DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and Pkd1l2

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_036010263.1	Gene:	Pkd1l2 / 76645	MGIID:	2664668	Length:	2466	Species:	Mus musculus

Alignment Length:	880	Identity:	193/880 - (21%)
Similarity:	331/880 - (37%)	Gaps:	183/880 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RSPSGPPGPPPPRPPKTPPGASPRGTPTADSTPGDVTPARGPPPPPATKRVSIGVGSTRSAPPPA 73
            |.|.|..|    |..:.||..:|...||.:   |.:||          :.|:.|:.|..|:...|
Mouse  1623 RLPMGKDG----RQKQGPPNLTPSAQPTEE---GLLTP----------ETVTKGIQSLISSLFKA 1670

  Fly    74 TDPTGPPPTAG----KPVRDTGPSTSPRPSLRDPGQSTSDKPSTSDKPSTSDKPSTSARTTVREP 134
            ...  .||.:|    .|| |.....:....:..|  .:::.|...::....:.|.||.|.:|:..
Mouse  1671 LKV--QPPASGWDSMNPV-DINYLLTLMEDIICP--ESTEGPGFWEEAKGREDPITSTRGSVKPK 1730

  Fly   135 GPSSSPSRPVSTRESGRITFQEAAPSTSAKVVKLAASEPRPAKPPEKEGF-----------SLFK 188
            ..:..|...::.|...:.:..........:.|:      |..:....:||           .|..
Mouse  1731 ENTWHPKPELAVRGLWKDSVYRRCLYLQLEHVE------RELQLLGPQGFLHHHSHAQALRQLHV 1789

  Fly   189 RKKKSVGS-STP----PSPSRGHRAPSIIAASALQNRAKTNRILYTTDEEVREALVEFSVFIIFL 248
            .|....|. .||    ||.||..::|                          ..|..:.|.:.:|
Mouse  1790 LKGHLWGQPGTPALAYPSTSRVSKSP--------------------------RGLPWWCVLVGWL 1828

  Fly   249 IL--TSLVVLSVRHTYMFYFN--DTMKKL------FTNREMVVAPSVTVGFEKLITVPDWWDYLK 303
            ::  ||.|.......|..::.  .::|.|      |.....:..|...:||...
Mouse  1829 LVATTSGVAAFFTMLYGLHYGRVSSLKWLISMAVSFVESVFITQPLKVLGFAAF----------- 1882

  Fly   304 YNFLVTLHGDLTFMDDAQANLTSMPPEGSEQG------SEQGSEQGSEQSP-----EEVVGEAPE 357
              |.:.|.     .:|.:..|...|...|..|      |.:.|.:.:.|.|     |::.....:
Mouse  1883 --FALVLK-----REDDEETLPLFPGHLSSPGPGVLFRSRRHSSERAYQPPPMAAIEKMKTTRLK 1940

  Fly   358 EAPEMDRLQEDFKY---------------NGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSG--N 405
            |......::|...|               :.|.|   ..||..:|      :...|...|.|  .
Mouse  1941 EQKAFALIREILAYLAFLWMLLLVAYGQRDPNAY---HFHRHLER------SFSQGFSPVLGFRG 1996

  Fly   406 YLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSG 470
            :.:..:.::..|:..|| .|.|....:.|:|...:||:|||:.||.|........:.|:..||.|
Mouse  1997 FFEWANTTLVKNLYGHH-PGFVTDGNSKLVGSAHIRQVRVRESSCAVAQQLQDSLDGCHGPYSLG 2060

  Fly   471 AEDRKPMHKG---SPFRTMHDLDST------------PIWTVLAFYRTGGYTVNLDYDKDRNVKI 520
            .||.....:|   |.:...:.....            |:|..|..|..|||.|.|..|.....:|
Mouse  2061 IEDLVDYGEGWNASAYNNSNGFPQAWRYQSQSQRRGYPMWGKLTLYGGGGYVVPLGTDHQSASRI 2125

  Fly   521 INDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRS 585
            :..|.|..|||..:|...|||.::|.|.::|.::.|..|....|.......||::::|.|.....
Mouse  2126 LQYLFDNSWLDALTRAVFVEFTVYNANVNLFCTVTLTLETSGLGTFFSHVTLQSLRLYPFTDGWH 2190

  Fly   586 MLMTVIYIFWYIMVIYYTIYEITEIRKS--GIKIYFCSMLNILDCAILLGCYLALVYNIWHSFKV 648
            ..:....:.:::.:.||.:.:...:||.  |   ||||..|:|:.||:|..:.|||.     |..
Mouse  2191 PFVVAAELTYFLFLFYYMVVQGKLMRKQKWG---YFCSKWNLLEVAIILASWSALVV-----FVK 2247

  Fly   649 MSLTA-------RAHSDVTYQSLDVLCFWNIIYVD-----MMAILAFLVWIKIFKFISFNKTLVQ 701
            .::.|       |.|.|      :.:.|......|     ::|.|..|..:|::..:..|..:..
Mouse  2248 RTILADRDLQRYREHRD------EGISFSETAAADAALGYIIAFLVLLSTVKLWHLLRLNPKMNM 2306

  Fly   702 FTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIE 766
            .|:.|:|...|::||..:..|:.|||:....|:||.|...::....:..||:.:.||.|.|..:.
Mouse  2307 ITSALRRAWGDISGFVAVILIMLLAYSFASNLVFGWKLRSYKTLFDAAETMVSLQLGIFNYEEVL 2371

  Fly   767 QANRVLGPIYFLTYILLVFFILLNMFLAIIMETYN 801
            ..:.:||.:...:.|:.:.|::||:|:::|:..::
Mouse  2372 DYSPILGSLLIGSCIVFMTFVVLNLFISVILVAFS 2406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	112/431 (26%)
Pkd1l2	XP_036010263.1	CLECT	28..154	CDD:214480
		Gal_Lectin	170..252	CDD:396628
		REJ	493..866	CDD:366875
		GPS	1282..1321	CDD:396408
		PLAT_polycystin	1392..1511	CDD:238850
		PKD_channel	1987..2407	CDD:400395	113/435 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840