Protein Alignment Pkd2 and pkd2l1

DIOPT Version :10

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_695404.4
• Gene: pkd2l1 / 567026
• ZFINID: ZDB-GENE-030616-558
• Length: 862
• Species: Danio rerio
• Alignment Length: 844
• Identity: 234/844 - (27%)
• Similarity: 371/844 - (43%)
• Gaps: 196/844 - (23%)

  Fly   137 SSSPS---RPVSTRESGRITFQEAAPSTSAKVVKLAASEPRPAKPPEKEGFSLFKRKKKSVGSST 198
            |.||:   |||||..|                       |:|......|...|.:.|.:::.:..
Zfish    87 SGSPAAVRRPVSTIYS-----------------------PQPGFHSPLENPYLNQDKARTMPNED 128

  Fly   199 PPSP--SRGHRAPSIIAASALQNRAKTNRILYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHT 261
            ..|.  |...||...:..:||:...|.|..|     .|:..|.|..::|:||:...|:...:..:
Zfish   129 KKSGCCSFFFRAIKGLWGTALRKDTKENPEL-----NVKANLKELLIYIVFLVDLCLLTYGMTSS 188

  Fly   262 YMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTS 326
            ..:|:...|..||.|    :..|..:.|..:..:.|.|.|:
Zfish   189 ATYYYTKAMTDLFVN----LPGSNGMSFSSIGCMNDVWTYM------------------------ 225

  Fly   327 MPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGV 391
                                           |.|.:|.|.....||..|.
Zfish   226 -------------------------------EGPLLDNLYWTKWYNDEPL--------------- 244

  Fly   392 DGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAF 456
                |:|                  |.||       ..|||||||.||:||::|::.||.|...|
Zfish   245 ----ENG------------------NQSF-------IYYENLLLGVPRVRQLKVKQNSCKVPTDF 280

  Fly   457 IRYFNTCYAAYSSGAEDRKP--MHKGS--PFRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRN 517
            .:..:.|:..|:...||...  :..|:  .:.:..::..:..|.:|..|...|:..:|...:|.:
Zfish   281 KKEISDCFDVYNIKKEDDGAFGLINGTAWQYHSEKEIKGSSHWGLLTTYSGAGFYQDLTTTRDES 345

  Fly   518 VKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFT 582
            ..::.||::..|||||:|:..::|..:|.|.::|..|:|:.|.|.|||.||...::|||:..:.|
Zfish   346 AALLEDLRENLWLDRGTRVLFIDFTAYNANINLFCVIRLVVEFPATGGAIPSYQIRTVKLIRYVT 410

  Fly   583 DRSMLMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFK 647
            .....:....|.:.:.::||.:.||.|.|...:. :|.|:.||||..::|...:|:|::.:.:.|
Zfish   411 TWDYFIIGCEIVFCVFILYYIVEEILEFRIHKLS-HFTSIWNILDIVVILLAVVAIVFSAFRTIK 474

  Fly   648 VMSLTAR--AHSDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCS 710
            |..|...  ...|: |...:.|.||...|.:|.|:..|..||||||:||||||:.|.|:||.||:
Zfish   475 VDGLLGNLLKQPDI-YADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLTSTLARCA 538

  Fly   711 KDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPI 775
            .|:.||::||.|||.||||||.|||||:...|..|...|.|..|:|||||.|:.|::||||||||
Zfish   539 LDIFGFAIMFFIVFFAYAQLGYLLFGTEVETFSTFNKCIFTQFRIILGDFDYDAIDRANRVLGPI 603

  Fly   776 YFLTYILLVFFILLNMFLAIIMETYNTVKGEITQGR-----------SHLGSYIYRKL------- 822
            ||.:|:..|||:|||||||||.:||:.||.|:...:           |:..:::..||
Zfish   604 YFFSYVFFVFFVLLNMFLAIINDTYSEVKSELASQKDEFQIADLIKQSYAKTFMKLKLKKEKISD 668

  Fly   823 ------SG-----------MLYWITHCGRK-----RRHHPQASETEDKDAEHDV--------GAA 857
                  ||           .|..:.|..|:     .:.....::|.||..:.::        .|.
Zfish   669 VQKALDSGASELEFKDFRNALKEMGHSDREISAAFSKFDQDGNQTLDKQEQENMKQELEEKRDAL 733

  Fly   858 HDETHEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRVGLLEEILEKLINNMDDILKRVEKDYHN 921
            ..|..::..::.||| ::...:|.   :|..||.::|..||..:..:::.:|.:::::.....|
Zfish   734 SAELRDLENSVEPAE-EHRNTVPP---EDYQRLVHKVSQLENSVSAIMSKLDFVMEKMRLQTFN 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	DUF5585	<29..272	CDD:465521	32/139 (23%)
		Polycystin_dom	404..578	CDD:466668	54/177 (31%)
		PKD_channel	579..803	CDD:462341	103/225 (46%)
pkd2l1	XP_695404.4	None