Protein Alignment Pkd2 and PKD1

DIOPT Version :9

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_024306066.1
• Gene: PKD1 / 5310
• HGNCID: 9008
• Length: 4343
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 116/547 - (21%)
• Similarity: 200/547 - (36%)
• Gaps: 115/547 - (21%)

  Fly   435 LGPPRLRQIRVRKESCYVNDAFIRYFNTCYAA-------YSSGAEDRKPMHKGS-------PFRT 485
            ||||||||:|: :|:.|.:....| .:||.||       |..|.|.   .|.||       |
Human  3784 LGPPRLRQVRL-QEALYPDPPGPR-VHTCSAAGGFSTSDYDVGWES---PHNGSGTWAYSAP--- 3840

  Fly   486 MHDLDSTPIWTVLAFYRTGGYT----VNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNE 546
              ||.....|...|.|.:|||.    ::|:..:||    :..|:..:|||..||...:|...::.
Human  3841 --DLLGAWSWGSCAVYDSGGYVQELGLSLEESRDR----LRFLQLHNWLDNRSRAVFLELTRYSP 3899

  Fly   547 NTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSM-LMTVIYIFWYIMVIYYTIYEITEI 610
            ...:..::.|..|.|..|..:....::...:.......|: |:|.:.:.  :..:::.:.|....
Human  3900 AVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLL--LFAVHFAVAEARTW 3962

  Fly   611 RKSGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTA-----------RAHSDVT---- 660
            .:.                   |.:..|....|..:.:::|||           .|....|
Human  3963 HRE-------------------GRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVR 4008

  Fly   661 -----YQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMF 720
                 :.|.|.:...:.....:.|.|.||:.:|..:.:.|.:....|..||.|...:|.|.:|..
Human  4009 GRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGL 4073

  Fly   721 GIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMIL----GDFQYNLIEQANRVLGPIYFLTYI 781
            .::.:|||||.:||..       :.:.|:.::.:.:|    |.....|....:..|.|:..:...
Human  4074 VVLGVAYAQLAILLVS-------SCVDSLWSVAQALLVLCPGTGLSTLCPAESWHLSPLLCVGLW 4131

  Fly   782 LLVFFILLNMFLAIIMETYNTVKGEITQGRSHLGSY--IYRKLSGMLYWITHCGRKRRHH----- 839
            .|..:..|.:...|:...|:.::||:.:.......|  :...|..:..|:.....|...|
Human  4132 ALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFE 4196

  Fly   840 -----PQASETEDKDAEHDV---GAAHDETHEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRV-- 894
                 |..|....| ...||   .|..|.:|.    .|.:.|.      .|.:..:.||..|.
Human  4197 GMEPLPSRSSRGSK-VSPDVPPPSAGSDASHP----STSSSQL------DGLSVSLGRLGTRCEP 4250

  Fly   895 --GLLEEILEKLINNMDDILKRVEKDY 919
              ..|:.:.|.|:...|.:.:..|..|
Human  4251 EPSRLQAVFEALLTQFDRLNQATEDVY 4277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	89/410 (22%)
PKD1	XP_024306066.1	LRR	<50..>126	CDD:227223
		leucine-rich repeat	70..92	CDD:275378
		leucine-rich repeat	93..116	CDD:275378
		PCC	97..2768	CDD:188093
		leucine-rich repeat	117..129	CDD:275378
		GPS	3051..3100	CDD:197639
		PLAT_polycystin	3158..3277	CDD:238850
		PKD_channel	3751..4153	CDD:332708	89/410 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151821
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740