DRSC/TRiP Functional Genomics Resources

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Protein Alignment eRF3 and HBS1L

DIOPT Version :10

Sequence 1:NP_477259.1 Gene:eRF3 / 34658 FlyBaseID:FBgn0020443 Length:619 Species:Drosophila melanogaster
Sequence 2:NP_006611.1 Gene:HBS1L / 10767 HGNCID:4834 Length:684 Species:Homo sapiens


Alignment Length:575 Identity:198/575 - (34%)
Similarity:302/575 - (52%) Gaps:50/575 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 SVGSGGSTAGAAPPPPTAQGAGAAAPSAQPPTSSSNS----------ASPAPGSPATTPSAGAAA 124
            :|.:|....|......|::......|.....|.|...          :|...|....||..|   
Human   135 TVSTGKIAKGKPVDSQTSRSESEIVPKVAKMTVSGKKQTMGFEVPGVSSEENGHSFHTPQKG--- 196

  Fly   125 ADPTPIDGLNPSD--KIANNETDPADSWDVDDAVITPEDEEVEDAEFTEGEATPKVSKKK----- 182
              |...|.:..||  :.|:...:|..:              ::.:|  |..:||...||.     
Human   197 --PPIEDAIASSDVLETASKSANPPHT--------------IQASE--EQSSTPAPVKKSGKLRQ 243

  Fly   183 ----VVKVEENRSKREHVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRESWY 243
                ..::|:.:..::.:|:|.||||||||||:.|.::.|.|.::|||:.|||:|:::..:.|:.
Human   244 QIDVKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFA 308

  Fly   244 LSWALDTNQEERDKGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARK 308
            .:|.||...|||::|.|::||...|||..|..|::||||||.|:||||.||||||:||||:.|.:
Human   309 YAWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASR 373

  Fly   309 GEFETGFDRGGQTREHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNP 373
            ||||.||:.|||||||.:|.::.||..|.|.|||||.  |||.|.|:.|...|:..:||:.||..
Human   374 GEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQ--VNWQQERFQEITGKLGHFLKQAGFKE 436

  Fly   374 AKDLTFMPCSGLSGYGL--KDQIPETLCPWYRGPAFIPFIDELPSLNRKSDGPFIMPIVDKYKDM 436
            : |:.|:|.|||||..|  :.|..| |..||:|...:..||......|..|.||.:.:.|.:||.
Human   437 S-DVGFIPTSGLSGENLITRSQSSE-LTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQ 499

  Fly   437 GT--VVMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSP 499
            |:  .:.||:|:|..:.|..||.||......|..:...|..|.....|::|.:.|.|::...::.
Human   500 GSGFCITGKIEAGYIQTGDRLLAMPPNETCTVKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINV 564

  Fly   500 GFVLCDAANPIKTGKIFDAQVVILEHKSIICAGYSAVMHIHCAAEEVTVKALICLVDKKSGDKSK 564
            |.:.|....|||....|.|:::|...:..|..|:..::|....:|...:|.||.:::|.:|:.:|
Human   565 GCIFCGPKVPIKACTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTK 629

  Fly   565 TRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVVE 619
            .:|:|:.:.|.|::.::....|.||.:|.|.::|||.||....|||.|.|.::.|
Human   630 KKPKFLTKGQNALVELQTQRPIALELYKDFKELGRFMLRYGGSTIAAGVVTEIKE 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eRF3NP_477259.1 PAM2 12..28 CDD:429316
EF1_alpha 197..416 CDD:206670 111/220 (50%)
eRF3_II 424..505 CDD:293906 23/82 (28%)
eRF3_C_III 511..617 CDD:294003 33/105 (31%)
HBS1LNP_006611.1 HBS1_N 54..129 CDD:462642
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 170..241 17/91 (19%)
TEF1 261..684 CDD:444074 172/426 (40%)
G1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 267..274 6/6 (100%)
G2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 323..327 2/3 (67%)
G3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 344..347 2/2 (100%)
G4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 406..409 2/2 (100%)
G5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01059 445..447 1/1 (100%)
Interaction with the exosome complex. /evidence=ECO:0000269|PubMed:28204585 546..572 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

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