Protein Alignment Pkd2 and PKD1L3

DIOPT Version :10

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_853514.1
• Gene: PKD1L3 / 342372
• HGNCID: 21716
• Length: 1732
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 64/273 - (23%)
• Similarity: 128/273 - (46%)
• Gaps: 35/273 - (12%)

  Fly   585 SMLMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVM 649
            |::..|||   |::|.||...:..::::...: :|....||||.:|:|..::.|..::    |.:
Human  1466 SIISQVIY---YLLVCYYAFIQGCQLKQQKWR-FFTGKRNILDTSIILISFILLGLDM----KSI 1522

  Fly   650 SL----TARAHSDVT-----YQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTT 705
            ||    .||...|..     |:::.|    |.....::.....|..::::..:..:..|...:.|
Human  1523 SLHKKNMARYRDDQDRFISFYEAVKV----NSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRT 1583

  Fly   706 LKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIEQANR 770
            |.|...::.||.|:..|:...||....||||....|:|.|.:|.:|::.:::|......:...:.
Human  1584 LSRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDP 1648

  Fly   771 VLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEITQGRSHLGSYIYRKLSGML--YWITHCG 833
            |||....||.::|:..:::|:|::.|:..:...:..:.: .:.|...:.:|||.:|  .|
Human  1649 VLGTFLILTSVILMVLVVINLFVSAILMAFGKERKSLKK-EAALIDTLLQKLSNLLGISW----- 1707

  Fly   834 RKRRHHPQASETE 846
                  ||.:.:|
Human  1708 ------PQKTSSE 1714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	DUF5585	<29..272	CDD:465521
		Polycystin_dom	404..578	CDD:466668
		PKD_channel	579..803	CDD:462341	55/226 (24%)
PKD1L3	NP_853514.1	CLECT	33..138	CDD:153057
		GPS	633..672	CDD:470616
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	635..685
		PLAT_polycystin	743..859	CDD:238850
		PKD_channel	1467..1678	CDD:462341	54/222 (24%)
		Channel pore-region	1613..1651		9/37 (24%)