DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eRF3 and Eef1a2

DIOPT Version :9

Sequence 1:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_036792.2	Gene:	Eef1a2 / 24799	RGDID:	3781	Length:	463	Species:	Rattus norvegicus

Alignment Length:	448	Identity:	169/448 - (37%)
Similarity:	259/448 - (57%)	Gaps:	29/448 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 KREHVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRESWYLSWALDTNQEERD 256
            ::.|:|:|.|||||:||||..|.::...|.:||||:||:|:||.|..:.|:..:|.||..:.||:
  Rat     4 EKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERE 68

  Fly   257 KGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQT 321
            :|.|:::....|||.:.:.||:|||||:.|:.|||.|.:|||.|||:::|..||||.|..:.|||
  Rat    69 RGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQT 133

  Fly   322 REHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNPAKDLTFMPCSGLS 386
            ||||:||.|.|||.|:|.|||||.....:.:.||:|...::..|:||:|:||| .:.|:|.||..
  Rat   134 REHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKKIGYNPA-TVPFVPISGWH 197

  Fly   387 GYGLKDQIPETLCPWYR------------GPAFIPFIDELPSLNRKSDGPFIMPIVDKYK--DMG 437
            |..:.:..|.  .||::            |.:.:..:|.:....|.:|.|..:|:.|.||  .:|
  Rat   198 GDNMLEPSPN--MPWFKGWKVERKEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIG 260

  Fly   438 TVVMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSPGFV 502
            ||.:|:||:|..|.|..:...|......|..:......::...||:||...:|.:..:|:..|.|
  Rat   261 TVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNV 325

  Fly   503 LCDA-ANPIKTGKIFDAQVVILEHKSIICAGYSAVM-----HIHCAAEEVTVKALICLVDKKSGD 561
            ..|: |:|.:....|.:||:||.|...|.||||.|:     ||.|...|:..|     :|::||.
  Rat   326 CGDSKADPPQEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEK-----IDRRSGK 385

  Fly   562 KSKTRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVVE 619
            |.:..|:.:|....||:.:.....:|:|.|..:|.:|||.:||..:|:|:| |:|.||
  Rat   386 KLEDNPKSLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVG-VIKNVE 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	167/446 (37%)
		EF1_alpha	197..416	CDD:206670	98/230 (43%)
		eRF3_II	424..505	CDD:293906	24/82 (29%)
		eRF3_C_III	511..617	CDD:294003	38/110 (35%)
Eef1a2	NP_036792.2	PTZ00141	1..460	CDD:185474	169/448 (38%)
		G1. /evidence=ECO:0000250	14..21		5/6 (83%)
		G2. /evidence=ECO:0000250	70..74		2/3 (67%)
		G3. /evidence=ECO:0000250	91..94		2/2 (100%)
		G4. /evidence=ECO:0000250	153..156		2/2 (100%)
		G5. /evidence=ECO:0000250	194..196		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..463
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X149
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820