DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6388 and Trmt1

DIOPT Version :9

Sequence 1:	NP_609566.1	Gene:	CG6388 / 34656	FlyBaseID:	FBgn0032430	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_001013892.2	Gene:	Trmt1 / 288914	RGDID:	1305992	Length:	663	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	266/565 - (47%)
Similarity:	347/565 - (61%)	Gaps:	33/565 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EEKPQIIAENPNENV--IRERNAEI--VSGGNVFYNPVQEFNRDLSIAALNVY-RQRL------T 58
            ||:|      |...|  :.|..|.|  .|...|||||||||||||:.|.:..: |..|      .
  Rat    47 EERP------PAAPVATVTEGAARISFPSANEVFYNPVQEFNRDLTCAVITEFARIHLGAKGIQI 105

  Fly    59 KERSEKALKKQRKKVKEQEDE----KTTPVPEDPPVYEA-GTRYEDGLRILEALAATGLRSIRYA 118
            |...||.|:|....:.:||:|    .....|.|.|...| |...::|||:||.|||:||||||:|
  Rat   106 KVPGEKDLQKIAVDLSDQEEETAGQNENLAPGDQPRTAAVGEICQEGLRVLEGLAASGLRSIRFA 170

  Fly   119 QEIAGVRQIVANDLSRQAVASINTNIRHNKVEELIEPSHSDAMTLMYLSTQPEKRFDAVDLDPYG 183
            .|:.|::.:||||.|.:||..::.|:..|.|..|::|:.:||..|||...:..:|||.:||||||
  Rat   171 LEVPGLQSVVANDASARAVELMHRNVELNGVAHLVQPNQADARMLMYQHQKASERFDVIDLDPYG 235

  Fly   184 CPNRFLDGAMQCLVDGGLLLVTATDMAVLAGNAPEACYVKYGSVPLRMKCCHEMALRILLHCIES 248
            .|..|||.|:|.:.|||||.||.|||||||||:.|.||.|||::.|:.:.||||||||:||.::.
  Rat   236 SPAPFLDAAVQAVSDGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDL 300

  Fly   249 HANRYGKYIEPLLSISADFYIRIFVRVYVGQAQCKLSMSKQSWIYQCTGCETFTLQPLGITKPNP 313
            |||.|.:||.||||||||||:|:||||:.|||:.|.|.|||:.::||.||..|.||.||     .
  Rat   301 HANCYQRYIVPLLSISADFYVRVFVRVFTGQAKVKSSASKQALVFQCVGCGAFYLQRLG-----K 360

  Fly   314 TAGNP-QQLKFGIPTGPAVNSQCEHCGHRHHLGGPIWSAPIHNPEFVQDLLTAVQETTLQSLGTQ 377
            .:|:| .::||....||.|:.:|||||.||.||||:|:.|||:.:||..:|.|| .|......|.
  Rat   361 ASGDPGGRVKFSAACGPPVSPECEHCGQRHQLGGPMWAEPIHDLDFVGQVLEAV-TTNPGRFHTS 424

  Fly   378 RRIVGVLSMVQEELQDVPLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSYSHASKNSLKTNA 442
            .||.||||:|.|||.|||||||.|:|...:......:|:.|||:||||:|||.|||.||::||:|
  Rat   425 TRIQGVLSVVTEELPDVPLYYTLDQLSSTVHCNTPRLLQLRSALLHAGFRVSLSHACKNAVKTDA 489

  Fly   443 PPAVLWDILRSWSKRHPVNPERMIPGSPLAAILSKECTAVYEFDELHPEANPKSRKSALSRFQEN 507
            .|..||||:|.|.|..||..||:...||...||:.|......|: :..:|||.||:..|.|||.|
  Rat   490 SPEALWDIMRCWEKECPVKRERLSESSPAFRILAVEPRLKANFN-IREDANPSSRQRGLKRFQAN 553

  Fly   508 PTPHWGPGTRATIMIGDNKLPKSYRNQNKKQRHKASEQQAEDDQQ 552
            |..:|||..||  ..|.....:....:.:..::|..| .|||..|
  Rat   554 PEANWGPRPRA--RPGGKAASEGLAERRRLLQNKRKE-PAEDPAQ 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6388	NP_609566.1	AdoMet_MTases	17..452	CDD:302624	226/451 (50%)
CG6388	NP_609566.1	DUF1764	<58..>103	CDD:285744	15/49 (31%)
Trmt1	NP_001013892.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341869
Domainoid	1	1.000	414	1.000	Domainoid score	I648
eggNOG	1	0.900	-	-		E1_COG1867
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5632
Inparanoid	1	1.050	461	1.000	Inparanoid score	I1495
OMA	1	1.010	-	-		QHG54291
OrthoDB	1	1.010	-	-		D1414511at2759
OrthoFinder	1	1.000	-	-		FOG0003425
OrthoInspector	1	1.000	-	-		oto96414
orthoMCL	1	0.900	-	-		OOG6_101071
Panther	1	1.100	-	-	LDO	PTHR10631
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2318
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770