Protein Alignment eRF3 and hbs-1

DIOPT Version :10

• Sequence 1: NP_477259.1
• Gene: eRF3 / 34658
• FlyBaseID: FBgn0020443
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001021555.2
• Gene: hbs-1 / 172672
• WormBaseID: WBGene00010622
• Length: 610
• Species: Caenorhabditis elegans
• Alignment Length: 582
• Identity: 189/582 - (32%)
• Similarity: 291/582 - (50%)
• Gaps: 65/582 - (11%)

  Fly    73 SGGSTAGAAPPPPTAQGAGAAAPSAQPPTSSSNSASPAPGSPATTPSAGAAAADPT-PI--DGLN 134
            ||.::.....|.|     |..:.|..||.|     :|.|.:..||..:.....:.| |:  ....
 Worm    55 SGRNSPALPAPHP-----GIPSSSYHPPVS-----TPTPTAAPTTSLSSTIVRNMTAPLLHQNQK 109

  Fly   135 PSDKIANNETDPADSWDVDDAVITPEDEEVEDAEFTEGEATPKVSK------------------K 181
            |...:.:..:.|..|.:::....||:.:.:: ||.|    ||.||:                  .
 Worm   110 PPKNLNSRPSTPQTSSNLNTPKRTPQVKNLQ-AEST----TPTVSRPSSEVDLTSFRRNQLQNIA 169

  Fly   182 KVVKVEENRSK-----REHVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRES 241
            |...|.....|     ::.:|::.:|||||||||:.|.::....:||.||::|::.||....:.|
 Worm   170 KAPSVARKTPKPRVADKDLINLIVVGHVDAGKSTLMGHLLHDLEVVDSRTIDKFKHEAARNGKAS 234

  Fly   242 WYLSWALDTNQEERDKGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISA 306
            :..:|.||..:|||::|.|:::||..|||..:...:|||||||.|:.|||.|.:|||.|:||::|
 Worm   235 FAYAWVLDETEEERERGVTMDIGRTSFETSHRRIVLLDAPGHKDFISNMITGTSQADAAILVVNA 299

  Fly   307 RKGEFETGFDRGGQTREHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYL-KKLG 370
            ..|||||||:.||||:|||:|.::.||..|:|.|||:|  ||:|.|.|::|.|:.:..:| ::.|
 Worm   300 TTGEFETGFENGGQTKEHALLLRSLGVTQLIVAVNKLD--TVDWSQDRFDEIKNNLSVFLTRQAG 362

  Fly   371 FNPAKDLTFMPCSGLSGYGLKDQIPETLCPWYRGPAFIPFIDELPSLNRKSDGPFIMPIVD--KY 433
            |:..|   |:|.||.:|..|   |......||.||..:..||...:....||||..:.|.|  |.
 Worm   363 FSKPK---FVPVSGFTGENL---IKRMELDWYDGPCLLELIDSFVAPQPPSDGPLRIGISDVLKV 421

  Fly   434 KDMGTVVMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDD-----FEVTSVGPGENVKIKLKG-I 492
            .....||.||:|||...|...:.:|.:.|...|.:..::|     |      .|:.:.:.|:| .
 Worm   422 ASNQLVVSGKIESGEVEKDDKVYIMSSVTAATVKECANNDGSRHCF------AGDYILLTLQGTF 480

  Fly   493 EEEDVSPGFVLCDAA-NPIKTGKIFDAQVVILEHKSIICAGYSAVMHIHCAAEEVTVKALICLVD 556
            |.|.:..|.|:..|. :.:...|.|:.::|..|....|..|..|.::.|......|...|:..::
 Worm   481 EPESIQTGSVVVRAGPDTLIPSKKFEVRLVAFEIAMPIIKGAKAELYAHSLCVPCTFTNLLYTIN 545

  Fly   557 KKSGDKSKTRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVV 618
            |.:|:..|..|||:.:...|::.||....|.:|.|.....:||.|.|....|||.|.|.||:
 Worm   546 KSNGEILKKGPRFIAKGASAVVEIETEYDIAIETFTSCRALGRVTFRAGGNTIAAGIVEKVI 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eRF3	NP_477259.1	PAM2	12..28	CDD:429316
		EF1_alpha	197..416	CDD:206670	98/219 (45%)
		eRF3_II	424..505	CDD:293906	24/88 (27%)
		eRF3_C_III	511..617	CDD:294003	31/105 (30%)
hbs-1	NP_001021555.2	EF1_alpha	190..404	CDD:206670	98/221 (44%)
		Translation_Factor_II_like	410..491	CDD:445922	23/86 (27%)
		HBS1_C_III	502..606	CDD:294008	31/103 (30%)