DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and brv1

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_649116.1	Gene:	brv1 / 40116	FlyBaseID:	FBgn0036874	Length:	728	Species:	Drosophila melanogaster

Alignment Length:	598	Identity:	115/598 - (19%)
Similarity:	230/598 - (38%)	Gaps:	149/598 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 DSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVR----------------KESCYVNDAFIR 458
            |..:......:.|.||      ..|||..||||:|..                .||..:....:.
  Fly   191 DGKNTSGGAPWIHAEG------TRLLGVVRLRQLRTESNRLGLSLPVFTERDFSESWTLPYERVP 249

  Fly   459 YFNTCYAAYS------SGAEDRKPM---HKGSPFRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDK 514
            |.:..:..|:      |.|.|...|   |.|..|.               :..:.||.|.|...:
  Fly   250 YTDKYWPIYTPWLPSVSVARDNLLMGINHVGHMFN---------------YPESKGYKVLLSDTR 299

  Fly   515 DRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKL-IAEIP---PTGGVIPQAHLQTV 575
            .:::|||:.|...:|||..:....::|:|:|.:.:.|....| :.:.|   |.|....::| ..|
  Fly   300 HKSLKIIDYLMKKNWLDANTTALFMDFSLYNADANTFTVCTLWVEKFPYQYPDGHTRIESH-TFV 363

  Fly   576 KMYSFFTDRSMLMTVIYIF-W------YIMVIYYTIYEITEIRKSGIKIYFCSMLNILDCAILLG 633
            :....||...|||..:::. |      :.:.::   |:..:::...:::    ...|:..::::|
  Fly   364 EQLREFTKFGMLMVFVFVVTWLQFTKAFFLKVW---YDPRQLKTLWVQV----DAMIVALSLVVG 421

  Fly   634 CYLALVYNIWHSFKVMSLTARAHSDVTYQSLDVLCFWNIIYV-DMMAILAF-LVWIKIFKFISFN 696
            ..:::..|:     |..:.......|....||......:.|: |::..||. ||.::::|.:.|:
  Fly   422 MIMSVRDNL-----VQKMIKSVEIAVVVDFLDFREPAQLAYLEDVVTGLAVALVTMRLWKVLQFS 481

  Fly   697 KTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQ 761
            .|...||.|:......|....::..|..:|.....:.:.|....:||:|...|:|:.....|
  Fly   482 ATFQLFTKTIAMAWDALLCTFVITVIFIIAIGIATVTINGNYTSNFRDFPKGIVTVTCFAFG--- 543

  Fly   762 YNLIEQANRVLGPIYF--------LTYILLVF---FILLNMFLAIIMETYNTVKGE--------I 807
                 ..|.|..|..|        |.|.::.|   ::|:|:.::::.:...:||.:        |
  Fly   544 -----YTNLVYPPDIFYGGEWLGILLYTIMGFVVKYMLINLIVSMMRDQMASVKADRDKKVRQRI 603

  Fly   808 TQGR------SHLGSYIYRKLSGMLYWITHC--GRKRRHHPQASETEDKDAEHDVGAAHDETHEI 864
            |..:      :|..:||.:        :.||  |.:|::...|...:.|          ..::|:
  Fly   604 TFWQFLRVEYAHFINYIVK--------VFHCQKGYQRKNRTVAQNIQRK----------LNSNEL 650

  Fly   865 RKNMTPAEQQYFKDI---PQGENQDMVRLNNRV-------GLLE---EILEKL-----------I 905
            ::..|.....|.:.|   |..::.:.::...|:       .:|.   |::|:|           :
  Fly   651 KRRKTKISSIYSETIYVMPIDKDLEQMKYRERIERTFTLAAILHTQMELMERLMFGDEEGNLPSL 715

  Fly   906 NNMDDILKRVEKD 918
            :..|:.:...|:|
  Fly   716 DQEDEQVPETEED 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	89/441 (20%)
brv1	NP_649116.1	PKD_channel	165..591	CDD:285288	89/441 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456383
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840