Protein Alignment Pkd2 and pkd1b

DIOPT Version :9

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_021335980.1
• Gene: pkd1b / 565697
• ZFINID: ZDB-GENE-100707-2
• Length: 4007
• Species: Danio rerio
• Alignment Length: 845
• Identity: 152/845 - (17%)
• Similarity: 301/845 - (35%)
• Gaps: 224/845 - (26%)

  Fly    34 TPTADSTPGDVTPARGPPPPPATKRVSIGVGSTRSAPPPATDPTGPPPTAGKPVRDTGPSTSPRP 98
            |||:|...|::..:........|....:.:.:|.|:.|.|:|.....|      .||.|:
Zfish  3036 TPTSDHDNGELAKSSASEEDLRTISPDMDLTNTLSSDPEASDSGNFTP------NDTIPT----- 3089

  Fly    99 SLRDPGQSTSDKPSTSDKPSTSDKPSTSARTTVREPGPSSSPSRPVSTRESGRITFQEAAPSTSA 163
                         .|.|. ..|:....|..|...|||                  |..::.|.|
Zfish  3090 -------------DTQDS-FCSEWSDLSVDTPTYEPG------------------FHRSSSSLS- 3121

  Fly   164 KVVKLAASEPRPAKPPEKEGFSLFKRKKKSVGSSTPPSPSRGHRAPSIIAASALQNRAKTNRILY 228
              |...||...|:.||  :..|.....:..|....|     |...||.:.           |:::
Zfish  3122 --VLSEASTFLPSLPP--DSISTVSTTRIGVVRGVP-----GFYLPSWVL-----------RMVH 3166

  Fly   229 TTDEEVREALVEFSVFIIFLILTSLVVLSV------RHTYMFYFNDTMKKLFTNREMVVAPSVTV 287
                          :.:..|:.|.|.|:.:      ....:.:...|:..:.|:..::...::.:
Zfish  3167 --------------LLVAVLLGTCLAVVGLYGSSFTSSVVLMWLVSTLSAVLTSALLLEPLAICI 3217

  Fly   288 GFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVV 352
            ....|.||                            :..:.||..|:.:::...:.||:...:.|
Zfish  3218 QALYLATV----------------------------VRPVDPEVEERLAQETEVRRSEEDFRDKV 3254

  Fly   353 G--------EAPEEAPEMDRLQEDFK--------------YNGNPYIDLRGHRR---AKRQSGVD 392
            .        :|.|||.::..|:...:              .|...::.:...||   |.:.:.:.
Zfish  3255 HPLCGYGLLQAKEEARKLRTLRALMRSCLVYMLFLLVVLMVNYQEHVQMADSRRLHSAIKHTLIS 3319

  Fly   393 GNS-EDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYEN---LLLGPPRLRQIRVRKESCY-- 451
            .:: :.|...:||  ..:....|...::.|       ||||   ||.||.||:::.. ::.|.
Zfish  3320 ASAGKPGLMKLSG--WMNAEQWINEKLTSH-------LYENPSLLLTGPARLQKVYF-QDFCSQG 3374

  Fly   452 VNDAFIRYFNTCYAAYSSGAEDRKP-------MHKGSPFRTMHDLDSTP---IW---TVLAFYRT 503
            :.|.|           .||.....|       .:.|....|.|. .:||   .|   .:.||.:|
Zfish  3375 IRDQF-----------QSGRLSLMPTAHVSSHANPGQQTSTAHS-KNTPALSTWQKRALCAFSQT 3427

  Fly   504 GGYTV--NLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGV 566
            ....:  |.:|.:    :|::||:...|:..|::..|:||..:::.|.|...:.::.:...||.:
Zfish  3428 EELVLGNNTEYTR----QILSDLQKEKWMTTGTKAVLIEFTQYHKQTSILAPVSILLDQTQTGRI 3488

  Fly   567 IPQAHLQTVKMYSFF-TDRSMLMTVIYIFWYIMVIYYTIYEITEIR------KSGIKIYFCSMLN 624
            :....:|...:.... .|..:.:||      :::::...:..||:|      ...::..:|....
Zfish  3489 LAFISIQPFHISPLSGPDLHVTLTV------VLLLFALCFLSTEVRALIRKPSQYLRQAWCWFQT 3547

  Fly   625 ILDCAILLGCYLALVY------------NIWHSFKVMSLTARAHSDVTYQSLDVLCFWNIIYVDM 677
            :|....|....|.|.:            :|..||      |..||..|.....         ..:
Zfish  3548 LLALLALAAAVLRLYFLYTTTVCISRYRSIPSSF------ADFHSAATVARKS---------NQL 3597

  Fly   678 MAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDF 742
            .|||..|:.:|:...:.|.:..:.....:.:....:.|...:..::.|.::.:|::||......|
Zfish  3598 SAILLTLLALKMVGILQFVRRWLVMGRVIWQVFPQICGVVFLLLLLLLLFSHIGMMLFSGSVEGF 3662

  Fly   743 RNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEI 807
            |....:..:::.::.|......:.:.:.|:||:|.|:.:.:.|::|..:..|:::.||..|:.:|
Zfish  3663 RTLGQASSSLLCLLRGRTGLQRLCEHHPVVGPLYCLSAVGIGFWVLGRLCAAVLIRTYQMVQADI 3727

  Fly   808  807
            Zfish  3728  3727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	86/439 (20%)
pkd1b	XP_021335980.1	PCC	25..2314	CDD:188093
		GPS	2590..2636	CDD:321989
		PLAT_polycystin	2697..2815	CDD:238850
		PKD_channel	3302..3720	CDD:332708	88/464 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740