DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and pkd2

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001002310.1	Gene:	pkd2 / 432387	ZFINID:	ZDB-GENE-040827-4	Length:	904	Species:	Danio rerio

Alignment Length:	972	Identity:	248/972 - (25%)
Similarity:	394/972 - (40%)	Gaps:	269/972 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 VGSTRSAP-----PPATDPTGPPP------------TAGKPVRDTGPSTSPRPSLR------DPG 104
            :.|:|..|     |.|:....|||            ..|..|.|..||:.|..|.|      :||
Zfish     1 MSSSRVRPQAPQSPAASASASPPPHEGIEMEKMHHEEVGLGVPDETPSSPPTSSSRQAWSRDNPG 65

  Fly   105 QSTSDKPSTSDKPSTSDKPSTSARTTVREPGPSSSPSRPVSTRESGRITFQEAAPSTSAKVVKLA 169
            ....:....:|.|                  |.|...|.|||..|          |:|..|
Zfish    66 FEPEEGMMEADWP------------------PESQGRRSVSTTSS----------SSSGGV---- 98

  Fly   170 ASEPRPAKPPEKEGFSLFKRKKKSVGSSTPPSPSRGHRA--------PSIIAASALQNRAKTNRI 226
                    |....|.|  .|..:.:   .|..|::.||:        ..::..:.|...:.:||.
Zfish    99 --------PGNFSGIS--ARINRGL---YPTPPAQEHRSCGKRILEKMRVLWDTRLLGESNSNRE 150

  Fly   227 LYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEK 291
            :|     ::..|.|...:|:||:...::...:..|.|:|:...|.:||.:..:  :......|:.
Zfish   151 MY-----LKTVLREMITYILFLLTLCIITYGMVSTNMYYYTKVMSQLFLDTPL--SSGEPTNFKS 208

  Fly   292 LITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAP 356
            |.|:.|:|.:.:..||..::.:|.:      |..|:|...|
Zfish   209 LSTMEDFWKFTEGPFLNGMYWELWY------NNKSLPENQS------------------------ 243

  Fly   357 EEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFH 421

Zfish   244 ----------------------------------------------------------------- 243

  Fly   422 HLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKPM--HKGSP-- 482
                 :..|||||||.|||||:|||.|||.|::........||..||...||:.|.  ..|:.
Zfish   244 -----LIYYENLLLGVPRLRQLRVRNESCSVHEDLRDEVYDCYNVYSPANEDKAPFGPKNGTAWR 303

  Fly   483 FRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNEN 547
            |:....|..:..|..::.|..|||..:|...::::...:.:||:..|||||:|...::|:::|.|
Zfish   304 FKDESSLGESSYWGQVSTYGGGGYYQDLSRTREKSANQLQELKNNLWLDRGTRAVFLDFSIYNGN 368

  Fly   548 TDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEITEIRK 612
            .::|..::|:.|.|.|||.:|....|||::..:.:.....:.:..:.:.:.|:||.:.|..|||.
Zfish   369 VNLFCIVRLLVEFPATGGAVPSWQFQTVRLLRYVSSWDYFVGMCEVSFCLFVLYYLVEEALEIRL 433

  Fly   613 SGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTARAH----SDVTYQSLDVLCFWNII 673
            ..:: ||.|:.|.||..|:.....|::.||   .:..:::.|.|    :..||.:.:.|....:.
Zfish   434 HRLR-YFKSLWNCLDVLIVALSVPAIIMNI---CRTSAVSHRLHFLLENHSTYPNFEPLARLQVH 494

  Fly   674 YVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTK 738
            :.::.||:.||.|:|:||||:||||:.|.:||:.||:|||.||::||.|||||||||..|:|||:
Zfish   495 FNNLAAIIVFLSWVKLFKFINFNKTMNQLSTTMSRCAKDLMGFAIMFFIVFLAYAQLAYLVFGTQ 559

  Fly   739 HPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTV 803
            ..||..|...|.|..|:|||||.::.||:|:.|||||||.|::..:|.||||||||||.:||:.|
Zfish   560 VNDFSTFQACIFTQFRIILGDFDFSEIEEADSVLGPIYFTTFVFFIFMILLNMFLAIINDTYSEV 624

  Fly   804 KGEITQGRSHL-----------------------------------GSYIYRKLSGMLYWITHCG 833
            |.::.|.||.:                                   |...:.:|...|....|..
Zfish   625 KADMAQQRSEMEITDLIKKSYNRAMVKLKLKKSSINDIPDSLQQAAGKLSFDELRQDLRGKGHSD 689

  Fly   834 RK-----------------RRHHPQ-----ASETEDKDAEHDVGAAHDETHEIRKNMTPAEQQYF 876
            .:                 ...|.|     ..|.||.|.||.............::...:|:...
Zfish   690 AEIEAIFAKYDLDGDQELTEHEHQQMRDDLEKEREDLDLEHSSLPRPASGRSFSRSQDDSEEDDD 754

  Fly   877 KD--------------IPQGENQDMVRLNNRVGLLEEILEKLINNMDDILKRVEKDYHNKKK 924
            :|              :...|.|.:||   ||..:|..:..:::.:|.::.::|.....|.|
Zfish   755 EDSGHSSRRRGSSSGGVSYEEFQVLVR---RVDRMEHSIGSIVSKIDAVIVKLEAMERAKMK 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	153/408 (38%)
pkd2	NP_001002310.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102		31/140 (22%)
		PKD_channel	204..624	CDD:285288	165/523 (32%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q13563	578..580		1/1 (100%)
		EFh	<671..715	CDD:324233	5/43 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..770		10/61 (16%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q13563	740..759		2/18 (11%)
		Pkinase	<781..>856	CDD:330832	8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586381
Domainoid	1	1.000	295	1.000	Domainoid score	I1460
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2331
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		otm26400
orthoMCL	1	0.900	-	-		OOG6_103020
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2725
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790