DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and Pkd1l2

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_038954049.1	Gene:	Pkd1l2 / 691069	RGDID:	1588631	Length:	2492	Species:	Rattus norvegicus

Alignment Length:	961	Identity:	208/961 - (21%)
Similarity:	329/961 - (34%)	Gaps:	327/961 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QSGRSPSGPPGPPP-PRPPKTPPGASPRGTPTADSTPGDVTPARGPPPPPATKRVSIGVGSTRSA 69
            ::|:...|.|.|.| |:|                :..|.:|      |...||.:...:.|...|
  Rat  1654 KNGKRKQGSPHPTPLPQP----------------TEEGLLT------PETLTKGIQSLISSLFKA 1696

  Fly    70 ---PPPAT------------------DPTGPPPTAGK-----------PVRDTGPSTSP------ 96
               ||||:                  |...|..|||:           |:..|..|..|
  Rat  1697 LKVPPPASGWDSTNQMDINSLLALMEDIVSPESTAGQEFWEEARGREDPLTFTHGSVKPEENTWH 1761

  Fly    97 ----------------RP-----------SLRDPGQSTSDKPSTSD---------KPSTSDKPST 125
                            ||           .||..|......|.:..         |.....:|.|
  Rat  1762 LGPRLAVSDLWKDSIYRPCLYIRLEHVERKLRLVGPQGFRHPHSHAQALRQLHVLKGHLWGQPGT 1826

  Fly   126 SARTTVREPGPSSSPS-RP----------VSTRESGRITF-------QEAAPSTSAKVVKLAASE 172
            .|......|..|..|. .|          |:| .||...|       .....|:...::.:|.|.
  Rat  1827 PALAYTSTPRASKCPGCLPWWCVLVGWLLVAT-TSGVAAFFTMLYGLHYGRASSLKWLISMAVSF 1890

  Fly   173 PRP---AKPPEKEGFSLF-----KRKKKS------VGSSTPPSP---SRGHRAPSIIA-----AS 215
            ...   .:|.:..||::|     ||:...      .|..:.|.|   |:..|..|..|     |:
  Rat  1891 VESVFITQPLKVLGFAVFFALVLKREDDEETLPLLPGRLSSPGPHVLSQSRRRSSKDAYRPPPAA 1955

  Fly   216 ALQNRAKTNRILYTTDEEVREALV-EFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREM 279
            |:: :.||.|:    .|:...||: |...::.||.:..||....|....::||..:::.||.
  Rat  1956 AIE-KMKTARL----KEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHFNRHLERSFTQ--- 2012

  Fly   280 VVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGS 344
                    ||..::   |:..:|::                 ||.|.:.
  Rat  2013 --------GFSAVL---DFRGFLEW-----------------ANTTLVK---------------- 2033

  Fly   345 EQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSG--VDGNSEDGSEDVSGNYL 407
                                             :|.||     ..|  .||||:
  Rat  2034 ---------------------------------NLYGH-----HPGFVTDGNSK----------- 2049

  Fly   408 KDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAE 472
                                      |:|...|||:|||:.||.|.......|:.|.|.||..||
  Rat  2050 --------------------------LVGSAHLRQVRVRESSCAVAWQLRGSFDGCRAPYSLDAE 2088

  Fly   473 D--------RKPMHKGS-------PFRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIIN 522
            |        ....|..|       .:::.......|.|..||.|..|||.|.|..|.....:|:.
  Rat  2089 DLADYGEGWNASAHNSSDGFPKVWQYQSQSRRRGYPTWGKLAVYGGGGYVVPLGTDHQSASRILQ 2153

  Fly   523 DLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSML 587
            .|.|..|||..:|...|||.::|.|.::...:.|..|....|.......||::::|.|.......
  Rat  2154 HLFDNRWLDALTRALFVEFTVYNANVNLLCCVTLTLETSGLGTFFSHVTLQSLRLYPFTDGWHPF 2218

  Fly   588 MTVIYIFWYIMVIYYTIYEITEIRKS--GIKIYFCSMLNILDCAILLGCYLALVY---------- 640
            :.|..:.:::.:.||.:.:...:||.  |   ||||..|:|:.||:|..:.|||.
  Rat  2219 VVVAELVYFLFLFYYMVEQGKLMRKQKWG---YFCSKWNLLELAIILASWSALVVFVKRAVLADR 2280

  Fly   641 NIWHSFK------VMSLTARAHSDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTL 699
            ::.|..|      ..|.||.|.:.:.|               ::|.|..|..:|::..:..|..:
  Rat  2281 DLQHYRKNRGEGVSFSETAAADAALGY---------------IIAFLVLLSTVKLWHLLRLNPKM 2330

  Fly   700 VQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNL 764
            ...|:.|:....|::||..:..|:.|||:....|:||.|...::....:..|||.:.||.|.|..
  Rat  2331 NMITSALRSAWGDISGFVTVILIMLLAYSIASHLIFGWKLRSYKTLFDAAETMISLQLGIFNYEE 2395

  Fly   765 IEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYN--------TVKGEI 807
            :...:.|||.:...:.|:.:.|::||:|:::|:..::        :.:|||
  Rat  2396 VLDYSPVLGSLLIGSCIVFMTFVVLNLFISVILVAFSEEQKSDQLSEEGEI 2446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	110/441 (25%)
Pkd1l2	XP_038954049.1	CLECT	70..186	CDD:153057
		Gal_Lectin	201..283	CDD:396628
		REJ	<697..894	CDD:366875
		GPS	1308..1347	CDD:396408
		PLAT_polycystin	1418..1537	CDD:238850
		PKD_channel	2013..2433	CDD:400395	125/548 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910