DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eRF3 and eef1a1b

DIOPT Version :9

Sequence 1:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001017795.1	Gene:	eef1a1b / 100004503	ZFINID:	ZDB-GENE-050417-327	Length:	462	Species:	Danio rerio

Alignment Length:	445	Identity:	168/445 - (37%)
Similarity:	254/445 - (57%)	Gaps:	29/445 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 HVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRESWYLSWALDTNQEERDKGK 259
            |:|:|.|||||:||||..|.::...|.:||||:||:|:||.|..:.|:..:|.||..:.||::|.
Zfish     7 HINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGI 71

  Fly   260 TVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQTREH 324
            |:::....|||.:.:.||:|||||:.|:.|||.|.:|||.|||:::|..||||.|..:.||||||
Zfish    72 TIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREH 136

  Fly   325 AMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNPAKDLTFMPCSGLSGYG 389
            |:||.|.|||.|:|.|||||....|:.|.||.|...::..|:||:|:|| ..:.|:|.||.:|..
Zfish   137 ALLAYTLGVKQLIVGVNKMDSTEPNYSQKRYEEIVKEVSTYIKKIGYNP-DTVAFVPISGWNGDN 200

  Fly   390 LKDQIPETLCPWYR------------GPAFIPFIDELPSLNRKSDGPFIMPIVDKYK--DMGTVV 440
            :.:..|.  ..|::            |...:..:|.:....|.:|.|..:|:.|.||  .:|||.
Zfish   201 MLEASPN--MTWFKGWKITRKDGSSSGTTLLEALDAIQPPTRPTDKPLRLPLQDVYKIGGIGTVP 263

  Fly   441 MGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSPGFVLCD 505
            :|:||:|..:.|..:...|......|..:......::...||:||...:|.:..:|:..|.|..|
Zfish   264 VGRVETGILKPGLVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVAGD 328

  Fly   506 AAN-PIKTGKIFDAQVVILEHKSIICAGYSAVM-----HIHCAAEEVTVKALICLVDKKSGDKSK 564
            :.| |.:....|.|||:||.|...|.|||:.|:     ||.|...|:..|     :|::||.|.:
Zfish   329 SKNDPPQEAASFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEK-----IDRRSGKKLE 388

  Fly   565 TRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVVE 619
            ..|:.:|....||:.:.....:|:|.|..:|.:|||.:||..:|:|:| |:|.||
Zfish   389 DNPKSLKSGDAAIVDMIPGKPMCVESFSEYPPLGRFAVRDMRQTVAVG-VIKGVE 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	166/443 (37%)
		EF1_alpha	197..416	CDD:206670	98/230 (43%)
		eRF3_II	424..505	CDD:293906	23/82 (28%)
		eRF3_C_III	511..617	CDD:294003	38/110 (35%)
eef1a1b	NP_001017795.1	PTZ00141	1..460	CDD:185474	168/445 (38%)
		EF1_alpha	9..238	CDD:206670	98/231 (42%)
		EF1_alpha_II	242..332	CDD:293894	25/89 (28%)
		EF1_alpha_III	336..438	CDD:294004	37/107 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010