DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and PKD2L1

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_057196.2	Gene:	PKD2L1 / 9033	HGNCID:	9011	Length:	805	Species:	Homo sapiens

Alignment Length:	893	Identity:	244/893 - (27%)
Similarity:	381/893 - (42%)	Gaps:	239/893 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LRDPGQSTSDKPSTSDKPSTSDKPSTSART-TVREPGPSSSPSRPVSTRESGRITFQEAAPSTSA 163
            |:..|....|.|:.|..||    |..:.|. |:...||
Human    12 LQKLGSGAWDNPAYSGPPS----PHGTLRVCTISSTGP--------------------------- 45

  Fly   164 KVVKLAASEPRPAKPPEKEGFSLFKRKKKSVGSSTPPSPSRGHRAPSIIAASALQNRAKTNRILY 228
                   .:|:|.||.::...:.::.:.    ||......:|.|.   :..:.|......||.||
Human    46 -------LQPQPKKPEDEPQETAYRTQV----SSCCLHICQGIRG---LWGTTLTENTAENRELY 96

  Fly   229 TTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVT-VGFEKL 292
                 ::..|.|..|:|:||:...|:...:..:..:|:...|.:||.:     .||.| |.|:.:
Human    97 -----IKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLH-----TPSDTGVSFQAI 151

  Fly   293 ITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPE 357
            .::.|:||:                                                       .
Human   152 SSMADFWDF-------------------------------------------------------A 161

  Fly   358 EAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHH 422
            :.|.:|.|.....||                                            |.|..|
Human   162 QGPLLDSLYWTKWYN--------------------------------------------NQSLGH 182

  Fly   423 LEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKPMHKGSPFR--- 484
            .......|||:|||.|||||::||.:||.|::.|.....:||..||...|::.|.   .||.
Human   183 GSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPF---GPFNGTA 244

  Fly   485 -TMH---DLDSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFN 545
             |.|   :|.....|..|..|..|||.::|...:..:.:.:..|::..|||||:|:..::|:::|
Human   245 WTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYN 309

  Fly   546 ENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEITEI 610
            .|.::|..::|:.|.|.|||.||...::|||:..:.::....:....:.:.:.:.||.:.||.|:
Human   310 ANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILEL 374

  Fly   611 RKSGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTAR-AHSDVTYQSLDVLCFWNIIY 674
            ....:: |..|:.||||..::|...:|:.::|:.:.:|..|..: .....||...:.|.||...|
Human   375 HIHRLR-YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQY 438

  Fly   675 VDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKH 739
            .:|.|:..|..||||||:||||||:.|.::||.||:||:.||::||.|||.||||||.|||||:.
Human   439 NNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQV 503

  Fly   740 PDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVK 804
            .:|..||..|.|..|:|||||.||.|:.|||:|||.||:||:..|||:|||||||||.:||:.||
Human   504 ENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVK 568

  Fly   805 GEITQGRSHLGSYIYRKLSGML---YWITHCGRKRRHH------------PQASETED-KDAEHD 853
            .|:...:..|      :||.:|   |..|....:.|..            .|..:.|| .:...:
Human   569 EELAGQKDEL------QLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNTLRE 627

  Fly   854 VGAAHDETHEIRKNMT-----------PAEQQYFK-DI---------------------PQGEN- 884
            :|.|..|..|:....|           ..||:..: |:                     |||::
Human   628 LGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERVALNTEIEKLGRSIVSSPQGKSG 692

  Fly   885 ------------QDMVRLNNRVGLLEEILEKLINNMDDI---LKRVEK 917
                        ::...|..||..||.:||.:::.:|.:   ||.:|:
Human   693 PEAARAGGWVSGEEFYMLTRRVLQLETVLEGVVSQIDAVGSKLKMLER 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	160/408 (39%)
PKD2L1	NP_057196.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		16/84 (19%)
		PKD_channel	147..567	CDD:400395	169/522 (32%)
		Fer4_24	702..735	CDD:407943	8/32 (25%)
		Required for homooligomerization	704..763		11/37 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	759..805
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	307	1.000	Domainoid score	I1352
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2268
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		otm40667
orthoMCL	1	0.900	-	-		OOG6_103020
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2725
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860