DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6388 and Trmt1l

DIOPT Version :9

Sequence 1:	NP_609566.1	Gene:	CG6388 / 34656	FlyBaseID:	FBgn0032430	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_081152.2	Gene:	Trmt1l / 98685	MGIID:	1916185	Length:	728	Species:	Mus musculus

Alignment Length:	540	Identity:	115/540 - (21%)
Similarity:	205/540 - (37%)	Gaps:	149/540 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EEKPQII----AENPNENVIRERNAEIVSGGNV--------FYNPVQEFNRDLSIAALNVYRQRL 57
            |.|.:.|    |::.|| :::|.:.:|....|.        ::||..:.||.:....|
Mouse   208 ETKSRYIAASTAKSSNE-ILKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTL------- 264

  Fly    58 TKERSEKALKKQRKKVKEQEDEKTTPVPEDPPVYEAGTRYEDGLRILEALAATGLRSIRYAQEIA 122
                  .||.|:||.                            |..|:|..|||:..:::|:.:.
Mouse   265 ------AALAKERKP----------------------------LECLDAFGATGIMGLQWAKHLG 295

  Fly   123 GVRQIVANDLSRQAVASINTNIRHNKVEEL--------------------IEPSHSDAMTLMYLS 167
            ...::..|||:..:|..|..|...||::.:                    |:.:..||..||:|
Mouse   296 NAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEGDALEDDGTLGDIQVTRMDANVLMHL- 359

  Fly   168 TQPEKRFDAVDLDPYGCPNRFLDGAMQCLVDGGLLLVTATDMAVLAGNAPEACYVKYGSVPLRMK 232
                :.||.:.|||:|....:||.|.:.:.:.|::.||:||::.|...|.......||...:|.:
Mouse   360 ----RSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTE 420

  Fly   233 CCHEMALRILLHCIESHANRYGKYIEPLLSISADFYIRIFVRVYVGQAQCKLSMSKQSWIYQCTG 297
            ...|:|.||::..:...|.|..|.||.|.:::.:.::.:.|||..|......:..|..::..|..
Mouse   421 YYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQW 485

  Fly   298 CETFTLQPLG-ITKPNPTAGNPQQLKFGIPTGPAVNSQCEHCGHRHHLGGPIWSAPIHNPEFVQD 361
            ||....|..| :.:.||....|......:|...|:..            ||:||:.:.|..|::.
Mouse   486 CEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIEL------------GPLWSSSLFNTGFLKR 538

  Fly   362 LL-------------------------------------TAVQE-----------TTL---QSLG 375
            :|                                     |..||           ||:   .:.|
Mouse   539 MLFESIHHGLDDIQPLIKTLIFESECTPQSQCSTHAPSNTNKQEENGVFVKTTDDTTIDIYSAQG 603

  Fly   376 TQRRIVGVLSMVQEELQDV-----PLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSYSHASK 435
            .::.....:::.:::..|.     |.||...: ..:..:.:..:.||...:..||:|||.:|...
Mouse   604 KRKSNEMAINLAKKQKTDASTAHPPFYYNIHR-HSIKGMNMPKLKKFLCCLSQAGFRVSRTHFDP 667

  Fly   436 NSLKTNAPPAVLWDILRSWS 455
            ..::|:||......||..:|
Mouse   668 MGIRTDAPLMQFKSILLKYS 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6388	NP_609566.1	AdoMet_MTases	17..452	CDD:302624	108/519 (21%)
CG6388	NP_609566.1	DUF1764	<58..>103	CDD:285744	6/44 (14%)
Trmt1l	NP_081152.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..118
		PHD_SF	<157..202	CDD:304600
		AdoMet_MTases	225..687	CDD:302624	108/520 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..728
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1414511at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10631
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920