DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6388 and trmt1

DIOPT Version :9

Sequence 1:	NP_609566.1	Gene:	CG6388 / 34656	FlyBaseID:	FBgn0032430	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	XP_004919201.1	Gene:	trmt1 / 779562	XenbaseID:	XB-GENE-994762	Length:	625	Species:	Xenopus tropicalis

Alignment Length:	575	Identity:	273/575 - (47%)
Similarity:	351/575 - (61%)	Gaps:	40/575 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ENPNENVIRERNAEIV--SGGNVFYNPVQEFNRDLSIAALNVY-RQRLTKERSEKALKKQRKKVK 74
            |:..|..|.|..|.::  |...|||||||||||||:.|.:..: |..|.::.::..:..:|.:.|
Frog    38 ESSGETFIHEGKASVIFPSANQVFYNPVQEFNRDLTCAVITEFSRLHLQQKGTDIVVPGERVEQK 102

  Fly    75 ------EQEDEKTTPVPE------DPPVYEAGTRYEDGLRILEALAATGLRSIRYAQEIAGVRQI 127
                  |..::|.|..||      |.|....|....|||||||.|||:||||||:|:|:.|:..:
Frog   103 LVVNLSETGEDKVTSSPENNSTPPDRPTAHVGEPCPDGLRILEGLAASGLRSIRFAREVPGLHSV 167

  Fly   128 VANDLSRQAVASINTNIRHNKVEELIEPSHSDAMTLMYLSTQPEKRFDAVDLDPYGCPNRFLDGA 192
            ||||.|..||..|..||:||.|..|:..|:.||..:||..|..:.|||.:||||||.|:.|||.|
Frog   168 VANDFSASAVELIKRNIQHNDVGNLVTGSYGDARMVMYNRTGAKDRFDVIDLDPYGSPSMFLDAA 232

  Fly   193 MQCLVDGGLLLVTATDMAVLAGNAPEACYVKYGSVPLRMKCCHEMALRILLHCIESHANRYGKYI 257
            :|.:.:||||.:|.|||||||||..|.||.|||::.::.|.|||||||||||.::..||.|.:||
Frog   233 VQSVSEGGLLCITCTDMAVLAGNNGETCYSKYGAMSIKSKFCHEMALRILLHSLDLRANCYQRYI 297

  Fly   258 EPLLSISADFYIRIFVRVYVGQAQCKLSMSKQSWIYQCTGCETFTLQPLGITKPNPTAGNPQQLK 322
            .|||.||.|||||:||||:.|||:.|:..|||:.:|.|.||.|:.||.||   ...|.||  .:|
Frog   298 VPLLCISVDFYIRVFVRVFTGQAKVKMCASKQALLYNCVGCGTYHLQRLG---KATTHGN--NMK 357

  Fly   323 FGIPTGPAVNSQCEHCGHRHHLGGPIWSAPIHNPEFVQDLLTAVQETTLQSLGTQRRIVGVLSMV 387
            :...|||.|.:.||.|..||.||||||:..:|:.:||:.:|:|: |...:...|..||.||||||
Frog   358 YSPATGPPVTASCEFCHQRHQLGGPIWAESLHDKDFVERILSAL-ERNPKRFKTSERIQGVLSMV 421

  Fly   388 QEELQDVPLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSYSHASKNSLKTNAPPAVLWDILR 452
            .|||.|||||||.|.|..|::.....:|:||||:||||||||.|||.||:|||:|||:|:|||:|
Frog   422 TEELSDVPLYYTLDNLSSVIRCNTPSLLQFRSALLHAGYRVSLSHACKNALKTDAPPSVIWDIMR 486

  Fly   453 SWSKRHPVNPERMIPGSPLAAILSKECTAVYEFDELHPEANPKSRKSALSRFQENPTPHWGPGTR 517
            .|.|::||..||:....|...|||||......| |:..:|||||||..|.||||||..:|||..|
Frog   487 CWEKQNPVKRERLSETCPAFHILSKEPKIEGSF-EIREDANPKSRKMGLKRFQENPEANWGPKAR 550

  Fly   518 ATIMIGDNKLPKSYRNQNKKQRHKASEQQAEDDQQDTPQAVDEYDGDVEHLPKQP 572
            |....|.....:..|.|::.:|..|            |.|      |..||...|
Frog   551 AKAGGGIATTLEDKRKQHQNKRKNA------------PSA------DESHLKSFP 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6388	NP_609566.1	AdoMet_MTases	17..452	CDD:302624	227/449 (51%)
CG6388	NP_609566.1	DUF1764	<58..>103	CDD:285744	13/56 (23%)
trmt1	XP_004919201.1	TRM	41..486	CDD:396545	227/450 (50%)
trmt1	XP_004919201.1	ZnF_C3H1	584..608	CDD:214632	1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	421	1.000	Domainoid score	I632
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5632
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1407
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1414511at2759
OrthoFinder	1	1.000	-	-		FOG0003425
OrthoInspector	1	1.000	-	-		oto103127
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060