDELLEKN-----DRRS 381

  Fly   560 GDKSKTRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVVE 619
            |.|.:..|:|:|....|:::...|..:|:|.|..:|.:|||.:||..:|:|:| |:|.|:
Yeast   382 GKKLEDHPKFLKSGDAALVKFVPSKPMCVEAFSEYPPLGRFAVRDMRQTVAVG-VIKSVD 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	170/448 (38%)
		EF1_alpha	197..416	CDD:206670	101/232 (44%)
		eRF3_II	424..505	CDD:293906	22/82 (27%)
		eRF3_C_III	511..617	CDD:294003	39/110 (35%)
TEF2	NP_009676.1	PTZ00141	1..443	CDD:185474	171/449 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
TreeFam	0	0.000	Not matched by this tool.
	3	2.810