Protein Alignment Pkd2 and Pkd2

DIOPT Version :10

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_001178863.1
• Gene: Pkd2 / 498328
• RGDID: 1559992
• Length: 966
• Species: Rattus norvegicus
• Alignment Length: 1026
• Identity: 264/1026 - (25%)
• Similarity: 410/1026 - (39%)
• Gaps: 279/1026 - (27%)

  Fly     7 SGRSPSGPPGPP--PPRPPKTPPG---ASPRGTPTADSTPGDVTPARGPPPPPATKRVSIGVGST 66
            |.|....|||.|  .|.|..:.||   |...|.    :.||.:...||         :.|.:...
  Rat     4 SSRVQPQPPGDPGRSPAPRASGPGRLLAGGAGL----AVPGGLREQRG---------LEIEMERI 55

  Fly    67 RSAPPPATDPTGPPPTAGKPVRDTGPSTSPRPSLRDPGQSTSDKPSTSDKPSTSDKPSTSARTTV 131
            |.|  .|.||            ..|.|.||.|.|          .|.|.:..:.|.|...|.
  Rat    56 RQA--AARDP------------PAGASASPSPPL----------SSCSRQAWSRDNPGFEAE--- 93

  Fly   132 REPGPSSSPSRPVSTRESGRITFQEA-------APSTSAKVVKLAA-----SEPRPAKPPEKEGF 184
                 .......|...|.|.:...:.       .|::|:.|....|     ...|.|..|.
  Rat    94 -----EDDDDDEVEGEEGGMVVEMDVEWRPGSRRPASSSAVSSAGARGRGLGSYRGAAYPS---- 149

  Fly   185 SLFKRKKKSVGSSTP-PSPSRG----HR------APSIIA-------------ASALQNRAKTNR 225
               .|:::......| |||:.|    ||      .|..:|             .:.|...:..||
  Rat   150 ---GRRRRLEDQGAPCPSPAGGGDPLHRHLPLDGQPPRVAWAERLVRGLRGLWGTRLMEESNANR 211

  Fly   226 ILYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFE 290
            ..|     :|..|.|...::.||||..::...:..:.::|:..|:.:||.  :..|:.:....|:
  Rat   212 EKY-----LRSVLRELVTYLFFLILLCILTYGMMSSNVYYYTRTLSQLFI--DTPVSKTEKTNFK 269

  Fly   291 KLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEA 355
            .|.::.|:|.:.:.:||..|:.
  Rat   270 TLSSMEDFWKFTEGSFLDGLYW------------------------------------------- 291

  Fly   356 PEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSF 420
                                          |.|              |.|:.:.|      |.||
  Rat   292 ------------------------------KAQ--------------SSNHTQAD------NRSF 306

  Fly   421 HHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKPM--HKGSP- 482
                   ..|||||||.|||||:|||..||.:..........||..||..:|||.|.  ..|:.
  Rat   307 -------IFYENLLLGVPRLRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAW 364

  Fly   483 -FRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNE 546
             :.:..||:.:..|.::|.|...||.::|...::.....:..|:...|||||:|...::|:::|.
  Rat   365 IYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQLAGLRRNFWLDRGTRAAFIDFSVYNA 429

  Fly   547 NTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEITEIR 611
            |.::|..::|:.|.|.||||:|....|.||:..:.|.....:....|.:...::||.:.||.|||
  Rat   430 NINLFCVVRLLVEFPATGGVVPSWQFQPVKLIRYVTAFDFFLAACEIIFCFFILYYVVEEILEIR 494

  Fly   612 KSGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTARAHSDVTYQSLDVLCFWNIIYVD 676
            ...:. ||.|..|.||..|::...:|::.||:.......|........::.:.:.:.:|.|.:.:
  Rat   495 IHRLN-YFRSFWNCLDVVIVVLSVVAMMINIYRMSNAEGLLQFLEDQNSFPNFEHVAYWQIQFNN 558

  Fly   677 MMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPD 741
            :.|::.||||||:||||:||:|:.|.:||:.||:|||.||::||.|:|||||||..|:|||:..|
  Rat   559 IAAVMVFLVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFTIMFFIIFLAYAQLAYLVFGTQVDD 623

  Fly   742 FRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGE 806
            |..|...|.|..|:||||..:..||:|||||||:||.|::..:||||||||||||.::|:.||.:
  Rat   624 FSTFQECIFTQFRIILGDINFAEIEEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSYSEVKSD 688

  Fly   807 ITQGRSHL-----------------------------------GSYIYRKLSGMLYWITHCGRK- 835
            :.|.::.:                                   |...:.:|...|....|...:
  Rat   689 LAQQKAEMELSDLIRKGCQKALVKLKLKRNTVDAISESLRQGGGKLNFDELRQDLKGKGHTDAEI 753

  Fly   836 ----------------RRHHPQ-----ASETEDKDAEHDVGAAHDETHEIRKNMTPAEQQYFKD- 878
                            .|.|.|     ..|.||.|.||........:....:::..:|::..:|
  Rat   754 EAIFTKYDQDGDQELTEREHQQMRDDLEREREDLDLEHSSLPRPMSSRSFPRSLDDSEEEDDEDS 818

  Fly   879 ---------IPQG----ENQDMVRLNNRVGLLEEILEKLINNMDDILKRVE 916
                     |..|    |.|.:||   ||..:|..:..:::.:|.::.::|
  Rat   819 GHSSRRRGSISSGVSYEEFQVLVR---RVDRMEHSIGSIVSKIDAVIVKLE 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	DUF5585	<29..272	CDD:465521	56/278 (20%)
		Polycystin_dom	404..578	CDD:466668	61/177 (34%)
		PKD_channel	579..803	CDD:462341	95/223 (43%)
Pkd2	NP_001178863.1	Polycystin_dom	267..461	CDD:466668	35/193 (18%)
		PKD_channel	462..685	CDD:462341	64/226 (28%)
		FRQ1	<732..772	CDD:444056	21/39 (54%)
		Fer4_24	832..866	CDD:436280	9/55 (16%)