Protein Alignment Pkd2 and Pkd2l2

DIOPT Version :9

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_017173433.1
• Gene: Pkd2l2 / 53871
• MGIID: 1858231
• Length: 623
• Species: Mus musculus
• Alignment Length: 733
• Identity: 216/733 - (29%)
• Similarity: 332/733 - (45%)
• Gaps: 170/733 - (23%)

  Fly   228 YTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKL 292
            |..:.||...|.|..::.||||...::...:.:.:|:|.|..|..||.:
Mouse    21 YRREAEVNTTLEELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFVD---------------- 69

  Fly   293 ITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPE 357
                                            ||:|.:          |:.|.:|...:.
Mouse    70 --------------------------------TSLPDD----------ERSSFRSIRSIT----- 87

  Fly   358 EAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHH 422
                     |.:|:...|.||                         |.|.    ||...|...:.
Mouse    88 ---------EFWKFMEGPLID-------------------------GLYW----DSWYGNKQLYS 114

  Fly   423 LE--GRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAED------------ 473
            ::  .|:: |||:|||.||:||:|||..:|.|..||....:.||:.|:...||
Mouse   115 VKNSSRIY-YENVLLGIPRVRQLRVRNNTCKVYPAFQSLVSDCYSKYTVENEDFSDFGLKRNPEW 178

  Fly   474 -RKPMHKGSPFRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLC 537
             ..|..:.:|:.          |..:..||.|||.|.|...|........||:..:|:.||:|..
Mouse   179 THTPSSRTAPWH----------WGFVGVYRDGGYIVTLSKSKSETKAKFVDLRLNNWISRGTRAV 233

  Fly   538 LVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKM------YSFFTDRSMLMTVIYIFWY 596
            .::|:|:|.|.::|..|:|:||.|.|||::......:||:      |.:|.....::..|::|.:
Mouse   234 FIDFSLYNANVNLFCIIRLLAEFPATGGLLTSWQFYSVKLLRYVSYYDYFIASCEVIFCIFLFVF 298

  Fly   597 IMVIYYTIYEITEIRKSG--IKIYFCSMLNILDCAILLGCYLAL---VYNIWHSFKVMSLTARAH 656
            |         |.|:||..  ...||.|:.|.|:..:||.|:||:   .|....||.::....: :
Mouse   299 I---------IQELRKVNEFKSAYFRSVWNWLEMLLLLLCFLAVSFYAYCNMQSFLLLGQLLK-N 353

  Fly   657 SDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFG 721
            :| :|.....|.:|:|.|.:::||..|..|||||||||||:|:.|.::||.||.||:.||::||.
Mouse   354 TD-SYPDFYFLAYWHIYYNNVIAITIFFAWIKIFKFISFNETMSQLSSTLSRCMKDIVGFAIMFF 417

  Fly   722 IVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFF 786
            |:|.||||||.|:||::..||..|..||....|::||||.:..|:|||.:||||||:|:|..|||
Mouse   418 IIFSAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANWILGPIYFITFIFFVFF 482

  Fly   787 ILLNMFLAIIMETYNTVKGEITQGRS---HLGSYIYRKLSGMLYWITHCGRKRRHHPQASETEDK 848
            :|||||||||.:||:.||.:.:.||.   .||..|.:....:|      .:.|....||.| |.|
Mouse   483 VLLNMFLAIINDTYSEVKADYSIGRRPDFELGKIIQKSCFNVL------EKLRLKKAQAKE-EKK 540

  Fly   849 DAEHDVG--AAHD--------ETHEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRVGLLEEI-LE 902
            ....|:.  |..|        |..::::.....|::|:....|.:.|.:.:...|...|..: ||
Mouse   541 MQTTDLAQRARRDGFDESEIQEAEQMKRWKERLEKKYYSTEIQDDYQPVTQQEFRELFLYAVELE 605

  Fly   903 KLINNMDDILKRVEKDYH 920
            |.::.:...|.::.:..|
Mouse   606 KELHYVSLKLNQLMRKLH 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	161/426 (38%)
Pkd2l2	XP_017173433.1	PKD_channel	78..499	CDD:369653	168/485 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841950
Domainoid	1	1.000	313	1.000	Domainoid score	I1300
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2221
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		otm42741
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.860