DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6388 and Trmt1

DIOPT Version :9

Sequence 1:	NP_609566.1	Gene:	CG6388 / 34656	FlyBaseID:	FBgn0032430	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_001158031.1	Gene:	Trmt1 / 212528	MGIID:	1289155	Length:	663	Species:	Mus musculus

Alignment Length:	573	Identity:	270/573 - (47%)
Similarity:	350/573 - (61%)	Gaps:	49/573 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EEKPQIIAENPNENV--IRERNAEIV--SGGNVFYNPVQEFNRDLSIAALNVY-RQRL------T 58
            ||:|      |.:.|  :.|..|:||  |...|||||||||||||:.|.:..: |..|      .
Mouse    47 EERP------PADPVATVTEGAAKIVFPSANEVFYNPVQEFNRDLTCAVITEFARIHLGAKGIQI 105

  Fly    59 KERSEKALKKQRKKVKEQEDE----KTTPVPED-PPVYEAGTRYEDGLRILEALAATGLRSIRYA 118
            |...||..:|....:.:||:|    .....|.| |.....|...|:|||:||.|||:||||||:|
Mouse   106 KVPGEKDSEKIAVDLSDQEEETAGKNENLAPGDWPRTAAVGEICEEGLRVLEGLAASGLRSIRFA 170

  Fly   119 QEIAGVRQIVANDLSRQAVASINTNIRHNKVEELIEPSHSDAMTLMYLSTQPEKRFDAVDLDPYG 183
            .|:.|::.:||||.|.:||..::.|:..|.|..|::|:.:||..|||...:..:|||.:||||||
Mouse   171 LEVPGLQSVVANDASARAVELMHRNVELNGVAHLVQPNQADARMLMYQHQKAPERFDVIDLDPYG 235

  Fly   184 CPNRFLDGAMQCLVDGGLLLVTATDMAVLAGNAPEACYVKYGSVPLRMKCCHEMALRILLHCIES 248
            .|..|||.|:|.:.|||||.||.|||||||||:.|.||.|||::.|:.:.||||||||:||.::.
Mouse   236 SPAPFLDAAVQAVSDGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLDL 300

  Fly   249 HANRYGKYIEPLLSISADFYIRIFVRVYVGQAQCKLSMSKQSWIYQCTGCETFTLQPLGITKPNP 313
            |||.|.:||.||||||||||||:||||:.|||:.|.|.|||:.::||.||..|.||.||     .
Mouse   301 HANCYQRYIVPLLSISADFYIRVFVRVFTGQAKVKSSASKQALVFQCVGCGAFYLQRLG-----K 360

  Fly   314 TAGNP-QQLKFGIPTGPAVNSQCEHCGHRHHLGGPIWSAPIHNPEFVQDLLTAVQETTLQSLGTQ 377
            .:|:| .::||....||.|..:|||||.||.||||:|:.|||:.:||..:|.|| .|......|.
Mouse   361 ASGDPGGRIKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLDAV-TTNPGRFHTS 424

  Fly   378 RRIVGVLSMVQEELQDVPLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSYSHASKNSLKTNA 442
            .||.||||:|.|||.|||||||.|:|...:......:|:.|||:||||:|||.|||.||::||:|
Mouse   425 MRIQGVLSVVTEELPDVPLYYTLDQLSSTIHCNTPRLLQLRSALLHAGFRVSLSHACKNAVKTDA 489

  Fly   443 PPAVLWDILRSWSKRHPVNPERMIPGSPLAAILSKECTAVYEFDELHPEANPKSRKSALSRFQEN 507
            ||..||||:|.|.|..||..||:...||...||:.|......|: :..:|||.||:..|.|||.|
Mouse   490 PPEALWDIMRCWEKECPVKRERLSESSPAFRILAVEPRLKANFN-IREDANPSSRQRGLKRFQAN 553

  Fly   508 PTPHWGPGTRA--------TIMIGDNKLPKSYRNQNKKQRHKASEQQAEDDQQ 552
            |..:|||..||        ..:.|..:|     .|||:      ::.|||..|
Mouse   554 PEANWGPRPRARPGGKAASEDLAGRRRL-----LQNKR------KEPAEDPAQ 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6388	NP_609566.1	AdoMet_MTases	17..452	CDD:302624	228/451 (51%)
CG6388	NP_609566.1	DUF1764	<58..>103	CDD:285744	14/49 (29%)
Trmt1	NP_001158031.1	TRM	65..499	CDD:280225	225/439 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..574		16/39 (41%)
		ZnF_C3H1	599..625	CDD:214632
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838089
Domainoid	1	1.000	415	1.000	Domainoid score	I666
eggNOG	1	0.900	-	-		E1_COG1867
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5632
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1534
Isobase	1	0.950	-	0	Normalized mean entropy	S1305
OMA	1	1.010	-	-		QHG54291
OrthoDB	1	1.010	-	-		D1414511at2759
OrthoFinder	1	1.000	-	-		FOG0003425
OrthoInspector	1	1.000	-	-		oto92860
orthoMCL	1	0.900	-	-		OOG6_101071
Panther	1	1.100	-	-	LDO	PTHR10631
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1547
SonicParanoid	1	1.000	-	-		X2318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750