DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eRF3 and HBS1L

DIOPT Version :9

Sequence 1:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_006611.1	Gene:	HBS1L / 10767	HGNCID:	4834	Length:	684	Species:	Homo sapiens

Alignment Length:	575	Identity:	198/575 - (34%)
Similarity:	302/575 - (52%)	Gaps:	50/575 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SVGSGGSTAGAAPPPPTAQGAGAAAPSAQPPTSSSNS----------ASPAPGSPATTPSAGAAA 124
            :|.:|....|......|::......|.....|.|...          :|...|....||..|
Human   135 TVSTGKIAKGKPVDSQTSRSESEIVPKVAKMTVSGKKQTMGFEVPGVSSEENGHSFHTPQKG--- 196

  Fly   125 ADPTPIDGLNPSD--KIANNETDPADSWDVDDAVITPEDEEVEDAEFTEGEATPKVSKKK----- 182
              |...|.:..||  :.|:...:|..:              ::.:|  |..:||...||.
Human   197 --PPIEDAIASSDVLETASKSANPPHT--------------IQASE--EQSSTPAPVKKSGKLRQ 243

  Fly   183 ----VVKVEENRSKREHVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRESWY 243
                ..::|:.:..::.:|:|.||||||||||:.|.::.|.|.::|||:.|||:|:::..:.|:.
Human   244 QIDVKAELEKRQGGKQLLNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFA 308

  Fly   244 LSWALDTNQEERDKGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARK 308
            .:|.||...|||::|.|::||...|||..|..|::||||||.|:||||.||||||:||||:.|.:
Human   309 YAWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGAAQADVAVLVVDASR 373

  Fly   309 GEFETGFDRGGQTREHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNP 373
            ||||.||:.|||||||.:|.::.||..|.|.|||||.  |||.|.|:.|...|:..:||:.||..
Human   374 GEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMDQ--VNWQQERFQEITGKLGHFLKQAGFKE 436

  Fly   374 AKDLTFMPCSGLSGYGL--KDQIPETLCPWYRGPAFIPFIDELPSLNRKSDGPFIMPIVDKYKDM 436
            : |:.|:|.|||||..|  :.|..| |..||:|...:..||......|..|.||.:.:.|.:||.
Human   437 S-DVGFIPTSGLSGENLITRSQSSE-LTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQ 499

  Fly   437 GT--VVMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSP 499
            |:  .:.||:|:|..:.|..||.||......|..:...|..|.....|::|.:.|.|::...::.
Human   500 GSGFCITGKIEAGYIQTGDRLLAMPPNETCTVKGITLHDEPVDWAAAGDHVSLTLVGMDIIKINV 564

  Fly   500 GFVLCDAANPIKTGKIFDAQVVILEHKSIICAGYSAVMHIHCAAEEVTVKALICLVDKKSGDKSK 564
            |.:.|....|||....|.|:::|...:..|..|:..::|....:|...:|.||.:::|.:|:.:|
Human   565 GCIFCGPKVPIKACTRFRARILIFNIEIPITKGFPVLLHYQTVSEPAVIKRLISVLNKSTGEVTK 629

  Fly   565 TRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVVE 619
            .:|:|:.:.|.|::.::....|.||.:|.|.::|||.||....|||.|.|.::.|
Human   630 KKPKFLTKGQNALVELQTQRPIALELYKDFKELGRFMLRYGGSTIAAGVVTEIKE 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	172/431 (40%)
		EF1_alpha	197..416	CDD:206670	111/220 (50%)
		eRF3_II	424..505	CDD:293906	23/82 (28%)
		eRF3_C_III	511..617	CDD:294003	33/105 (31%)
HBS1L	NP_006611.1	HBS1_N	54..129	CDD:312481
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..241		17/91 (19%)
		TEF1	256..684	CDD:227581	172/431 (40%)
		G1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	267..274		6/6 (100%)
		G2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	323..327		2/3 (67%)
		G3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	344..347		2/2 (100%)
		G4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	406..409		2/2 (100%)
		G5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01059	445..447		1/1 (100%)
		Interaction with the exosome complex. /evidence=ECO:0000269\|PubMed:28204585	546..572		6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5256
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820