DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and pkd2l1

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_695404.3	Gene:	pkd2l1 / 567026	ZFINID:	ZDB-GENE-030616-558	Length:	805	Species:	Danio rerio

Alignment Length:	844	Identity:	234/844 - (27%)
Similarity:	371/844 - (43%)	Gaps:	196/844 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 SSSPS---RPVSTRESGRITFQEAAPSTSAKVVKLAASEPRPAKPPEKEGFSLFKRKKKSVGSST 198
            |.||:   |||||..|                       |:|......|...|.:.|.:::.:..
Zfish    30 SGSPAAVRRPVSTIYS-----------------------PQPGFHSPLENPYLNQDKARTMPNED 71

  Fly   199 PPSP--SRGHRAPSIIAASALQNRAKTNRILYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHT 261
            ..|.  |...||...:..:||:...|.|..|     .|:..|.|..::|:||:...|:...:..:
Zfish    72 KKSGCCSFFFRAIKGLWGTALRKDTKENPEL-----NVKANLKELLIYIVFLVDLCLLTYGMTSS 131

  Fly   262 YMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTS 326
            ..:|:...|..||.|    :..|..:.|..:..:.|.|.|:
Zfish   132 ATYYYTKAMTDLFVN----LPGSNGMSFSSIGCMNDVWTYM------------------------ 168

  Fly   327 MPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGV 391
                                           |.|.:|.|.....||..|.
Zfish   169 -------------------------------EGPLLDNLYWTKWYNDEPL--------------- 187

  Fly   392 DGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAF 456
                |:|                  |.||       ..|||||||.||:||::|::.||.|...|
Zfish   188 ----ENG------------------NQSF-------IYYENLLLGVPRVRQLKVKQNSCKVPTDF 223

  Fly   457 IRYFNTCYAAYSSGAEDRKP--MHKGS--PFRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRN 517
            .:..:.|:..|:...||...  :..|:  .:.:..::..:..|.:|..|...|:..:|...:|.:
Zfish   224 KKEISDCFDVYNIKKEDDGAFGLINGTAWQYHSEKEIKGSSHWGLLTTYSGAGFYQDLTTTRDES 288

  Fly   518 VKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFT 582
            ..::.||::..|||||:|:..::|..:|.|.::|..|:|:.|.|.|||.||...::|||:..:.|
Zfish   289 AALLEDLRENLWLDRGTRVLFIDFTAYNANINLFCVIRLVVEFPATGGAIPSYQIRTVKLIRYVT 353

  Fly   583 DRSMLMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFK 647
            .....:....|.:.:.::||.:.||.|.|...:. :|.|:.||||..::|...:|:|::.:.:.|
Zfish   354 TWDYFIIGCEIVFCVFILYYIVEEILEFRIHKLS-HFTSIWNILDIVVILLAVVAIVFSAFRTIK 417

  Fly   648 VMSLTAR--AHSDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCS 710
            |..|...  ...|: |...:.|.||...|.:|.|:..|..||||||:||||||:.|.|:||.||:
Zfish   418 VDGLLGNLLKQPDI-YADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLTSTLARCA 481

  Fly   711 KDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPI 775
            .|:.||::||.|||.||||||.|||||:...|..|...|.|..|:|||||.|:.|::||||||||
Zfish   482 LDIFGFAIMFFIVFFAYAQLGYLLFGTEVETFSTFNKCIFTQFRIILGDFDYDAIDRANRVLGPI 546

  Fly   776 YFLTYILLVFFILLNMFLAIIMETYNTVKGEITQGR-----------SHLGSYIYRKL------- 822
            ||.:|:..|||:|||||||||.:||:.||.|:...:           |:..:::..||
Zfish   547 YFFSYVFFVFFVLLNMFLAIINDTYSEVKSELASQKDEFQIADLIKQSYAKTFMKLKLKKEKISD 611

  Fly   823 ------SG-----------MLYWITHCGRK-----RRHHPQASETEDKDAEHDV--------GAA 857
                  ||           .|..:.|..|:     .:.....::|.||..:.::        .|.
Zfish   612 VQKALDSGASELEFKDFRNALKEMGHSDREISAAFSKFDQDGNQTLDKQEQENMKQELEEKRDAL 676

  Fly   858 HDETHEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRVGLLEEILEKLINNMDDILKRVEKDYHN 921
            ..|..::..::.||| ::...:|.   :|..||.::|..||..:..:::.:|.:::::.....|
Zfish   677 SAELRDLENSVEPAE-EHRNTVPP---EDYQRLVHKVSQLENSVSAIMSKLDFVMEKMRLQTFN 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	157/406 (39%)
pkd2l1	XP_695404.3	PKD_channel	153..574	CDD:285288	170/521 (33%)
		UPF0118	358..>499	CDD:294317	55/142 (39%)
		DegS	566..>691	CDD:283127	21/124 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	295	1.000	Domainoid score	I1460
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2331
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		otm26400
orthoMCL	1	0.900	-	-		OOG6_103020
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2725
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.900