DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eRF3 and eef1a1

DIOPT Version :9

Sequence 1:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001016692.1	Gene:	eef1a1 / 549446	XenbaseID:	XB-GENE-480094	Length:	462	Species:	Xenopus tropicalis

Alignment Length:	449	Identity:	170/449 - (37%)
Similarity:	260/449 - (57%)	Gaps:	31/449 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 KREHVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRESWYLSWALDTNQEERD 256
            ::.|:|:|.|||||:||||..|.::...|.:||||:||:|:||.|..:.|:..:|.||..:.||:
Frog     4 EKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERE 68

  Fly   257 KGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQT 321
            :|.|:::....|||.:.:.||:|||||:.|:.|||.|.:|||.|||:::|..||||.|..:.|||
Frog    69 RGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQT 133

  Fly   322 REHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNPAKDLTFMPCSGLS 386
            ||||:||.|.|||.|:|.|||||.....:.|.||.|...::..|:||:|:|| ..:.|:|.||.:
Frog   134 REHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNP-DTVAFVPISGWN 197

  Fly   387 GYGLKDQIPETLCPWYR------------GPAFIPFIDELPSLNRKSDGPFIMPIVDKYK--DMG 437
            |..:.:  |....||::            |...:..:|.:...:|.:|.|..:|:.|.||  .:|
Frog   198 GDNMLE--PSANMPWFKGWKISRKEGSGSGTTLLEALDCILPPSRPTDKPLRLPLQDVYKIGGIG 260

  Fly   438 TVVMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSPGFV 502
            ||.:|:||:|..:.|..:...|......|..:......::...||:||...:|.:..:||..|.|
Frog   261 TVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEAMPGDNVGFNVKNVSVKDVRRGNV 325

  Fly   503 LCDAAN--PIKTGKIFDAQVVILEHKSIICAGYSAVM-----HIHCAAEEVTVKALICLVDKKSG 560
            ..|:.|  |::.| .|.|||:||.|...|.|||:.|:     ||.|...|:..|     :|::||
Frog   326 AGDSKNDPPMEAG-TFTAQVIILNHPGQIGAGYAPVLDCHTAHIACKFAELKEK-----IDRRSG 384

  Fly   561 DKSKTRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVVE 619
            .|.:..|:|:|....||:.:.....:|:|.|..:|.:|||.:||..:|:|:| |:|.|:
Frog   385 KKLEDNPKFLKSGDAAIVDMIPGKPMCVESFSDYPPLGRFAVRDMRQTVAVG-VIKAVD 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	169/447 (38%)
		EF1_alpha	197..416	CDD:206670	98/230 (43%)
		eRF3_II	424..505	CDD:293906	24/82 (29%)
		eRF3_C_III	511..617	CDD:294003	40/110 (36%)
eef1a1	NP_001016692.1	PTZ00141	1..460	CDD:185474	170/449 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920