Protein Alignment Pkd2 and PKD2

DIOPT Version :10

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_000288.1
• Gene: PKD2 / 5311
• HGNCID: 9009
• Length: 968
• Species: Homo sapiens
• Alignment Length: 961
• Identity: 253/961 - (26%)
• Similarity: 390/961 - (40%)
• Gaps: 235/961 - (24%)

  Fly     3 QQGQSGRSPSGPPGPPPPRPPKTPPGASPRGTPTADSTPGDVTPARGPPPPPATKRVSIGVGSTR 67
            |.|.:.|    ||.|..|.|.:...|.:..|...|  .||.:...||         :.|.:...|
Human    11 QPGDAKR----PPAPRAPDPGRLMAGCAAVGASLA--APGGLCEQRG---------LEIEMQRIR 60

  Fly    68 SAPPPATDPTGPPPTAGKPVRDTGPSTSPRPSLRDPGQSTSDKPSTSDKPSTSDKPSTSARTTVR 132
            .|  .|.||            ..|.:.||.|.|          .|.|.:..:.|.|...|.....
Human    61 QA--AARDP------------PAGAAASPSPPL----------SSCSRQAWSRDNPGFEAEEEEE 101

  Fly   133 EPGPSSSPSRPVSTRESGRITFQE------AAPSTSAKVVKLAASEPRPAKPPEKEGFSLFKRKK 191
            |          |...|.|.:...:      :..|.::..|....:..|........|....:|::
Human   102 E----------VEGEEGGMVVEMDVEWRPGSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRR 156

  Fly   192 KSVGSSTPPSPSRG----HR------APSIIA-------------ASALQNRAKTNRILYTTDEE 233
            :.......|||..|    ||      .|..:|             .:.|...:.|||..|
Human   157 REDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKY----- 216

  Fly   234 VREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDW 298
            ::..|.|...:::|||:..::...:..:.::|:...|.:||.  :..|:.:....|:.|.::.|:
Human   217 LKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFL--DTPVSKTEKTNFKTLSSMEDF 279

  Fly   299 WDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMD 363
            |.:.:.:.|..|:..:                                        .|....|.|
Human   280 WKFTEGSLLDGLYWKM----------------------------------------QPSNQTEAD 304

  Fly   364 RLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVF 428
                                                                 |.||       .
Human   305 -----------------------------------------------------NRSF-------I 309

  Fly   429 LYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKPM--HKGSP--FRTMHDL 489
            .|||||||.||:||:|||..||.:..........||..||..:|||.|.  ..|:.  :.:..||
Human   310 FYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDL 374

  Fly   490 DSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSI 554
            :.:..|.::|.|...||.::|...::.....:..||...|||||:|...::|:::|.|.::|..:
Human   375 NGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVV 439

  Fly   555 KLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYF 619
            :|:.|.|.||||||....|.:|:..:.|.....:....|.:...:.||.:.||.|||...:. ||
Human   440 RLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLH-YF 503

  Fly   620 CSMLNILDCAILLGCYLALVYNIWHSFKVMSLTARAHSDVTYQSLDVLCFWNIIYVDMMAILAFL 684
            .|..|.||..|::...:|:..||:.:..|..|........|:.:.:.|.:|.|.:.::.|:..|.
Human   504 RSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFF 568

  Fly   685 VWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSI 749
            ||||:||||:||:|:.|.:||:.||:|||.||::||.|:|||||||..|:|||:..||..|...|
Human   569 VWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECI 633

  Fly   750 LTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEITQGRSHL 814
            .|..|:||||..:..||:||||||||||.|::..:||||||||||||.:||:.||.::.|.::.:
Human   634 FTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEM 698

  Fly   815 GSYIYRKLSGMLYWITHCGRKRRHHPQASETEDKDAEHDV---------------------GAAH 858
                  :||.::       ||..|.........|:...|:                     |..|
Human   699 ------ELSDLI-------RKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGH 750

  Fly   859 DETHEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRVGLLEEILEKLINNMD 909
            .:. ||....|..:|...:::.:.|:|.|          .:.|||...::|
Human   751 TDA-EIEAIFTKYDQDGDQELTEHEHQQM----------RDDLEKEREDLD 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	DUF5585	<29..272	CDD:465521	51/271 (19%)
		Polycystin_dom	404..578	CDD:466668	59/177 (33%)
		PKD_channel	579..803	CDD:462341	99/223 (44%)
PKD2	NP_000288.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		8/20 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	58..181		30/156 (19%)
		Polycystin_dom	269..463	CDD:466668	68/293 (23%)
		PKD_channel	464..687	CDD:462341	99/223 (44%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:28092368	641..643		1/1 (100%)
		EFh_HEF	<724..792	CDD:355006	14/78 (18%)
		EF-hand motif	754..782	CDD:320075	7/37 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..831		8/37 (22%)
		Linker. /evidence=ECO:0000305|PubMed:18694932	803..822
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000269|PubMed:15692563	810..821
		Fer4_24	834..868	CDD:436280
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	917..968