DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6388 and trm-1

DIOPT Version :9

Sequence 1:	NP_609566.1	Gene:	CG6388 / 34656	FlyBaseID:	FBgn0032430	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_001379156.1	Gene:	trm-1 / 179920	WormBaseID:	WBGene00006613	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	532	Identity:	235/532 - (44%)
Similarity:	320/532 - (60%)	Gaps:	41/532 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EEKPQIIAENPNENVIRERNAEIVSGGNVFYNPVQEFNRDLSIAALNVYRQRLTKERSEKALKKQ 69
            |:|.::       .||:|..|::...|.|||||||||||||::..|..:.            ...
Worm    16 EDKEEV-------TVIQEGQAKVGFHGPVFYNPVQEFNRDLTVTVLRQFS------------ADH 61

  Fly    70 RKKVKEQEDEKTTPVPEDPPVYEAGTRY-EDG-LRILEALAATGLRSIRYAQEIAGVRQIVANDL 132
            :|..:||:..||   .|:||..:..... ||| :|||:||:|:|||::|:::|:..|..|:|||.
Worm    62 QKWAEEQKQLKT---EEEPPKKKNKLAINEDGKIRILDALSASGLRALRFSKEVPNVGFIMANDF 123

  Fly   133 SRQAVASINTNIRHNKVEELIEPSHSDAMTLMYLSTQPEKRFDAVDLDPYGCPNRFLDGAMQCLV 197
            |..|||||..|::.|.||:::|....||:..|......:|||.||||||||..:.|||.|:||:.
Worm   124 SDNAVASIQENVKLNGVEDIVEAHFGDAVMTMMEHRGIDKRFHAVDLDPYGTASTFLDSAVQCVA 188

  Fly   198 DGGLLLVTATDMAVLAGNAPEACYVKYGSVPLRMKCCHEMALRILLHCIESHANRYGKYIEPLLS 262
            |.|:|:||.||||||.||.|||||.||.:|..|||||||:.|||||..|:|.||||.:|||||:|
Worm   189 DRGILMVTCTDMAVLCGNTPEACYNKYDAVTTRMKCCHEVGLRILLRAIDSAANRYTRYIEPLVS 253

  Fly   263 ISADFYIRIFVRVYVGQAQCKLSMSKQSWIYQCTGCETFTLQPLGITKPNPTAGNPQQLKFGIPT 327
            ||.|||:|:||||:.|..|.|.|.:|...:..|:||.  :::||.:.|..  .|| ||.|:.|||
Worm   254 ISVDFYVRVFVRVHTGAFQAKQSGTKVGTVLVCSGCH--SMEPLVLLKRG--EGN-QQSKYSIPT 313

  Fly   328 ------GPAVNSQCEHCGHRHHLGGPIWSAPIHNPEFVQDLLTAVQET-TLQSLGTQRRIVGVLS 385
                  ||  .::|.||....|..|||:.||||:..||..||..::.| ..:.|||..|:.|||:
Worm   314 VRHSISGP--GNRCIHCLLPLHQIGPIYLAPIHSKPFVTSLLERLKSTPEAERLGTHGRLQGVLT 376

  Fly   386 MVQEELQDVPLYYTPDKLCCVLKLEIVPMLKFRSAILHAGYRVSYSHASKNSLKTNAPPAVLWDI 450
            ||.|||.|| |||..:::..|:|:.:......|||||:||::||.||.:..::|||||..:||||
Worm   377 MVNEELDDV-LYYEHNQMANVVKVSVPKSQSVRSAILNAGFKVSGSHCNPRAIKTNAPMHLLWDI 440

  Fly   451 LRSWSKRHPVNPE-RMIPGSPLAAILSKECTAVYEFDELHPEANPKSRKSALSRFQENPTPHWGP 514
            .|..:|...|:.| |:...|....||.:..|....| .|||.|..:::|..|.|||.|...:|||
Worm   441 YRQVAKDTSVDREKRLAKESAGYHILGQPITNTVNF-TLHPGAIEQAKKENLVRFQCNKGKNWGP 504

  Fly   515 GTRATIMIGDNK 526
            ..:|...:...|
Worm   505 RQKAKGSVNSTK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6388	NP_609566.1	AdoMet_MTases	17..452	CDD:302624	208/443 (47%)
CG6388	NP_609566.1	DUF1764	<58..>103	CDD:285744	11/46 (24%)
trm-1	NP_001379156.1	TRM	9..442	CDD:396545	210/455 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	350	1.000	Domainoid score	I538
eggNOG	1	0.900	-	-		E1_COG1867
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5632
Inparanoid	1	1.050	379	1.000	Inparanoid score	I1196
Isobase	1	0.950	-	0	Normalized mean entropy	S1305
OMA	1	1.010	-	-		QHG54291
OrthoDB	1	1.010	-	-		D1414511at2759
OrthoFinder	1	1.000	-	-		FOG0003425
OrthoInspector	1	1.000	-	-		oto18434
orthoMCL	1	0.900	-	-		OOG6_101071
Panther	1	1.100	-	-	LDO	PTHR10631
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1547
SonicParanoid	1	1.000	-	-		X2318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.860