DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6388 and TRMT1L

DIOPT Version :9

Sequence 1:	NP_609566.1	Gene:	CG6388 / 34656	FlyBaseID:	FBgn0032430	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_112196.3	Gene:	TRMT1L / 81627	HGNCID:	16782	Length:	733	Species:	Homo sapiens

Alignment Length:	545	Identity:	114/545 - (20%)
Similarity:	204/545 - (37%)	Gaps:	149/545 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVDEEKPQIIAEN---PNENVIRERNAEIVSGGNV--------FYNPVQEFNRDLSIAALNVYR 54
            |...|.|...||.:   |.:.:::|.:.::....|.        ::||..:.||.|....|
Human   207 MNKGETKSSYIAASTAKPPKEILKEADTDVQVCPNYSIPQKTDSYFNPKMKLNRQLIFCTL---- 267

  Fly    55 QRLTKERSEKALKKQRKKVKEQEDEKTTPVPEDPPVYEAGTRYEDGLRILEALAATGLRSIRYAQ 119
                     .||.::||.                            |..|:|..|||:..:::|:
Human   268 ---------AALAEERKP----------------------------LECLDAFGATGIMGLQWAK 295

  Fly   120 EIAGVRQIVANDLSRQAVASINTNIRHNKVEELIEPSHS----------------------DAMT 162
            .:....::..|||:..:|..|..|...||::.:::....                      ||..
Human   296 HLGNAVKVTINDLNENSVTLIQENCHLNKLKVVVDSKEKEKSDDILEEGEKNLGNIKVTKMDANV 360

  Fly   163 LMYLSTQPEKRFDAVDLDPYGCPNRFLDGAMQCLVDGGLLLVTATDMAVLAGNAPEACYVKYGSV 227
            ||:|     :.||.:.|||:|....:||.|.:.:.:.|::.||:||::.|...|.......||..
Human   361 LMHL-----RSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKAQHVARRHYGCN 420

  Fly   228 PLRMKCCHEMALRILLHCIESHANRYGKYIEPLLSISADFYIRIFVRVYVGQAQCKLSMSKQSWI 292
            .:|.:...|:|.||::..:...|.|..|.||.|.:::.:.::.:.|||..|......:..|..::
Human   421 IVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYL 485

  Fly   293 YQCTGCETFTLQPLG-ITKPNPTAGNPQQLKFGIPTGPAVNSQCEHCGHRHHLGGPIWSAPIHNP 356
            ..|..||....|..| :.:.||....|......:|...|:..            ||:||:.:.|.
Human   486 IHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIEL------------GPLWSSSLFNT 538

  Fly   357 EFVQ------------DLLTAVQ------ETTLQS------------------------------ 373
            .|::            |:.|.::      |.|.||
Human   539 GFLKRMLFESLHHGLDDIQTLIKTLIFESECTPQSQFSIHASSNVNKQEENGVFIKTTDDTTTDN 603

  Fly   374 ---LGTQRRIVGVLSMVQEELQDV-----PLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSY 430
               .|.::....:.::.:::..||     |.||...: ..:..:.:..:.||...:..||:|||.
Human   604 YIAQGKRKSNEMITNLGKKQKTDVSTEHPPFYYNIHR-HSIKGMNMPKLKKFLCYLSQAGFRVSR 667

  Fly   431 SHASKNSLKTNAPPAVLWDILRSWS 455
            :|.....::|:||......||..:|
Human   668 THFDPMGVRTDAPLMQFKSILLKYS 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6388	NP_609566.1	AdoMet_MTases	17..452	CDD:302624	106/521 (20%)
CG6388	NP_609566.1	DUF1764	<58..>103	CDD:285744	5/44 (11%)
TRMT1L	NP_112196.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
TRMT1L	NP_112196.3	AdoMet_MTases	251..692	CDD:327401	105/499 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1414511at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10631
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920