DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6388 and trm1

DIOPT Version :9

Sequence 1:	NP_609566.1	Gene:	CG6388 / 34656	FlyBaseID:	FBgn0032430	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_596547.1	Gene:	trm1 / 2540604	PomBaseID:	SPBC25D12.05	Length:	548	Species:	Schizosaccharomyces pombe

Alignment Length:	540	Identity:	222/540 - (41%)
Similarity:	313/540 - (57%)	Gaps:	62/540 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NPNENVIRERNAEIVSGGNVFYNPVQEFNRDLSIAALNVYRQRLTKERSEKALKK---------Q 69
            ||||               |||||||:||||||:.|:..:    ::.||:|.:.|         |
pombe    43 NPNE---------------VFYNPVQQFNRDLSVTAIRAW----SETRSKKIVAKSHHRHQLLDQ 88

  Fly    70 RKKVKEQE--------------DEKTTPVPEDPPVYEAGTRYEDGLRILEALAATGLRSIRYAQE 120
            ..::.::.              .|||.....|...         |..|||||:||||||||||:|
pombe    89 NSELSQENLTKCDTTHDFEKNCSEKTDSTSADNIA---------GFTILEALSATGLRSIRYAKE 144

  Fly   121 IAGVRQIVANDLSRQAVASINTNIRHNKVEELIEPSHSDAMTLMYLSTQPEKRFDAVDLDPYGCP 185
            :..|::|:||||...||.:|..|:.:|.|.:::.|:..||..:|:::   :..:|.:||||||..
pombe   145 LPNVKRILANDLLENAVKTIEKNVNYNNVSDIVIPNKGDANAVMHMN---KFHYDVIDLDPYGSA 206

  Fly   186 NRFLDGAMQCLVDGGLLLVTATDMAVLAGNA-PEACYVKYGSVPLRMKCCHEMALRILLHCIESH 249
            ..|||.|:|.:...|||.:|.||.||||||| ||.|:..||...||...|||.|:|.||:.|.:.
pombe   207 APFLDAAVQSVSKDGLLCITCTDSAVLAGNAYPEKCFSNYGGSSLRSNFCHEQAVRHLLYAIAAS 271

  Fly   250 ANRYGKYIEPLLSISADFYIRIFVRVYVGQAQCKLSMSKQSWIYQCTGCETFTLQPLGITKPNPT 314
            |.:||:.|:||||:|.|||.|:||::.......|...|:...||.|:||.:|..||||.|.|...
pombe   272 AAKYGRAIKPLLSLSIDFYFRVFVQIKAKPVLVKNLQSQSLLIYHCSGCGSFAEQPLGKTSPGRL 336

  Fly   315 AGNPQQLKFGIPTGPAVNSQCEHCGHRHHLGGPIWSAPIHNPEFVQDLLTAVQETTLQSLGTQRR 379
            .|.   .||...:||.|::.|||||:.||:|||:|..|:|:.||::.:....::...:..||:||
pombe   337 PGT---TKFSNASGPPVSANCEHCGYVHHVGGPLWGGPLHDAEFLKKMRAIAEDLDPEVYGTKRR 398

  Fly   380 IVGVLSMVQEELQDVPLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSYSHASKNSLKTNAPP 444
            |:|:|::..|||.|||.|:...::|.||:.:..|...|.||:|:||||||.|||..|::|||||.
pombe   399 ILGMLALADEELPDVPFYFVLSQICSVLRSQSPPQNIFVSALLNAGYRVSGSHAKSNAIKTNAPW 463

  Fly   445 AVLWDILRSWSKRHPVNPERMIPGSPLAAILSKECTAVYEFDELHPEANPKSRKSALSRFQENPT 509
            :.:||:||||.|.|||..|.:...|..||||.|..||..:| ...|::...|:|...:|:|.|||
pombe   464 SFVWDVLRSWIKDHPVKLENISKTSAGAAILEKTPTAEVDF-TFRPDSEFASKKEGYTRYQMNPT 527

  Fly   510 PHWGPGT---RATIMIGDNK 526
            .:|||.:   :.||...|:|
pombe   528 ENWGPKSKPGKRTIAEVDSK 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6388	NP_609566.1	AdoMet_MTases	17..452	CDD:302624	186/458 (41%)
CG6388	NP_609566.1	DUF1764	<58..>103	CDD:285744	10/67 (15%)
trm1	NP_596547.1	TRM	27..471	CDD:280225	189/461 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	350	1.000	Domainoid score	I174
eggNOG	1	0.900	-	-		E1_COG1867
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5632
Inparanoid	1	1.050	398	1.000	Inparanoid score	I387
OMA	1	1.010	-	-		QHG54291
OrthoFinder	1	1.000	-	-		FOG0003425
OrthoInspector	1	1.000	-	-		oto100905
orthoMCL	1	0.900	-	-		OOG6_101071
Panther	1	1.100	-	-	LDO	PTHR10631
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1547
SonicParanoid	1	1.000	-	-		X2318
TreeFam	1	0.960	-	-
	14	13.860