Protein Alignment Trm1 and TRMT1

DIOPT Version :10

• Sequence 1: NP_609566.1
• Gene: Trm1 / 34656
• FlyBaseID: FBgn0032430
• Length: 578
• Species: Drosophila melanogaster
• Sequence 2: NP_060192.1
• Gene: TRMT1 / 55621
• HGNCID: 25980
• Length: 659
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 262/607 - (43%)
• Similarity: 351/607 - (57%)
• Gaps: 50/607 - (8%)

  Fly     5 EEKPQIIAENPNENVIRERNAEIV--SGGNVFYNPVQEFNRDLSIAALNVY-RQRL------TKE 60
            ||:|:.:    .|..:.|..|:|.  |...|||||||||||||:.|.:..: |.:|      .|.
Human    46 EERPREV----QETTVTEGAAKIAFPSANEVFYNPVQEFNRDLTCAVITEFARIQLGAKGIQIKV 106

  Fly    61 RSEKALKKQRKKVKEQEDEK-------TTPVPEDPPVYEAGTRYEDGLRILEALAATGLRSIRYA 118
            ..||..:|....:.|||:||       .....:.|.....|...|:||.:||.|||:||||||:|
Human   107 PGEKDTQKVVVDLSEQEEEKVELKESENLASGDQPRTAAVGEICEEGLHVLEGLAASGLRSIRFA 171

  Fly   119 QEIAGVRQIVANDLSRQAVASINTNIRHNKVEELIEPSHSDAMTLMYLSTQPEKRFDAVDLDPYG 183
            .|:.|:|.:||||.|.:||..|..|::.|.|..|::||.:||..|||...:..:|||.:||||||
Human   172 LEVPGLRSVVANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYQHQRVSERFDVIDLDPYG 236

  Fly   184 CPNRFLDGAMQCLVDGGLLLVTATDMAVLAGNAPEACYVKYGSVPLRMKCCHEMALRILLHCIES 248
            .|..|||.|:|.:.:||||.||.|||||||||:.|.||.|||::.|:.:.||||||||:||.::.
Human   237 SPATFLDAAVQAVSEGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDL 301

  Fly   249 HANRYGKYIEPLLSISADFYIRIFVRVYVGQAQCKLSMSKQSWIYQCTGCETFTLQPLGITKPNP 313
            .||.|.:::.||||||||||:|:||||:.|||:.|.|.|||:.::||.||..|.||.||.....|
Human   302 RANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCGAFHLQRLGKASGVP 366

  Fly   314 TAGNPQQLKFGIPTGPAVNSQCEHCGHRHHLGGPIWSAPIHNPEFVQDLLTAVQETTLQSLGTQR 378
            :.    :.||....||.|..:|||||.||.||||:|:.|||:.:||..:|.||.... ....|..
Human   367 SG----RAKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANP-GRFHTSE 426

  Fly   379 RIVGVLSMVQEELQDVPLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSYSHASKNSLKTNAP 443
            ||.||||::.|||.|||||||.|:|...:......:|:.|||:|||.:|||.|||.||::||:||
Human   427 RIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAP 491

  Fly   444 PAVLWDILRSWSKRHPVNPERMIPGSPLAAILSKECTAVYEFDELHPEANPKSRKSALSRFQENP 508
            .:.||||:|.|.|..||..||:...||...|||.|......| .:..:|||.||:..|.|||.||
Human   492 ASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANF-TIREDANPSSRQRGLKRFQANP 555

  Fly   509 TPHWGPGTRATIMIGDNKLPKSYRNQNKKQRHKASEQQAEDDQQDTPQAVDEYD----------- 562
            ..:|||..||       :......::..::|.:..:.:.::..:|..|......
Human   556 EANWGPRPRA-------RPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKEGT 613

  Fly   563 ---GD---VEHLPKQPKLEATA 578
               ||   ..|.|..|::.|.|
Human   614 CQRGDQCCYSHSPPTPRVSADA 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trm1	NP_609566.1	AdoMet_MTases	17..452	CDD:473071	219/450 (49%)
TRMT1	NP_060192.1	TRM	45..500	CDD:396545	222/462 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	537..578		16/47 (34%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:28784718	543..575		13/38 (34%)
		ZnF_C3H1	600..626	CDD:214632	3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..659		7/20 (35%)