DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6405 and CIBAR1

DIOPT Version :9

Sequence 1:	NP_609564.1	Gene:	CG6405 / 34654	FlyBaseID:	FBgn0032428	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_660312.2	Gene:	CIBAR1 / 137392	HGNCID:	30452	Length:	289	Species:	Homo sapiens

Alignment Length:	316	Identity:	94/316 - (29%)
Similarity:	161/316 - (50%)	Gaps:	33/316 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFRRGKLSFLNTKDDRVKIINERINITERHLMEMCSSFALVTRKMAKYRDSFDELAKSVKSYADD 65
            |.||    .|..::.:.|.:...::..|:|..|:|..||...||.|:.||..|.|...:.:||..
Human     1 MMRR----TLENRNAQTKQLQTAVSNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINAYAAT 61

  Fly    66 EEINESLCQGLKSFTNAVTIMGDYMDINVHRLEHKIVNELAQFEQLCKSTRDNLRLAVIARDKEV 130
            |..:..|  ||.:|.:....:.||....|.|||.|:|..|..:..:.|..||:|:..:.||::|.
Human    62 ETPHLKL--GLMNFADEFAKLQDYRQAEVERLEAKVVEPLKTYGTIVKMKRDDLKATLTARNREA 124

  Fly   131 LRQRQMLELKSKFSANN---SAADSELFKAKMEVQRTNKEIDDIIGNFEQRKLRDLKQIISDFIL 192
            .:..|:...:.:..::.   |.|::||.:|.|:..||::.:::.|.|||::|::|:|.|.|:||.
Human   125 KQLTQLERTRQRNPSDRHVISQAETELQRAAMDASRTSRHLEETINNFERQKMKDIKTIFSEFIT 189

  Fly   193 IAMKQHTKALEILSASYYDIGTIDERDDFIEFQKLMKTKEELASRKTALKKGLRSQSMDSLEHEH 257
            |.|..|.||||:.:|:|.:|..|||.:|...|:..:.. .:.:||...::...:
Human   190 IEMLFHGKALEVYTAAYQNIQNIDEDEDLEVFRNSLYA-PDYSSRLDIVRANSK----------- 242

  Fly   258 LVSPLKRRPKLSRSNRNLTGAGINHGSKTEPEDETDEQDEEEDDEDEETEQSGEED 313
              |||:|    |.|.:.::|.|.....:...:.:.      |||||:|.:.:.||:
Human   243 --SPLQR----SLSAKCVSGTGQVSTCRLRKDQQA------EDDEDDELDVTEEEN 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6405	NP_609564.1	FAM92	1..222	CDD:284207	75/223 (34%)
CIBAR1	NP_660312.2	BAR_FAM92	8..218	CDD:153282	70/211 (33%)
		BAR-like. /evidence=ECO:0000305\|PubMed:27528616	10..220		71/211 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..289		8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159703
Domainoid	1	1.000	130	1.000	Domainoid score	I5207
eggNOG	1	0.900	-	-		E1_28HP5
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12234
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4562
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005047
OrthoInspector	1	1.000	-	-		otm40927
orthoMCL	1	0.900	-	-		OOG6_107237
Panther	1	1.100	-	-	LDO	PTHR21223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5493
SonicParanoid	1	1.000	-	-		X3571
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.780