Protein Alignment eRF3 and gspt1

DIOPT Version :10

• Sequence 1: NP_477259.1
• Gene: eRF3 / 34658
• FlyBaseID: FBgn0020443
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001003992.1
• Gene: gspt1 / 445485
• ZFINID: ZDB-GENE-040822-36
• Length: 564
• Species: Danio rerio
• Alignment Length: 618
• Identity: 363/618 - (58%)
• Similarity: 428/618 - (69%)
• Gaps: 78/618 - (12%)

  Fly     3 AQENTEISTKFSTLNVNAVEFVPSF-SYNSVVNVAEEAAAVVVAAAAAEETADP-GPASGSATPA 65
            |..:||:.:.|:.|||||.|||||| |.....|...:...||    |:.|.::| |......|.|
Zfish    19 ATADTELQSAFTGLNVNAPEFVPSFLSRGPPENATSDGTDVV----ASMEISEPVGAVENGETDA 79

  Fly    66 TTPDSVGSGGSTAGAAPPPPTAQGAGAAAPSAQPPTSSSNSASPAPGSPATTPSAGAAAADPTPI 130
            :..::....|                      :|     :...|..||||.|...|..|.|.
Zfish    80 SAVETWEQKG----------------------EP-----DKEEPGGGSPADTGCFGDEAQDE--- 114

  Fly   131 DGLNPSDKIANNETDPADSWDVDDAVITPEDEEVEDAEFTEGEATPKVSKKKVVKVEENRSKREH 195
                                      :..||||:         .|||:...     ..:..|:||
Zfish   115 --------------------------MMEEDEEM---------PTPKLPPP-----PPDAPKKEH 139

  Fly   196 VNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRESWYLSWALDTNQEERDKGKT 260
            |||||||||||||||||||||.|||||:|||||||||||:||:||:|||||||||||||||||||
Zfish   140 VNVVFIGHVDAGKSTIGGQIMYLTGMVEKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKT 204

  Fly   261 VEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQTREHA 325
            ||||||:|||::||||||||||||||||||||||:||||||||||||||||||||::||||||||
Zfish   205 VEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHA 269

  Fly   326 MLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNPAKDLTFMPCSGLSGYGL 390
            |||||||||||:||:||||||||||...||.|||:|::|:|||:||||.||:.|||||||:|..|
Zfish   270 MLAKTAGVKHLIVLINKMDDPTVNWSLDRYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANL 334

  Fly   391 KDQIPETLCPWYRGPAFIPFIDELPSLNRKSDGPFIMPIVDKYKDMGTVVMGKVESGTARKGQNL 455
            |:.  ..|||||.|..|||.:|.||..:|.||||..:|||||||||||||:||:|||:..|.|.|
Zfish   335 KES--SDLCPWYTGLPFIPHLDSLPIFSRSSDGPLRLPIVDKYKDMGTVVLGKLESGSIAKAQQL 397

  Fly   456 LVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSPGFVLCDAANPIKTGKIFDAQV 520
            ::||||..|.|..|.|||.|....|||||:|::|||||||::.|||:||:|.|...:|:.||||:
Zfish   398 IMMPNRHTVEVLSLLSDDVETEYAGPGENLKLRLKGIEEEEILPGFILCNAENLCHSGRTFDAQI 462

  Fly   521 VILEHKSIICAGYSAVMHIHCAAEEVTVKALICLVDKKSGDKSKTRPRFVKQDQVAIMRIECSGM 585
            ||:|||||||.||:||:|||...|||.:.|||||||||:|:||||||||||||||.|.|:..:|.
Zfish   463 VIIEHKSIICPGYNAVLHIHTCIEEVQISALICLVDKKTGEKSKTRPRFVKQDQVCIARLRAAGT 527

  Fly   586 ICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVV 618
            ||||.||.||||||||||||.||||||||||:|
Zfish   528 ICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLV 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eRF3	NP_477259.1	PAM2	12..28	CDD:429316	12/16 (75%)
		EF1_alpha	197..416	CDD:206670	178/218 (82%)
		eRF3_II	424..505	CDD:293906	50/80 (63%)
		eRF3_C_III	511..617	CDD:294003	78/105 (74%)
gspt1	NP_001003992.1	PAM2	<32..44	CDD:429316	10/11 (91%)
		TEF1	138..563	CDD:444074	319/425 (75%)