DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and Pkd2l1

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_852087.2	Gene:	Pkd2l1 / 329064	MGIID:	1352448	Length:	760	Species:	Mus musculus

Alignment Length:	890	Identity:	244/890 - (27%)
Similarity:	383/890 - (43%)	Gaps:	225/890 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 SPR-PSLRDPGQSTSDKPSTSDKPSTSDKPSTSARTTVREPGPSSSPSRPVSTRESGRITFQEAA 158
            ||: ..|:..|....|.|:.||.|                     ||:|.:      ||
Mouse     6 SPKNQELQTLGNRAWDNPAYSDPP---------------------SPNRTL------RI------ 37

  Fly   159 PSTSAKVVKLAASEPRPAKPPEKEGFSLFKRKKKSVGSSTPPSPSRGHRAPSIIAASALQNRAKT 223
                ..|..:|..|.:|.||..:    ..::.::::.||......|..|.   :..:.|......
Mouse    38 ----CTVSSVALPETQPKKPEVR----CQEKTQRTLVSSCCLHICRSIRG---LWGTTLTENTAE 91

  Fly   224 NRILYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVT-V 287
            ||.||     |:..|.|..|:|:||:...|:...:..:..:|:...|.:||.:     .||.: |
Mouse    92 NRELY-----VKTTLRELVVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLH-----TPSDSGV 146

  Fly   288 GFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVV 352
            .|:.:.::.|:||:
Mouse   147 SFQTISSMSDFWDF--------------------------------------------------- 160

  Fly   353 GEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQAN 417
                .:.|.:|.|.....||                                            |
Mouse   161 ----AQGPLLDSLYWTKWYN--------------------------------------------N 177

  Fly   418 MSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKPM--HKG 480
            .|..........|||||||.|||||:|||.:||.|::.|......||..||...||:.|.  ..|
Mouse   178 QSLGRGSHSFIYYENLLLGAPRLRQLRVRNDSCVVHEDFREDILNCYDVYSPDKEDQLPFGPQNG 242

  Fly   481 S--PFRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNL 543
            :  .:.:.::|..:..|..|..|..|||.::|...:..:.:.:..|::..|||||:|:..::|::
Mouse   243 TAWTYHSQNELGGSSHWGRLTSYSGGGYYLDLPGSRQASAEALQGLQEGLWLDRGTRVVFIDFSV 307

  Fly   544 FNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEIT 608
            :|.|.::|..::|:.|.|.|||.||...::|||:..:..:....:....:.:.:.:.||.:.||.
Mouse   308 YNANINLFCILRLVVEFPATGGTIPSWQIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEIL 372

  Fly   609 EIRKSGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTAR-AHSDVTYQSLDVLCFWNI 672
            ||....:: |..|:.||||..::|...:|:.::|:.:.:|..|..: .....||...:.|.||..
Mouse   373 EIHLHRLR-YLSSVWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQT 436

  Fly   673 IYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGT 737
            .|.:|.|:..|..||||||:||||||:.|.::||.||:||:.||::||.|||.||||||.|||||
Mouse   437 QYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGT 501

  Fly   738 KHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNT 802
            :..:|..|:..|.|..|:|||||.||.|:.|||:|||:||:||:..|||:|||||||||.:||:.
Mouse   502 QVENFSTFVKCIFTQFRIILGDFDYNAIDNANRILGPVYFVTYVFFVFFVLLNMFLAIINDTYSE 566

  Fly   803 VKGEITQGRSHL-------GSY----------------IYRKLSG---------MLYWITHCGRK 835
            ||.|:...:..|       .||                :.:.|.|         ....:...|.:
Mouse   567 VKEELAGQKDQLQLSDFLKQSYNKTLLRLRLRKERVSDVQKVLKGGEPEIQFEDFTSTLRELGHE 631

  Fly   836 RRHHPQASETEDKDAEHDVGAAHDETHEIRKNM--------------------TP-----AEQQY 875
            ......|....|:|.:|.:.  .:|..::|:.:                    :|     ||...
Mouse   632 EHEITAAFTRFDQDGDHILD--EEEQEQMRQGLEEERVTLNAEIENLGRSVGHSPPGELGAEAAR 694

  Fly   876 FKDIPQGENQDMVRLNNRVGLLEEILEKLINNMDDI---LKRVEK 917
            .:....||..||  |..||..|:.:||.:::.:|.:   ||.:|:
Mouse   695 GQSWVSGEEFDM--LTRRVLQLQCVLEGVVSQIDAVGSKLKMLER 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	159/405 (39%)
Pkd2l1	NP_852087.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		9/44 (20%)
		PKD_channel	146..567	CDD:285288	169/520 (33%)
		EF-hand_8	616..654	CDD:290545	5/39 (13%)
		Required for homooligomerization. /evidence=ECO:0000250	701..760		14/39 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	313	1.000	Domainoid score	I1300
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2221
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		otm42741
orthoMCL	1	0.900	-	-		OOG6_103020
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2725
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860