Protein Alignment eRF3 and hbs1l

DIOPT Version :10

• Sequence 1: NP_477259.1
• Gene: eRF3 / 34658
• FlyBaseID: FBgn0020443
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001295477.1
• Gene: hbs1l / 324267
• ZFINID: ZDB-GENE-030131-2987
• Length: 682
• Species: Danio rerio
• Alignment Length: 625
• Identity: 206/625 - (32%)
• Similarity: 321/625 - (51%)
• Gaps: 61/625 - (9%)

  Fly     7 TEISTKFSTLNVNAVEFVPSFSYNSVVNVAEEAAAVVVAAAAAEETADPGPASGS-----ATPAT 66
            |:.:.|:......|::|:.|.:.|:....|.....:.....||.:.|....|..|     ..|..
Zfish   107 TQAALKYDCDPHRALDFILSENTNTQAPSARTNPQLEPNTTAAPQKAKVREAPESRVESEVVPKV 171

  Fly    67 TPDSVGSGGSTAGAAPPPPTAQGAGAAAPSAQPPTSSSNSASPAPGSPATTPSAGAAAADPTPID 131
            ...:|.....|.|.  ...:|:..|..|||.:...|...:|.|...:|:...:....:|.|||
Zfish   172 ARMTVSGKKQTMGF--DVRSAEENGGVAPSLRRGPSPEATAVPTTETPSKQSTVTEDSAAPTP-- 232

  Fly   132 GLNPSDKIANNETDPADSWDVDDAVITPEDEEVEDAEFTEGEATPKVSKKKV---VKVEENRSKR 193
             ..||.|                                        ||:::   .::|:.:..:
Zfish   233 -TRPSGK----------------------------------------SKQQLNIRAELEKRQGGK 256

  Fly   194 EHVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRESWYLSWALDTNQEERDKG 258
            ..:|:|.||||||||||:.|.::.|.|.|:|||:.|||:||::..:.|:..:|.||...||||:|
Zfish   257 PLLNLVVIGHVDAGKSTLMGHLLYLLGNVNKRTMHKYEQEAKKAGKASFAYAWVLDETGEERDRG 321

  Fly   259 KTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQTRE 323
            .|::||...||||.|..|::||||||.|:||||.||||||:||||:.|.:||||.||:.||||||
Zfish   322 VTMDVGMTKFETDSKVVTLMDAPGHKDFIPNMITGAAQADVAVLVVDASRGEFEAGFEAGGQTRE 386

  Fly   324 HAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNPAKDLTFMPCSGLSGY 388
            ||:|.::.||..|.|.|||||.  |||.|.|:.|...|:..:||:.||..: |:.::|.|||||.
Zfish   387 HALLVRSLGVTQLAVAVNKMDQ--VNWQQERFQEIISKLGHFLKQAGFKDS-DVFYVPTSGLSGE 448

  Fly   389 GL--KDQIPETLCPWYRGPAFIPFIDELPSLNRKSDGPFIMPIVDKYKDMGT--VVMGKVESGTA 449
            .|  |.::.: |..||.||..:..||......|..:.||.:.:.|.:||.|:  .|.||:|:|..
Zfish   449 NLTTKSKVAD-LTAWYTGPCLVEQIDAFKPPQRSVEKPFRLCVSDVFKDQGSGFCVTGKIEAGYI 512

  Fly   450 RKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSPGFVLCDAANPIKTGK 514
            :.|..:|.||......|..:...|..:.....|::|.:.:.|::...::.|.|.||...||:...
Zfish   513 QTGDKVLAMPPNETCTVKGISLHDEALDWAAAGDHVSLTVTGMDIIKINVGCVFCDPKEPIRACT 577

  Fly   515 IFDAQVVILEHKSIICAGYSAVMHIHCAAEEVTVKALICLVDKKSGDKSKTRPRFVKQDQVAIMR 579
            .|.|::::...:..|..|:..::|....:|..|::.|:.::.|.||:..|.:|:.:.:.|.|::.
Zfish   578 RFRARILLFNIELPITQGFPVLLHYQTVSEPATIRKLVSVLHKSSGEVLKKKPKCLSKGQNAVVE 642

  Fly   580 IECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVVE 619
            |:....:.:|.:|.:.::|||.||....|||.|.|.::.|
Zfish   643 IQTQRPVAMELYKDYKELGRFMLRYVGSTIAAGVVTEIKE 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eRF3	NP_477259.1	PAM2	12..28	CDD:429316	4/15 (27%)
		EF1_alpha	197..416	CDD:206670	115/220 (52%)
		eRF3_II	424..505	CDD:293906	22/82 (27%)
		eRF3_C_III	511..617	CDD:294003	28/105 (27%)
hbs1l	NP_001295477.1	HBS1_N	<78..134	CDD:462642	6/26 (23%)
		PRK12323	<127..>259	CDD:481241	30/176 (17%)
		TEF1	256..682	CDD:444074	170/429 (40%)