DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eRF3 and erfa-3

DIOPT Version :9

Sequence 1:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001256292.1	Gene:	erfa-3 / 179537	WormBaseID:	WBGene00010405	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	530	Identity:	306/530 - (57%)
Similarity:	384/530 - (72%)	Gaps:	24/530 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 SSNSASPAPGSPATTPSAGAAAADPTPIDGLNPSDKIANNETDPAD-SWDVDDAVITPEDEEVED 166
            ::|:....||.| .||....||.:||       .|..|..:|.||. ..:|.:.|...|...|..
Worm    14 NANARPFVPGQP-YTPQPEQAAPEPT-------EDWEAQADTSPAAVQPEVAEPVAVQESAPVAP 70

  Fly   167 AEFTEG---EATPK------VSKK--KVVKVEENRSKREHVNVVFIGHVDAGKSTIGGQIMSLTG 220
            ...||.   |.||:      ::||  :.|.|::...| ||:|:||:|||||||||||||:|.|||
Worm    71 VSATEAPKKEPTPEEDLVAPLAKKFQRTVYVDDGTHK-EHINMVFVGHVDAGKSTIGGQLMFLTG 134

  Fly   221 MVDKRTLEKYEREAREKSRESWYLSWALDTNQEERDKGKTVEVGRAFFETDRKHFTILDAPGHKS 285
            ||||||||||||||:||.||||||||.:|||.|||:||||||||||:|||:::||||||||||||
Worm   135 MVDKRTLEKYEREAKEKGRESWYLSWCMDTNDEEREKGKTVEVGRAYFETEKRHFTILDAPGHKS 199

  Fly   286 FVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQTREHAMLAKTAGVKHLVVLVNKMDDPTVNW 350
            ||||||.||.||||||||||||:||||||||||||||||:||.|||||||||:||||||||||.|
Worm   200 FVPNMIVGANQADLAVLVISARRGEFETGFDRGGQTREHSMLVKTAGVKHLVILVNKMDDPTVKW 264

  Fly   351 DQTRYNECKDKILPYLKKLGFNPAKDLTFMPCSGLSGYGLKDQIPETLCPWYRGPAFIPFIDE-L 414
            ::.|:.|.:.|:.|:|:||||||..|:|::|||||:|..:||:...:...||.||.||.|||. |
Worm   265 EEERFKEIEGKLTPFLRKLGFNPKTDITYVPCSGLTGAFIKDRPTGSEGNWYSGPCFIEFIDVLL 329

  Fly   415 PSLNRKSDGPFIMPIVDKYKDMGTVVMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSV 479
            ||..|..:||....:.:||.:||||::||:|||..:||..|:||||:..|.|.|:::||.|...|
Worm   330 PSYKRDFNGPVRCTVAEKYSEMGTVIIGKMESGCVQKGDTLVVMPNKQPVQVLQIWADDVETERV 394

  Fly   480 GPGENVKIKLKGIEEEDVSPGFVLCDAANPIKTGKIFDAQVVILEHKSIICAGYSAVMHIHCAAE 544
            ..|:|:|.|||||||.::..||::|...:..|||::|||:|::|||:|||.:|||.|:||..|.|
Worm   395 VAGDNIKFKLKGIEENELQGGFIICSPDSLAKTGRVFDAEVLVLEHRSIIASGYSCVLHIQSAVE 459

  Fly   545 EVTVKALICLVDKKSGDKSKTRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTI 609
            |||||.:|..:|||:|:|.  |.:|||||:..|||:|......||.||.:|.:||||||||.|||
Worm   460 EVTVKGVIATIDKKTGEKK--RAKFVKQDEKCIMRLESPEPFVLEPFKEYPYLGRFTLRDEGKTI 522

  Fly   610 AIGKVLKVVE 619
            ||||||||||
Worm   523 AIGKVLKVVE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	276/428 (64%)
		EF1_alpha	197..416	CDD:206670	164/219 (75%)
		eRF3_II	424..505	CDD:293906	38/80 (48%)
		eRF3_C_III	511..617	CDD:294003	64/105 (61%)
erfa-3	NP_001256292.1	DUF959	24..>94	CDD:368758	21/77 (27%)
erfa-3	NP_001256292.1	TEF1	105..532	CDD:227581	276/429 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159094
Domainoid	1	1.000	337	1.000	Domainoid score	I591
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	583	1.000	Inparanoid score	I549
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54149
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	1	1.000	-	-		FOG0002347
OrthoInspector	1	1.000	-	-		oto18657
orthoMCL	1	0.900	-	-		OOG6_101550
Panther	1	1.100	-	-	LDO	PTHR23115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2104
SonicParanoid	1	1.000	-	-		X149
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.940