DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eRF3 and hbs1l

DIOPT Version :9

Sequence 1:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_012818243.1	Gene:	hbs1l / 100170572	XenbaseID:	XB-GENE-944105	Length:	677	Species:	Xenopus tropicalis

Alignment Length:	527	Identity:	195/527 - (37%)
Similarity:	293/527 - (55%)	Gaps:	34/527 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 PPTSSSNSASPAPGSPATTPSAGAAAADPTPIDGLNPSDKIANNETDPADSWDVDDAVITPEDEE 163
            |..||..:.....|.   |.......||    :||..::.|.:::.....|     :::||
Frog   179 PSVSSEINGQSVKGQ---TNEEAMEEAD----NGLQSANPIPSSQNTEEHS-----SIMTP---- 227

  Fly   164 VEDAEFTEGEATPKVSKKKVVKVE-ENRSKREH-VNVVFIGHVDAGKSTIGGQIMSLTGMVDKRT 226
                    |:::.|..:|..:|.| |.|...:| :|:|.||||||||||:.|.::.|.|.|:|||
Frog   228 --------GKSSNKAKQKINIKEELEKRQGGKHLLNLVVIGHVDAGKSTLMGHLLYLLGHVNKRT 284

  Fly   227 LEKYEREAREKSRESWYLSWALDTNQEERDKGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMI 291
            :.|||:|:::..:.|:..:|.||...|||.:|.|::||...|||..|..|::||||||.|:||||
Frog   285 MHKYEQESKKAGKASFAYAWVLDETGEERQRGVTMDVGMTKFETKSKVITLMDAPGHKDFIPNMI 349

  Fly   292 GGAAQADLAVLVISARKGEFETGFDRGGQTREHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYN 356
            .||||||:|||.:.|.:||||.||:.||||||||:|.::.||..|.|.|||||.  |||.|.|:|
Frog   350 TGAAQADVAVLAVDASRGEFEAGFEAGGQTREHALLVRSLGVTQLAVAVNKMDQ--VNWQQERFN 412

  Fly   357 ECKDKILPYLKKLGFNPAKDLTFMPCSGLSGYGL--KDQIPETLCPWYRGPAFIPFIDELPSLNR 419
            |...|:..:||:.||..: |:.::|.|||||..|  :.||.| |..||:||..:..||...:..|
Frog   413 EVTSKLGHFLKQAGFKES-DVYYIPTSGLSGENLVKRSQISE-LINWYKGPCLLEQIDYFKAPQR 475

  Fly   420 KSDGPFIMPIVDKYKDMGT--VVMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPG 482
            ..|.||.:...|.:||.|:  .|.||:|:|..:.|..||.||......|..:...:..|.....|
Frog   476 SVDKPFRLCTSDVFKDQGSGFCVTGKIEAGFVQTGDRLLAMPPHETCTVKGITLHEEAVDWAAAG 540

  Fly   483 ENVKIKLKGIEEEDVSPGFVLCDAANPIKTGKIFDAQVVILEHKSIICAGYSAVMHIHCAAEEVT 547
            ::|.:.|.|::...::.|.|.|....|||....|.|:|:|...:..|..|:..::|....:|..|
Frog   541 DHVSLTLTGMDIIKINVGCVFCSPNEPIKACTRFRARVLIFNFEVPITQGFPVLIHYQTVSEPAT 605

  Fly   548 VKALICLVDKKSGDKSKTRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIG 612
            ::.|:.::.|.:|:..|.:|:.:.:...|::.::....|.||.:|.|.::|||.||....:||.|
Frog   606 IRKLVSVLHKSTGEVMKKKPKCLTKGMNAVIELQTQRPIALELYKDFKELGRFMLRYSGSSIAAG 670

  Fly   613 KVLKVVE 619
            .|.::.|
Frog   671 VVTEIKE 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	174/432 (40%)
		EF1_alpha	197..416	CDD:206670	114/220 (52%)
		eRF3_II	424..505	CDD:293906	24/82 (29%)
		eRF3_C_III	511..617	CDD:294003	30/105 (29%)
hbs1l	XP_012818243.1	HBS1_N	<69..118	CDD:370196
hbs1l	XP_012818243.1	TEF1	254..677	CDD:227581	173/426 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920