Protein Alignment eRF3 and Gspt2

DIOPT Version :10

• Sequence 1: NP_477259.1
• Gene: eRF3 / 34658
• FlyBaseID: FBgn0020443
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001102789.1
• Gene: Gspt2 / 501582
• RGDID: 1563213
• Length: 632
• Species: Rattus norvegicus
• Alignment Length: 634
• Identity: 362/634 - (57%)
• Similarity: 436/634 - (68%)
• Gaps: 66/634 - (10%)

  Fly     2 AAQENTEISTKFST-LNVNAVEFVPSFSYNSVVNVAEEAAAVVVAAAAAEETADPGPASGSATPA 65
            |..:...:|..||: ||:||..||||                 |:||....:..||.|...|..|
  Rat    44 AEAQRRHLSLAFSSQLNINAKPFVPS-----------------VSAAEFVPSFLPGSAQLPAPTA 91

  Fly    66 TTPDSVGSGGSTAGAAPPPPTAQGAGAAAPSAQPPTSS---SNSASPAPGSPATTPSAGAAAADP 127
            ::.|....||:   |.|.....:......||...|..|   ||||            .....::|
  Rat    92 SSCDETCIGGA---AEPQGKRMEWGAPVEPSKDGPLVSWEGSNSA------------VTMELSEP 141

  Fly   128 TPIDGLNPSDKIANNETDPA--DSWDVDDA-----------VITPEDEEVEDAEFTEGEATPKVS 179
            .          :.|.|.:.|  :||::.:.           |..||:...|..|..|     ::.
  Rat   142 V----------VENGEVEMALEESWELKEVSEAAPEGSLGDVGPPEESGKEVMEEKE-----EIR 191

  Fly   180 KKKVVKVEENRSKREHVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRESWYL 244
            |.|.|.......|:|||||||||||||||||||||||.||||||:||||||||||:||:||:|||
  Rat   192 KSKSVVRPSGAPKKEHVNVVFIGHVDAGKSTIGGQIMFLTGMVDRRTLEKYEREAKEKNRETWYL 256

  Fly   245 SWALDTNQEERDKGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKG 309
            ||||||||||||||||||||||:|||::||||||||||||||||||||||:||||||||||||||
  Rat   257 SWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKG 321

  Fly   310 EFETGFDRGGQTREHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNPA 374
            ||||||::|||||||||||||||||:|:||:||||||||:|...||.|||:|::|:|||:||:|.
  Rat   322 EFETGFEKGGQTREHAMLAKTAGVKYLIVLINKMDDPTVDWSSERYEECKEKLVPFLKKVGFSPK 386

  Fly   375 KDLTFMPCSGLSGYGLKDQIPETLCPWYRGPAFIPFIDELPSLNRKSDGPFIMPIVDKYKDMGTV 439
            ||:.|||||||:|..:|:|  ...||||.|..|||::|.||:.||..|||..:||||||||||||
  Rat   387 KDIHFMPCSGLTGANIKEQ--SDFCPWYTGLPFIPYLDSLPNFNRSIDGPIRLPIVDKYKDMGTV 449

  Fly   440 VMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSPGFVLC 504
            |:||:|||:..|||.|::|||:..|.|..:.|||.|...|.||||:||:|||||||::.|||:||
  Rat   450 VLGKLESGSIFKGQQLVMMPNKHSVEVLGIVSDDAETDFVAPGENLKIRLKGIEEEEILPGFILC 514

  Fly   505 DAANPIKTGKIFDAQVVILEHKSIICAGYSAVMHIHCAAEEVTVKALICLVDKKSGDKSKTRPRF 569
            :..|...:|:.||.|:||:|||||||.||:||:|||...|||.:.|||.|||||||:||||||||
  Rat   515 EPNNLCHSGRTFDVQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALISLVDKKSGEKSKTRPRF 579

  Fly   570 VKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVV 618
            ||||||.|.|:..:|.||||.||.||||||||||||.||||||||||:|
  Rat   580 VKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLV 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eRF3	NP_477259.1	PAM2	12..28	CDD:429316	10/16 (63%)
		EF1_alpha	197..416	CDD:206670	174/218 (80%)
		eRF3_II	424..505	CDD:293906	50/80 (63%)
		eRF3_C_III	511..617	CDD:294003	77/105 (73%)
Gspt2	NP_001102789.1	PAM2	55..71	CDD:429316	10/32 (31%)
		TEF1	202..631	CDD:444074	314/429 (73%)