DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pkd2 and PKD2

DIOPT Version :9

Sequence 1:NP_609561.2 Gene:Pkd2 / 34651 FlyBaseID:FBgn0041195 Length:924 Species:Drosophila melanogaster
Sequence 2:NP_000288.1 Gene:PKD2 / 5311 HGNCID:9009 Length:968 Species:Homo sapiens


Alignment Length:961 Identity:253/961 - (26%)
Similarity:390/961 - (40%) Gaps:235/961 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 QQGQSGRSPSGPPGPPPPRPPKTPPGASPRGTPTADSTPGDVTPARGPPPPPATKRVSIGVGSTR 67
            |.|.:.|    ||.|..|.|.:...|.:..|...|  .||.:...||         :.|.:...|
Human    11 QPGDAKR----PPAPRAPDPGRLMAGCAAVGASLA--APGGLCEQRG---------LEIEMQRIR 60

  Fly    68 SAPPPATDPTGPPPTAGKPVRDTGPSTSPRPSLRDPGQSTSDKPSTSDKPSTSDKPSTSARTTVR 132
            .|  .|.||            ..|.:.||.|.|          .|.|.:..:.|.|...|.....
Human    61 QA--AARDP------------PAGAAASPSPPL----------SSCSRQAWSRDNPGFEAEEEEE 101

  Fly   133 EPGPSSSPSRPVSTRESGRITFQE------AAPSTSAKVVKLAASEPRPAKPPEKEGFSLFKRKK 191
            |          |...|.|.:...:      :..|.::..|....:..|........|....:|::
Human   102 E----------VEGEEGGMVVEMDVEWRPGSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRR 156

  Fly   192 KSVGSSTPPSPSRG----HR------APSIIA-------------ASALQNRAKTNRILYTTDEE 233
            :.......|||..|    ||      .|..:|             .:.|...:.|||..|     
Human   157 REDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKY----- 216

  Fly   234 VREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDW 298
            ::..|.|...:::|||:..::...:..:.::|:...|.:||.  :..|:.:....|:.|.::.|:
Human   217 LKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFL--DTPVSKTEKTNFKTLSSMEDF 279

  Fly   299 WDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMD 363
            |.:.:.:.|..|:..:                                        .|....|.|
Human   280 WKFTEGSLLDGLYWKM----------------------------------------QPSNQTEAD 304

  Fly   364 RLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVF 428
                                                                 |.||       .
Human   305 -----------------------------------------------------NRSF-------I 309

  Fly   429 LYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKPM--HKGSP--FRTMHDL 489
            .|||||||.||:||:|||..||.:..........||..||..:|||.|.  ..|:.  :.:..||
Human   310 FYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDL 374

  Fly   490 DSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSI 554
            :.:..|.::|.|...||.::|...::.....:..||...|||||:|...::|:::|.|.::|..:
Human   375 NGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVV 439

  Fly   555 KLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYF 619
            :|:.|.|.||||||....|.:|:..:.|.....:....|.:...:.||.:.||.|||...:. ||
Human   440 RLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLH-YF 503

  Fly   620 CSMLNILDCAILLGCYLALVYNIWHSFKVMSLTARAHSDVTYQSLDVLCFWNIIYVDMMAILAFL 684
            .|..|.||..|::...:|:..||:.:..|..|........|:.:.:.|.:|.|.:.::.|:..|.
Human   504 RSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFF 568

  Fly   685 VWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSI 749
            ||||:||||:||:|:.|.:||:.||:|||.||::||.|:|||||||..|:|||:..||..|...|
Human   569 VWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECI 633

  Fly   750 LTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEITQGRSHL 814
            .|..|:||||..:..||:||||||||||.|::..:||||||||||||.:||:.||.::.|.::.:
Human   634 FTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEM 698

  Fly   815 GSYIYRKLSGMLYWITHCGRKRRHHPQASETEDKDAEHDV---------------------GAAH 858
                  :||.::       ||..|.........|:...|:                     |..|
Human   699 ------ELSDLI-------RKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGH 750

  Fly   859 DETHEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRVGLLEEILEKLINNMD 909
            .:. ||....|..:|...:::.:.|:|.|          .:.|||...::|
Human   751 TDA-EIEAIFTKYDQDGDQELTEHEHQQM----------RDDLEKEREDLD 790

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkd2NP_609561.2 PKD_channel 402..803 CDD:285288 158/404 (39%)
PKD2NP_000288.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28 8/20 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 58..181 30/156 (19%)
PKD_channel 269..687 CDD:400395 167/518 (32%)
Selectivity filter. /evidence=ECO:0000305|PubMed:28092368 641..643 1/1 (100%)
EFh_HEF <724..792 CDD:355006 14/78 (18%)
EF-hand motif 754..782 CDD:320075 7/37 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..831 8/37 (22%)
Linker. /evidence=ECO:0000305|PubMed:18694932 803..822
Important for interaction with PACS1 and PACS2. /evidence=ECO:0000269|PubMed:15692563 810..821
Fer4_24 834..868 CDD:407943
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 917..968
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151823
Domainoid 1 1.000 307 1.000 Domainoid score I1352
eggNOG 1 0.900 - - E1_KOG3599
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 352 1.000 Inparanoid score I2268
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D205541at33208
OrthoFinder 1 1.000 - - FOG0002518
OrthoInspector 1 1.000 - - otm40667
orthoMCL 1 0.900 - - OOG6_103020
Panther 1 1.100 - - O PTHR10877
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2725
SonicParanoid 1 1.000 - - X1653
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.790

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