DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and Pkdrej

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001128338.1	Gene:	Pkdrej / 300124	RGDID:	1306587	Length:	2121	Species:	Rattus norvegicus

Alignment Length:	742	Identity:	149/742 - (20%)
Similarity:	262/742 - (35%)	Gaps:	224/742 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 TPPSPSRGHRAPSIIAASALQNRAKTNRI-LYTTDEEVREALVEFSVFI----IFLILTSLVVLS 257
            ||....:.|...:.|.:.::......::| ::.....:|:....|..::    |||.|..|::..
  Rat  1534 TPEETEQLHEDMAYIRSLSIYQPITEDKIQIFRRKNRIRKRSFLFLSYLVTHFIFLTLLLLLIFP 1598

  Fly   258 VRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQA 322
            :||...||:|..::..|:   |.:|..|.:|        |.:.:|...||..||.|
  Rat  1599 LRHNDSFYYNQFVRHRFS---MDLATVVKLG--------DIYAWLNGVFLPLLHND--------- 1643

  Fly   323 NLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKR 387
                                   :||
  Rat  1644 -----------------------KSP--------------------------------------- 1646

  Fly   388 QSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVR--KESC 450
                             .:|.|.|..|                    ||.|.:||:|.:  .::|
  Rat  1647 -----------------TFLPDSSSKI--------------------LGLPLMRQVRAKPSNKTC 1674

  Fly   451 YVNDAF----IRYFNTCYAAYSSGAEDRKPMH---------KGSPFRTMHDLDSTP---IWT--- 496
            .:...|    |.....|:..|....||.:  |         |.|..:|.:.....|   .|.
  Rat  1675 LLAKKFAQSRIAGELHCHPQYGIDPEDTR--HYPGVWNKAGKRSIDKTSNGFTYKPPGRKWVYYS 1737

  Fly   497 --VLAFYRTGGYTVNL--DYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLI 557
              ||..|.:|||....  :.....:...:.:|:..:|||..:...:||....|.:|.:..||.::
  Rat  1738 YGVLNTYGSGGYEFYFFPEQQMFNSTLRLKELEGKNWLDELTWAVIVELTTLNPDTSLMCSISVV 1802

  Fly   558 AEIPPTGGVIPQAHLQTVKMYSF----FTDRSMLMTVIYIFWYIMVIYYTI---YEITEIRKSGI 615
            .|:.|.|.|     ..::.:|||    |..||.....:|:...|....|.:   |.|.:.|.|
  Rat  1803 FEVSPLGVV-----NSSLSVYSFPLADFNSRSSAEIYLYVAILIFFCAYVVDEGYIIMQERAS-- 1860

  Fly   616 KIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTARAHSDVTYQSLD---VLCFWNIIYVD- 676
              |..||.|:|:.:  |.|..||:..::  |:...|..:.   |...:.|   .:.|..:..||
  Rat  1861 --YIRSMYNLLNFS--LKCMFALLIVLF--FQKHLLATKL---VRLYNTDPEAFIPFHAVSRVDH 1916

  Fly   677 -MMAILAFLVWIKIFKFIS-----FNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLF 735
             |..|||||:::.|.|.:.     :|..|.|  .|::.....:...:|:..|....|...|.|:|
  Rat  1917 FMRIILAFLLFLTILKTLRYSRFFYNVRLAQ--KTIQAAFPGICHTALVVSIYSFMYVAFGYLVF 1979

  Fly   736 GTKHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETY 800
            |....::.|.|.:..|:....:..|| |.....|::||.::..:::|::..|.:|:|..:|:..|
  Rat  1980 GQHEWNYSNMIHATQTIFSYCVSAFQ-NTEFSGNKILGVLFLSSFMLVMICIFINLFQVVILSAY 2043

  Fly   801 NTVKGEITQ---GRSHLGSYIYRKLSGMLYWITHCGRKRRHHPQASETEDKDAEHDVGAAHDETH 862
            :.:|..:.:   ..:...:|:...|.....::|            |..:|||
  Rat  2044 DEMKQPVYEEPSDEAEAVTYLCDSLKSGFDFLT------------SGPQDKD------------- 2083

  Fly   863 EIRKNMTPAEQQYFKDIPQGENQDMVR 889
                     :..:|:|:..|:.:...|
  Rat  2084 ---------QSDFFEDMLYGQPEKNTR 2101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	106/442 (24%)
Pkdrej	NP_001128338.1	REJ	132..598	CDD:280229
		PLAT_polycystin	1111..1226	CDD:238850
		PKD_channel	1616..2046	CDD:285288	119/569 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345343
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740